INTRODUCTION ABOUT DOLOWIN MR TABLET

DOLOWIN MR TABLET is a combination of Aceclofenac, Chlorzoxazone and Paracetamol which belongs to the group of medicines called Analgesics and Muscle relaxants respectively. It is used to manage muscular pains and spasms. It can also be used to provide relief from joint pain (Ex. osteoarthritis, rheumatoid arthritis) and back pain (Ex. ankylosing spondylitis).

Take DOLOWIN MR TABLET preferably with meals to avoid gut irritation. Avoid consumption of alcohol as it could aggravate the risk of stomach problems. Do not take DOLOWIN MR TABLET if you have any ulcers, bleeding or perforations in the gut.

Before taking DOLOWIN MR TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have diabetes, hypertension, high blood cholesterol, any inflammation in the bowel or intestines, blood clots, bleeding problems or a previous history of stomach ulcers as a precaution.

DOLOWIN MR TABLET is not recommended for use in patients with liver failure or stroke. It is also not suitable for use in pregnant or breastfeeding women. The most common side effects of taking DOLOWIN MR TABLET are nausea, vomiting, indigestion, heartburn and stomach pain. Consult your doctor if any of these side effect worsens.

USES OF DOLOWIN MR TABLET

It is used to manage:

• Muscle pain and spasms
• Joint pain and back pain

HOW DOLOWIN MR TABLET WORKS

DOLOWIN MR TABLET contains three medicines namely Chlorzoxazone, Aceclofenac and paracetamol. Chlorzoxazone is a muscle relaxant. It acts by increasing the effects of certain chemical messengers (such as GABA) in the brain and in spinal cord that induces muscle relaxation. As a result, it manages muscle twitching, relieves pain caused due to muscle spasms and improves muscle movement.

Aceclofenac and paracetamol are analgesic agents. They provide pain relief by blocking the release of certain chemicals (such as prostaglandins) in the body that causes pain, inflammation and swelling. Collectively, these action helps in reducing muscle spasms, joint pain and inflammation.

DIRECTIONS FOR USE

Take DOLOWIN MR TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. It is preferably taken with meals to avoid gastric irritation.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF DOLOWIN MR TABLET

HOW TO MANAGE SIDE EFFECTS

Nausea and Vomiting:

Take DOLOWIN MR TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Constipation:

Eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Exercise more regularly. Consult your doctor if the symptom did not improve.

Mouth ulcers:

Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.

Diarrhea:

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to manage diarrhea and consult your doctor if the symptom gets worse.

Skin rash:

Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interactions:

Before taking DOLOWIN MR TABLET, inform your doctor if you are taking any of the following medicines such as:

• other medicines used to manage pain (Ex. aspirin, ibuprofen, naproxen, celecoxib, etoricoxib)
• medicines used to manage increased blood pressure (Ex. enalapril, lisinopril, losartan, candesartan, methyldopa, clonidine, propranolol)
• diuretics (used to reduce edema and blood pressure) Ex. furosemide, hydrochlorothiazide
• cardiac glycosides (used to correct heart rhythm (Ex. digoxin)
• medicines used to suppress immune system after organ transplantation (Ex. ciclosporin or tacrolimus)
• medicines used to stop blood clotting (Ex. warfarin, heparin, clopidogrel)
• cholestyramine (a medicine used to control blood cholesterol levels)
• corticosteroids (used to manage pain and inflammation) Ex. hydrocortisone, prednisolone
• medicines used to manage nausea and vomiting (Ex. domperidone, metoclopramide)
• chloramphenicol (a medicine used to manage bacterial infections)
• medicines used to manage infections (Ex. ciprofloxacin, ofloxacin, levofloxacin, moxifloxacin)
• medicines used to manage depression (Ex. citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine and sertraline)
• medicines used to manage cancer and autoimmune disorders such as arthritis and skin conditions (Ex. methotrexate)
• medicines used to manage HIV infection (Ex. zidovudine)
• medicines used to manage diabetes (Ex. glibenclamide, gliclazide, tolbutamide)

Overdosage:

If you or anyone else accidentally took more DOLOWIN MR TABLET, visit the nearby hospital or consult your doctor immediately.

SYNOPSIS

MORE INFORMATION

• Keep DOLOWIN MR TABLET out of reach of children
• Store DOLOWIN MR TABLET below 25°C