INTRODUCTION ABOUT ZERODOL-SP TABLET

ZERODOL-SP TABLET is a pain relief combination used to provide relief from pain, inflammation and swelling associated with joint pain, muscle pain, post-operative conditions, etc.

It contains a combination of Aceclofenac, paracetamol and serratiopeptidase as active ingredients. Aceclofenac and Paracetamol are pain relieving medicines which works by blocking the release of certain chemicals in the body that causes pain, inflammation and swelling. Serratiopeptidase is a protein-breaking enzyme which breaks down the abnormal proteins at the site of inflammation, thereby healing the affected areas.

Before taking Zerodol-SP, inform your doctor if you have any stomach disease like ulcerative colitis, Crohn’s disease, bleedings or perforation in the gut, bloody stools or vomits, etc. You must also inform your doctor if you have asthma, liver, kidney or heart problems as a precaution.

Do not use this medicine if you are pregnant or breastfeeding without consulting your doctor. The most common side effects of Zerodol-SP are dizziness, nausea, vomiting, diarrhoea, constipation, mouth ulcers, increased liver enzymes in the blood, indigestion, bloating, stomach irritation, increase in blood urea or creatinine levels.

USES OF ZERODOL-SP TABLET

• Pain, inflammation and swelling associated with joint pain, muscle pain and post-surgical conditions

HOW ZERODOL-SP TABLET WORKS

It contains a combination of Aceclofenac, Paracetamol, and Serratiopeptidase. Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that blocks the enzyme (COX) responsible for producing prostaglandins, chemicals in the body that cause pain and inflammation. By inhibiting this enzyme, aceclofenac reduces pain and swelling.

Paracetamol works by reducing the intensity of pain signals sent to the brain and helps regulate body temperature, acting as both a pain reliever and fever reducer. Serratiopeptidase is an enzyme that breaks down proteins involved in inflammation and promotes the removal of dead tissue, reducing swelling and improving healing.

Together, these components help reduce pain, inflammation, and swelling effectively in conditions like arthritis, muscle pain, and joint pain.

DIRECTIONS FOR USE

• Swallow this medicine with a glass of water
• Do not chew or crush the medicine
• Take the tablet as prescribed by your doctor, usually 1 to 2 times a day as advised by the physician
• It is best to take Zerodol-SP with or after food to minimize the risk of stomach upset or irritation.
• If you miss a dose, take it as soon as you remember. If it's almost time for the next dose, skip the missed one. Do not double the dose to catch up.
• Use it only for the duration prescribed by your doctor. Avoid long-term use without medical supervision to prevent side effects.
• Always consult your healthcare provider for personalized advice based on your health condition

SIDE EFFECTS OF ZERODOL-SP TABLET

Common Side Effects of Zerodol-SP Tablet

• Dizziness
• Nausea or vomiting
• Diarrhoea or constipation
• Increased liver enzymes in the blood
• Wind, Inflammation or irritation of the lining of the stomach 
• Mouth ulcers
• Skin rashes or Itching, skin inflammation
• Raised circular red itchy, stinging or burning patches on the skin (hives)
• Increase in blood urea levels
• Increase in blood creatinine level

Stop taking this medicine and contact your doctor if you experience any of the following side effects:

• Allergic reactions (such as fever, difficulty breathing, wheezing, abdominal pain, vomiting, swelling of the face and throat)
• Severe skin reactions with fever, peeling of skin, severe body pains and joint pains
• Symptoms include high fever, headache, vomiting, blotchy red rashes, neck stiffness, sensitivity and intolerance to light.
• Passing blood in your faeces or black tarry stools, vomiting of any blood or dark particles that look like coffee grounds.
• Indigestion or heartburn, pains in your stomach or other abnormal stomach symptoms.
• Low RBC, WBC and platelet count

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interactions:

• NSAIDs (Ex. aspirin, naproxen, rofecoxib, ibuprofen, and diclofenac)
• Antihypertensives (Ex. atenolol, metoprolol)
• Diuretics (Ex. chlorothiazide, chlorthalidone)
• Cardiac glycosides (Ex.  digoxin)
• Anti-manic (Ex. lithium)
• Anti-rheumatic (Ex. methotrexate)
• Immunosuppressants (Ex. ciclosporin and tacrolimus)
• Anti-progestational steroids (Ex. mifepristone)
• Corticosteroids (Ex. cortisone, prednisone, and prednisolone)
• Anticoagulants (Ex. warfarin, rivaroxaban, dalteparin, enoxaparin, heparin, and dabigatran)
• Antibiotics (Ex. ciprofloxacin and chloramphenicol)
• Anti-retroviral (Ex. zidovudine)
• Antidiabetic agents (Ex. biguanides, sulfonylureas)
• Antiglaucoma agents (Ex. acetazolamide)
• Anti-gout (Ex. probenecid)
• Antiepileptic medicines (Ex. phenytoin, phenobarbital, carbamazepine)
• Anti-tubercular (Ex. rifampicin)
• Anti-depressant (Ex. St. John's wort)
• Anti-platelet (Ex. clopidogrel)

Overdosage:

If you or anyone else accidentally takes too much of Zerodol-SP Tablets, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose are headache, pallor, nausea, vomiting, epigastric pain, gastrointestinal irritation and bleeding, diarrhea, disorientation, excitation, drowsiness, dizziness, tinnitus, hypotension, respiratory depression, fainting, convulsions, anorexia, and/or abdominal pain.

SYNOPSIS

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