INTRODUCTION ABOUT CARDACE METO 5MG TABLET

CARDACE METO 5MG TABLET is a combination of Metoprolol and Ramipril which belongs to the group of medicines called Antihypertensive agents. It is used to manage hypertension (high blood pressure) and angina (chest pain). It can also be used to manage heart failure and reduces the chances of hospitalization among the heart patients.

It also protects the function of kidneys particularly in patients who have both hypertension and type II diabetes mellitus.

Before taking CARDACE METO 5MG TABLET inform your doctor if you have any liver, kidney or heart problems apart from hypertension, angina and heart failure. You must also inform your doctor if you have asthma, COPD, diabetes, severe dehydration due to any recent sickness (such as vomiting or diarrhea), psoriasis or muscle problems before taking CARDACE METO 5MG TABLET as a precaution.

CARDACE METO 5MG TABLET is not recommended for use in patients with severe hypotension (low blood pressure). It is also not suitable for use in women who are pregnant or breastfeeding due to increased risk of side effects.

The most common side effects of taking CARDACE METO 5MG TABLET are dizziness, swelling of ankles or other body parts, headache, sleepiness, tiredness, indigestion, constipation and muscle cramps. Contact your doctor if any of these side effects trouble you.

USES OF CARDACE METO 5MG TABLET

It is used to:

• Manage hypertension and angina
• Manage and manage heart failure
• Protect kidney functions in patients with hypertension and diabetes

HOW CARDACE METO 5MG TABLET WORKS

CARDACE METO 5MG TABLET contains two medicines namely metoprolol and ramipril. Metoprolol is a beta-blocker. It blocks the effects of certain chemicals in the body (such as adrenaline) that increases heart rate and blood pressure.

Ramipril is an ACE inhibitor. It blocks the effects of certain enzymes in the body (such as angiotensin converting enzyme (ACE)) that causes narrowing of blood vessels and increase in blood pressure.

Collectively, blocking the actions of adrenaline and ACE reduces the strain on the heart and relaxes the blood vessels supplying the heart and the kidneys, which improves blood flow and oxygen supply to them and reduces blood pressure and kidney damage.

DIRECTIONS FOR USE

Take CARDACE METO 5MG TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Continue to take CARDACE METO 5MG TABLET for the stipulated duration instructed by your doctor to achieve better results.

SIDE EFFECTS OF CARDACE METO 5MG TABLET

HOW TO MANAGE SIDE EFFECTS

Nausea:

Take CARDACE METO 5MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Constipation:

Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking CARDACE METO 5MG TABLET inform your doctor, if you are taking any of the following medicines such as:

• medicines used to manage stomach ulcers (such as cimetidine)
• medicines used to manage high blood pressure (such as hydralazine, clonidine, prazosin, aliskiren, sacubitril/valsartan, verapamil or diltiazem)
• medicines used to manage irregular heart rhythm (such as amiodarone, procainamide, digoxin and propafenone)
• medicines used to manage depression (such as moclobemide, paroxetine, fluoxetine isocarboxazid, phenelzine, selegiline, tranylcypromine, lithium)
• medicines used to manage epilepsy (such as phenobarbital, phenytoin)
• anaesthetics (used to causes numbness of body parts or loss of consciousness) such as lidocaine, cyclopropane or trichloroethylene
• medicines used to manage some cancers (such as aldesleukin)
• medicines used to manage erectile dysfunction (such as alprostadil)
• medicines used to reduce anxiety and to induce sleep (such as temazepam, nitrazepam, diazepam)
• non-steroidal anti-inflammatory drugs (used for pain relief) Ex. indomethacin, ibuprofen, aspirin
• rifampicin (a medicine used to manage tuberculosis infection)
• terbinafine (a medicine used to manage fungal infections)
• contraceptive pills (birth control pills) such as ethinyl Estradiol
• hormone replacement therapy (used to manage menstrual problems) such as estrogens
• corticosteroids (used to manage pain and inflammation) such as hydrocortisone, prednisolone
• anti-diabetic medicines and insulin (used to lower the blood glucose level) Ex. vildagliptin, metformin
• timolol eye drops (used to manage glaucoma)
• sympathomimetic drugs (used to manage low blood pressure, asthma, allergies or heart failure) such as ephedrine, noradrenaline or adrenaline
• moxisylyte (a medicine used in Raynaud’s syndrome)
• medicines used to manage asthma (such as aminophylline or theophylline)
• medicines to manage migraines (such as ergotamine)
• medicines used to manage rheumatoid arthritis (such as hydroxychloroquine)
• diphenydramine (an allergic medicine)
• medicines used to manage graft rejection (Ex. ciclosporin, sirolimus, everolimus)
• medicines that supplement potassium to the body (Ex. spironolactone, triamterene or amiloride)
• trimethoprim, co-trimoxazole (used to manage bacterial infections)
• heparin (a medicine used to manage blood clots)
• allopurinol (a medicine used to manage gout)
• racecadotril (a medicine used to manage diarrhea)

Overdosage:

If you or anyone else accidentally took more CARDACE METO 5MG TABLET, consult your doctor immediately. Symptoms of overdose might include low blood pressure, tiredness, dizziness, slow pulse, shortness of breath, nausea, vomiting, blue colouring of the skin, low blood sugar levels and high levels of potassium in the blood.

SYNOPSIS