INTRODUCTION

LASILACTONE is a combination of Spironolactone and Frusemide which belongs to the group of medicines called Diuretics. It helps to reduce fluid build-up (edema) in the body. Edema is a type of swelling or puffiness of body parts caused due to excessive accumulation of fluid (water) in the body. These extra fluids can cause swollen ankles, shortness of breath and can make you feel more tired than usual. It can also put extra strain on your heart, blood vessels, lungs, kidneys, or liver.

Spironolactone is a potassium sparing diuretic and frusemide is a loop diuretic. They act by removing the excess water and certain electrolytes (sodium and chloride) from the body in the form of urine. Unlike other diuretics, LASILACTONE retains potassium in the body which prevents the risk of developing hypokalaemia (low blood potassium levels).

Before taking LASILACTONE inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you are severely dehydrated or have diabetes, gout, prostate problems, or low blood pressure which makes you feel dizzy while standing up or changing position.

During management with LASILACTONE, avoid consuming potassium rich diet or potassium supplements, as it may further increase the levels of potassium in your body.

LASILACTONE is not recommended for use in patients with severe low sodium levels in their blood. It is also not suitable for use in pregnant or breastfeeding women due to increased risk of side effects.

LASILACTONE may alters the levels of electrolytes in your body and may make you feel dizzy or tired very easily. To avoid this, your doctor would closely monitor your serum electrolyte levels and increase or decrease the dose of LASILACTONE accordingly.

The most common side effects of [GBKEYWORD] are headache, dizziness, nausea, vomiting, tiredness, muscle weakness, increased urination, or impotence. Consult your doctor if any of the side effect bothers you.

USES OF LASILACTONE

• Manages edema (fluid retention)

HOW LASILACTONE WORKS

LASILACTONE acts by removing the excess water and certain electrolytes (sodium and chloride) from the body in the form of urine while simultaneously maintaining the levels of potassium in the body.

DIRECTIONS FOR USE

Take LASILACTONE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. It is taken preferably with meals. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Avoid taking LASILACTONE at night as it could affect your sleep. Do not stop taking LASILACTONE unless your doctor tells you to stop.

SIDE EFFECTS OF LASILACTONE

HOW TO MANAGE SIDE EFFECTS

Nausea and Vomiting:

Take LASILACTONE with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your nausea worsens.

Headache:  

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely if you feel dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interaction:

Before taking LASILACTONE, inform your doctor if you are taking any of the following medicines such as:

• medicines that can change the amount of potassium in your blood such as potassium supplements (Ex. potassium chloride) or potassium sparing diuretics (Ex. triamterene and amiloride)
• medicines used to control elevated blood pressure (such as losartan, candesartan, irbesartan, ramipril, enalapril, perindopril)
• medicines used for relaxing muscles during surgery (Ex. vecuronium and rocuronium)
• medicines used to manage diabetes (Ex. metformin, glimepiride)
• theophylline (a medicine used for asthma)
• phenytoin, carbamazepine (medicines used to manage fits or epilepsy)
• lithium, risperidone (medicines used for mental illnesses)
• medicines used to manage certain forms of cancer (Ex. cisplatin, aminoglutethimide, abiraterone)
• digoxin (a medicine used to manage abnormal heart rate)
• non-steroidal anti-inflammatory drugs (used for pain relief) such as indomethacin, aspirin, ibuprofen, or ketoprofen
• ciclosporin (a medicine used to prevent graft rejection)
• methotrexate (a medicine used for skin cancer, arthritis, or bowel diseases)
• carbenoxolone (used to manage ulcers of the food-pipe)
• corticosteroids (used to manage inflammation) Ex. prednisolone
• probenecid (a medicine used to manage gout)
• cholestyramine (a medicine used to control blood cholesterol levels
• medicines used to manage bacterial infections (Ex. trimethoprim, sulfamethoxazole, ceftriaxone, cefazolin, gentamycin, streptomycin, amikacin, neomycin, netilmicin, tobramycin, vancomycin)
• bendroflumethiazide (another diuretic used to manage edema)
• medicines used as injections before X-ray examinations (Ex. iodine)
• medicines used to manage asthma (such as salbutamol, terbutaline, salmeterol, formoterol or bambuterol)
• reboxetine (a medicine used to manage depression)
• amphotericin (a medicine used to manage fungal infections)
• medicines used to manage constipation such as laxatives (Ex. bisacodyl, Senna)
• liquorice (a medicine used in cough preparations)

Overdosage:

If you or anyone else accidentally took more LASILACTONE, consult your doctor immediately. Symptoms of overdosage might include increased thirst, dryness of mouth, muscle pain or cramps, nausea or vomiting, weak or uneven heartbeat, feeling dizzy, weak or sleepy.

SYNOPSIS

MORE INFORMATION

• Keep LASILACTONE out of reach of children
• Store LASILACTONE at room temperature