INTRODUCTION ABOUT GLIMESTAR PM1 TABLET

GLIMESTAR PM1 TABLET is used to manage type II diabetes mellitus when diet, exercise and management with single agent does not result in adequate sugar control. It is a combination of Glimepiride, Metformin and Pioglitazone which belongs to the group of medicines called Antidiabetic agents.

Before taking GLIMESTAR PM1 TABLET, inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any eye problems, hormonal imbalance, alcoholism, or if you are malnourished, starved, on an irregular diet as a precaution. It is strictly not recommended for use in patients with type I diabetes mellitus, bladder cancer, severe heart failure or lactic acidosis.

Along with the management, follow the diet and lifestyle changes advised by your doctor to achieve better results. Avoid smoking and consumption of alcohol while taking the medicine as it may aggravate the existing condition. The most common side effects are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness and weight gain. Consult your doctor if any of these side effect worsens.

USES OF GLIMESTAR PM1 TABLET

• Used to manage type II diabetes mellitus

HOW GLIMESTAR PM1 TABLET WORKS

GLIMESTAR PM1 TABLET stimulates the pancreas to secrete more insulin (a hormone involved in glucose metabolism). It also makes our body more sensitive to insulin which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels. Additionally, it can also reduce the glucose produced by the liver and reduces its absorption in the body.

DIRECTIONS FOR USE

• Take GLIMESTAR PM1 TABLET preferably after meals or as advised by your physician
• Swallow the medicine with a glass of water. Do not crush or chew the medicine
• Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
• Do not stop taking GLIMESTAR PM1 TABLET unless your doctor advice you to stop

SIDE EFFECTS OF GLIMESTAR PM1 TABLET

Common side effects of GLIMESTAR PM1 TABLET:

• hypoglycemia (low blood sugar levels)
• diarrhea, stomach pain, loss of appetite, flatulence
• changes in taste, metallic taste
• joint pain, back pain, muscle pain

Stop taking GLIMESTAR PM1 TABLET and contact your doctor immediately if you experience any of the following side effects:

• signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)
• symptoms of heart failure (such as unusual shortness of breath or trouble in breathing, rapid increase in weight or localised swelling (oedema), especially in the ankles or legs, unusual tiredness)
• signs and symptoms of bladder cancer (blood in your urine, pain while urinating or urgent need to pee)
• increased risk of fractures (especially in the bones of hand, upper arm, or foot in women)
• blurred vision due to swelling at the back of the eye or worsening of existing blurred vision
• serious allergic reaction (hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
• signs of liver problems (nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin or the whites of the eyes)

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interactions:

Before taking GLIMESTAR PM1 TABLET, inform your doctor if you are taking any of the following medicines:

• Antidiabetics (Ex. teneligliptin, rosiglitazone, insulin, gliclazide)
• Non-steroidal anti-inflammatory agents (Ex. aspirin, ibuprofen, celecoxib, phenylbutazone, azopropazone, oxyphenbutazone)
• Antibiotics (Ex. amikacin, nitrofurantoin, sulfamethoxazole, tetracyclines, chloramphenicol, ciprofloxacin, clarithromycin, Trimethoprim)
• Antifungals (Ex. fluconazole, miconazole, isuvaconazole)
• Anticoagulants (Ex. warfarin)
• Hormone replacement therapy (Ex. testosterone)
• Antidepressants (Ex. moclobemide, isocarboxazid, phenelzine, tranylcypromine, fluoxetine, chlorpromazine, prochlorperazine, lithium)
• Anti-lipidemic agents (Ex. fenofibrate, nicotinic acid, colesevelam)
• Antihypertensives (Ex. enalapril, lisinopril, ramipril, atenolol, propranolol, telmisartan, olmesartan, clonidine, guanethidine and reserpine)
• Anti-arrhythmic agent (Ex. Disopyramide)
• Anti-gout agents (Ex. allopurinol, probenecid, sulfinpyrazone)
• Anti-cancer agents (Ex. cyclophosphamide, ifosfamide, trofosfamide, vandetanib, crizotinib and olaparib)
• Hemorrheologic agents (Ex. Pentoxifylline)
• Enzyme inhibitor (Ex. tritoqualine)
• Alpha blockers (Ex. prazosin, doxazosin)
• Hormonal replacement therapy (Ex. estradiol)
• Thiazide diuretics (Ex. hydrochlorothiazide)
• Hormones (Ex. Levothyroxine)
• Corticosteroids (Ex. prednisolone, betamethasone)
• Bronchodilators (Ex. salbutamol, terbutaline)
• Alpha- and beta-adrenergic agonists (Ex. Adrenaline)
• Laxatives (Ex. lactulose, liquid paraffin)
• Anticonvulsants (Ex. phenytoin, Fenfluramine)
• Barbiturates (Ex. phenobarbital)
• Carbonic anhydrase inhibitor (Ex. acetazolamide)
• H2 blockers (Ex. Cimetidine)
• Anti-TB agents (Ex. Rifampicin)
• HIV integrase inhibitors (Ex. Dolutegravir)
• Anti-anginal (Ex. Ranolazine)

Overdosage:

If you or anyone else accidentally took more GLIMESTAR PM1 TABLET, you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat and confusion). To manage this, consume any sugary food immediately. If the symptom did not improve or worsens contact your doctor immediately. Other symptoms of overdosage might include vomiting, stomach pain with muscle cramps, feeling generally unwell with severe tiredness and difficulty in breathing.

SYNOPSIS