INTRODUCTION ABOUT IVABRAD 5MG TABLET

Ivabrad 5 Tablet is used to manage symptomatic stable angina pectoris (chest pain) in adult patients who are intolerant/incapable to take heart medicines (such as beta blockers) and whose heart rate is over/equal to 70 beats per minute.

It is also used to manage chronic heart failure in adult patients whose heart rate is over/equal to 75 beats per minute, which are used as a combination therapy with beta-blockers, or in adult patients who are contraindicated to use beta-blockers.

It contains a medicine called Ivabradine, which belongs to the group of medicines called Hyperpolarization-activated cyclic nucleotide-gated channel blockers. It works by slowing down your heart rate, which reduces the heart’s need for oxygen. This helps improve blood flow and reduces chest pain or strain on the heart.

Ivabrad is not recommended for use in patients allergic to ivabradine. It is also not recommended for use in patients suffering from very low blood pressure, heart problems (such as unstable angina, cardiogenic shock), severe kidney disease, and/or severe liver disease.

Before taking Ivabrad, inform your doctor if you have mild to moderate low blood pressure, chronic eye retinal disease, recent stroke (cerebral attack), heart rhythm disorders (such as irregular heartbeat, palpitation, increase in chest pain), and/or moderate liver disease.

Ivabrad is generally not recommended for use in pregnant and breastfeeding women, in children, or in adolescents (aged below 18 years). Elderly patients (aged above 65 years) should use this medicine with caution after consulting their doctor.

The most common side effects of taking Ivabrad are brief moments of increased brightness (due to sudden changes in light intensity), slow heart rate, uncontrolled blood pressure, headache, dizziness, and/or blurred vision. Consult your doctor if any of these symptoms worsen.

USES OF IVABRAD 5MG TABLET

• Symptomatic stable angina pectoris (chest pain) in adult patients (with a heart rate above or equal to 70 beats per minute)
• Chronic heart failure in adult patients (with a heart rate above or equal to 75 beats per minute)

HOW IVABRAD 5MG TABLET WORKS

Ivabrad Tablet works by reducing the heart rate, which leads to a low oxygen requirement of the heart, resulting in improved blood supply throughout the body (with each heartbeat), thus providing relief from angina pectoris and managing the occurrence of chronic heart failure in affected individuals.

DIRECTIONS FOR USE

• Take Ivabrad Tablet as advised by your physician.
• For Tablet: Swallow the medicines with a glass of water. Do not crush or chew the medicine.
• For Orally Disintegrating Tablet: Place Ivabrad Tablet inside your mouth and allow it to dissolve completely.
• Do not swallow or chew the medicine.
• Your physician will decide the correct dose and duration for you depending on your age, body weight, and disease condition.

SIDE EFFECTS OF IVABRAD 5MG TABLET

COMMON

• brief moments of increased brightness (due to sudden changes in light intensity)
• slow heart rate
• signs of atrial fibrillation (irregular rapid contraction of the heart) such as chest pain, pounding heartbeat, and tiredness
• uncontrolled blood pressure
• headache, dizziness, blurred vision

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-drug interactions:

Before taking Ivabrad 5 Tablet, inform your doctor if you are taking any of the following medicine:

• medicines used to manage fungal infections (Ex. fluconazole, ketoconazole, itraconazole)
• rifampicin (medicine used to manage tuberculosis)
• barbiturates (medicines used for difficulty sleeping or epilepsy)
• phenytoin (used for epilepsy)
• hypericum perforatum/St. John’s Wort (herbal medicines used for depression)
• medicines used to manage heart rhythm disorders (Ex. quinidine, disopyramide, sotalol, ibutilide, amiodarone)
• bepridil (medicine used to manage angina pectoris)
• medicines to manage anxiety, schizophrenia, or other psychoses (Ex. pimozide, ziprasidone, sertindole)
• medicines used to manage malaria (Ex. mefloquine, halofantrine)
• intravenous erythromycin (medicine used to manage bacterial infections in different parts of the body)
• pentamidine (medicine used in the management of pneumocystis pneumonia, leishmaniasis, and trypanosomiasis)
• cisapride (used for acid reflux)
• diuretics (medicines used to manage oedema, high blood pressure) Ex. furosemide, hydrochlorothiazide, indapamide
• clarithromycin, josamycin, telithromycin, and erythromycin (medicines used for bacterial infections)
• nelfinavir, ritonavir (medicines used to manage HIV infections)
• nefazodone (medicine used to manage depression)
• diltiazem, verapamil (medicines used to manage high blood pressure/angina pectoris)

B. Drug-food interaction:

Avoid drinking grapefruit juice while taking Ivabrad Tablet, as it may alter the effect of the medicine.

Overdosage:

If you or anyone else accidentally takes too much of Ivabrad Tablet, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are breathlessness and tiredness.

SYNOPSIS