INTRODUCTION ABOUT ANXISET PLUS TABLET

ANXISET PLUS TABLETcontains a combination of Clonazepam and Escitalopram which belongs to the group of medicines called Antidepressants. It is indicated for the management of comorbid depression and anxiety disorder.

Comorbid depression and anxiety disorder is condition in which the person has anxiety and depression together at the same time. Symptoms are persistent feeling of sadness or loss of interest, changes in sleep, appetite, energy level, concentration or daily behavior, feeling nervous or restless, fast heartrate, heavy breathing.

Avoid consumption of alcohol during management with ANXISET PLUS TABLET. ANXISET PLUS TABLET is not recommended to use in patients having liver or heart diseases, acute narrow-angle glaucoma (increased pressure within the eye) or if you are taking MAO inhibitors such as isocarboxazid or moclobemide (to manage depression), selegiline (used to manage Parkinson’s disease) or linezolid (an antibiotic).

Before taking ANXISET PLUS TABLET inform your doctor if you have kidney, liver or, lung diseases, epilepsy, low levels of sodium, tendency of bleeding and bruising and diabetes. Patients should be monitored for signs of suicidal ideation and behaviors and advised to seek immediate medical advice if any such signs occur.

ANXISET PLUS TABLET should be used with caution in pregnant and breastfeeding women only if clearly advised by the doctor. Consult your doctor before taking it. ANXISET PLUS TABLET is not recommended for use in children and adolescents (18 years and below).ANXISET PLUS TABLET should be used with caution in elderly patients (above 65 years of age).

The most common side effects of taking ANXISET PLUS TABLET are nausea, headache, diarrhea, constipation, dry mouth, increased sweating, increased or decreased appetite, etc. Consult your doctor if any of the symptoms worsen or persists.

USES OF ANXISET PLUS TABLET

• Manage comorbid depression and anxiety disorder

HOW ANXISET PLUS TABLET WORKS

ANXISET PLUS TABLET is a combination of Clonazepam and Escitalopram, where Clonazepam is a benzodiazepine that increases the action of gamma-aminobutyric acid (GABA), a chemical messenger that suppresses the abnormal activity of the nerve cells in the brain. Escitalopram is a selective serotonin reuptake inhibitor (SSRI) that increases the levels of serotonin, a chemical messenger that improves mood.

DIRECTIONS FOR USE

Take ANXISET PLUS TABLET as advised by your physician. Swallow the medicine with water. Do not crush or chew the medication. Your physician will decide the correct dose and duration of ANXISET PLUS TABLET for you depending on your age, body weight and disease condition.

SIDE EFFECTS OF ANXISET PLUS TABLET

HOW TO MANAGE SIDE EFFECTS

Nausea:

Take ANXISET PLUS TABLET with or after meals. Stick to simple meals upon taking this medicine. Avoid eating rich or spicy food. Do not take any medication for nausea without your doctor’s consultation. Ask for your doctor’s advice if the nausea doesn’t improve.

Vomiting:

Get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Do not take any medicine for vomiting without your doctor's consultation. Contact your doctor if vomiting does not go or worsen.

Dizziness:

Lie or sit down especially when you feel dizzy. If you're feeling a severe episode of spinning(vertigo), lie in a dark and quiet place with your eyes closed. Try to avoid vehicle driving. Discuss with your doctor if the dizziness worsens.

Dry mouth:

A dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes having alcohol because they can be drying. Consult your physician for advice if your dry mouth doesn’t improve.

Loss of appetite:

Eat when you are hungry. Eat a nutritious snack rich in calories and protein, such as dried fruit and nuts. If the symptom does not improve, consult your doctor.

Constipation:

Eat more fiber-rich foods like fresh fruits, vegetables and cereals and drink plenty of water. Exercise more regularly. If the symptom does not improve, consult your doctor.

Headache:

Try to take rest and don’t involve yourself in exertive activities. Rest in a quiet and dark room. Apply a pain-relieving balm on your forehead. Ask for your doctor’s advice if headache doesn’t improve.

Diarrhea:

Drink more fluids such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without your doctor’s consultation.

WARNING & PRECAUTIONS

PREGNANCY

INTERACTIONS

A. Drug-Drug interactions:

Before taking ANXISET PLUS TABLET, inform your doctor if you are taking any of the following medicine:

• phenelzine, iproniazid, isocarboxazid, nialamide, tranylcypromine, bupropion, tryptophan, fluvoxamine, moclobemide, clomipramine, nortriptyline imipramine and desipramine, St. John’s Wort (herbal) (used to manage depression), lithium (used to manage maniac disorders), risperidone, pimozide, thioridazine and haloperidol (used to manage psychoses)
• selegiline (used to manage Parkinson’s disease)
• tramadol (used to manage moderate to severe pain), aspirin (used to relieve pain)
• sumatriptan (used to manage migraine or cluster headaches)
• omeprazole, cimetidine (used to manage stomach problems)
• ticlopidine (used to reduce the risk of stroke), flecainide, propafenone and metoprolol (used to manage heart diseases)
• warfarin, dipyridamole, phenprocoumon (used to manage blood clots)
• mefloquine (used to manage malaria)
• sparfloxacin, moxifloxacin, erythromycin IV, pentamidine (used to manage infections)
• astemizole, mizolastine (used to manage allergies)
• medicines that cause lower potassium and magnesium levels (Ex. cisplatin, gentamycin, furosemide)

Overdosage:

If you or anyone else accidentally take too much of ANXISET PLUS TABLET, consult your doctor immediately or visit the nearby hospital. The symptoms of overdosage are excessive sleepiness, confusion, dizziness and tremor.

SYNOPSIS

MORE INFORMATION

• Keep ANXISET PLUS TABLET out of reach of children
• Store ANXISET PLUS TABLET at a temperature not exceeding 30°C