INTRODUCTION ABOUT AKURIT 3 TABLET

AKURIT 3 TABLET is a combination of Ethambutol, Isoniazid and Rifampicin which belongs to the group of medicines called Antituberculosis agents respectively. It is used for the initial management of tuberculosis. Tuberculosis (TB) is a bacterial infection which spreads through inhaling tiny droplets from the coughs or sneezes of an infected person. Symptoms such as persistent cough with sputum and blood, weight loss, night sweats, high temperature, tiredness and fatigue, loss of appetite and swelling in the neck.

Your doctor will perform some regular blood tests such as liver function test, visual acuity, uric acid level to monitor any changes in your body. Avoid consumption of alcohol while taking this medicine, as it may cause liver damage. AKURIT 3 TABLET is not recommended in patients with acute liver disease, drug-induced liver disease, inflammation of the optic nerve (optic neuritis) and body weight of less than 20 kg. AKURIT 3 TABLET should be used with caution in patients with hepatitis and kidney disease, suffer from tingling in the hands and feet (peripheral neuropathy), HIV infection, hypersensitive to ethionamide or niacin (nicotinic acid), epilepsy or a history of psychiatric disease and diabetes or porphyria.

AKURIT 3 TABLET should be used with caution in pregnant and breastfeeding women. Contact your doctor before taking AKURIT 3 TABLET. The most common side effects of taking AKURIT 3 TABLET are peripheral neuropathy (sensations of tingling, pricking, or numbness of the skin, especially in the feet and hands), increased liver enzymes & uric acid levels in blood, flushing, reddish discoloration of body fluids such as urine, sputum, tears, saliva and sweat, diarrhoea, abdominal pain, loss of appetite, nausea, and vomiting or skin reactions. Consult your physician if you experience any of the above side effects worsen.

USES OF AKURIT 3 TABLET

• Used to manage tuberculosis

HOW AKURIT 3 TABLET WORKS

AKURIT 3 TABLET helps to manage tuberculosis, where Ethambutol has bacteriostatic properties that inhibits cell wall synthesis. Isoniazid destroys and manages the growth of bacteria. Rifampicin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.  

DIRECTIONS FOR USE

Take AKURIT 3 TABLET as advised by your physician. Take the medicine, with a glass of water. Do not crush or chew the medicine. Your doctor will decide the right dose depends on your age, body weight and severity of infection.

SIDE EFFECTS OF AKURIT 3 TABLET

HOW TO MANAGE SIDE EFFECTS

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking AKURIT 3 TABLET inform your doctor if you are taking any of the following medicines:

• antibiotics such as voriconazole, clarithromycin (medicine used to manage fungal infections) 
• HIV protease inhibitors (Ex. efavirenz, nevirapine) (drugs used to manage HIV infection)
• aluminium hydroxide (medicine used to manage diseases related to the gastric acid)
• disulfiram (medicine used for the management of chronic alcoholism)
• medicines to manage fungal infections (Ex. ketoconazole, fluconazole)
• quinine (medicine used to manage malaria)
• immunosuppressant drugs (Ex. cyclosporine, tacrolimus)
• medicines to manage heart conditions (Ex. verapamil, digoxin)
• medicines to manage blood lipids (Ex. simvastatin)
• medicines to manage diabetes (Ex. glibenclamide)
• oral contraceptive pills (medicines used to manage unwanted pregnancy)
• medicines to manage epileptic seizures (Ex. phenytoin, carbamazepine, valproate)
• medicines used to help you sleep (Ex. diazepam, flurazepam, triazolam, midazolam)
• medicines for the management of certain psychiatric conditions (Ex. chlorpromazine, haloperidol)
• medicines for management of blood clots (Ex. warfarin)
• medicines used at surgery (Ex. alfentanil, enflurane)
• corticosteroids (Ex. prednisolone, medicines for the management of inflammations and other diseases, such as asthma or rheumatoid arthritis)
• paracetamol (used for pain)

B. Drug-Food interaction:

When taken with cheese or fish, AKURIT 3 TABLET may cause redness, itching of the skin, hot feeling, rapid or pounding heartbeat, sweating, chills or clammy feeling, headache, and/or light-headedness.

Overdosage:

If you or anyone else accidentally takes too much of AKURIT 3 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose may develop vomiting, gastrointestinal disturbances, fever, headache, dizziness, slurring of speech, hallucinations and/or visual disturbances.  

SYNOPSIS