COMMON

• sleeping problems
• headache, dizziness
• nausea, vomiting, diarrhea

UNCOMMON

• candidiasis (a fungal infection)
• anxiety, confusion, nervousness, sleepiness, trembling, and spinning sensation
• shortness of breath
• altered taste, loss of appetite, stomach upset, indigestion, stomach ache, flatulence, constipation
• itching, skin rash, red itchy welts, hyperhidrosis (increased sweating)
• joint and muscle pain
• general weakness

RARE

• signs of low blood sugar such as shakiness, sweating, headache, hunger, and/or nausea
• depression, mental problems, agitation, abnormal dreams/nightmares
• tingling sensation in hands and feet
• hearing impairment (tinnitus), blurred vision
• fever, racing heartbeat, low blood pressure, muscle weakness
• interstitial nephritis (allergic kidney reaction associated with altered kidney function and occasional kidney failure)
• sharply demarcated, erythematous patches with/without blisters

Stop taking LOXOF 500MG TABLET and consult your doctor immediately in case you experience:

• signs of allergic reaction such as rash, swallowing/breathing problems, swelling of lips/face/throat/tongue
• fits
• signs of DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) such as widespread rash, high fever, liver enzyme elevations, white blood cell abnormalities, and/or enlarged lymph nodes
• signs of SIADH (syndrome associated with impaired water excretion and low levels of sodium) such as nausea, vomiting, cramps, and/or irritability
• bruising and bleeding due to thrombocytopenia (a condition that occurs due to a lowering of blood platelet count)
• neutropenia (low white blood cell count)
• signs of hypersensitivity reaction (exaggerated immune response) such as skin rash, red itchy welts, fever, shortness of breath
• change in psychotic reactions such as hallucinations, paranoia
• serious skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis (associated with signs such as reddish macules/circular patches with central blisters on the trunk, skin peeling, ulcers of the mouth/throat/nose/genitals/eyes preceded by fever and flu-like symptoms)
• signs of liver problems such as loss of appetite, skin and eyes becoming yellow in colour, dark-coloured urine, itching, and/or abdomen
• signs of neuropathy (nerve damage) such as burning, tingling, pain, and/or numbness
• signs of severe bowel problems such as watery diarrhea, stomach cramps, fever
• pain and inflammation in tendons/ligaments
• signs of agranulocytosis (a condition that occurs due to the lowering of white blood cells) such as fever, sore throat, and/or a general feeling of being unwell
• loss of circulation due to anaphylactic shock (severe allergic reaction)
• temporary loss of consciousness/posture (syncope)
• temporary loss of vision
• signs of prolongation of QT interval such as abnormal fast heart rhythm, cardiac arrest, alteration of the heart rhythm
• signs of aortic aneurysm (a large bulge in the aortic artery) and dissection (a tear in the inner layer of the aortic artery), such as sudden, severe pain in your abdomen, chest, or back
• rapid onset of shortness of breath (especially when you lie down flat in your bed), swelling of ankles, feet, and abdomen, and/or new onset of heart palpitations
• inflammation of pancreas
• inflammation of liver
• pain/inflammation of tendon in ankle, wrist, elbow, shoulder, and/or knee
• rhabdomyolysis (condition marked by muscle rupture and muscle destruction)
• suicidal thoughts/actions
• porphyria (a very rare metabolic disease)
• impaired eyesight or other eye disturbances

OTHERS

LOXOF 500MG TABLET is not recommended for use if you:

• have/ever had epilepsy (seizure)
• have/ever had tendinitis (inflammation/irritation of tendon) after management with quinolone antibiotics

Before taking LOXOF 500MG TABLET, inform your doctor if you:

• have had damage to your brain due to a stroke or other brain injury
• are suffering from glucose-6-phosphate dehydrogenase deficiency (a genetic disorder of red blood cells)
• have ever had mental health problems
• are diabetic
• suffer from myasthenia gravis (long-term neuromuscular junction disease)
• have a history of aneurysm (bulge or enlargement of a large blood vessel)
• suffer from connective tissue disorders such as Marfan syndrome, vascular Ehlers-Danlos syndrome, Turner syndrome, and Sjogren’s syndrome
• have a salt imbalance in the blood
• suffer from vascular disorders such as Takayasu arteritis, giant cell arteritis, Behçet´s disease, high blood pressure, or known atherosclerosis, rheumatoid arthritis
• have ever developed a severe skin rash/peeling, blistering, and/or mouth sores after taking the medicine
• have received an organ transplant

STORAGE

• Keep LOXOF 500MG TABLET out of reach of children
• Store LOXOF 500MG TABLET at room temperature