INTRODUCTION ABOUT XIDORIN TABLET

XIDORIN TABLET contains Midodrine which belongs to the group of medicines called Alpha -1 Selective Adrenergic Receptor Agonist. It is used to manage low blood pressure (hypotension) in adults. Symptoms of low blood pressure include blurred or fading vision, dizziness or light-headedness, fainting, feeling sick, difficult in concentrating.

Midodrine acts on the blood vessels via the sympathetic nervous system (part of nervous system that cause increase in heart rate, blood pressure, breathing rate, and dilatation of pupil) to correct imbalances of blood distribution, such as preventing too much blood pooling in the legs when standing up which may cause low blood pressure. Your doctor may regularly monitor the blood pressure when you are lying down and when you are standing up as there may be a risk of your blood pressure rising when you lie down (Ex. at night).

XIDORIN TABLET is not recommended for use in patients having severe heart disease.XIDORIN TABLET should be used with caution in patient having severe kidney disease, liver problems. Consult your doctor for advice before takingXIDORIN TABLET, if you are pregnant or breast-feeding.XIDORIN TABLET is not recommended for use in children and adolescents below the age of 18 years. The most common side effects of takingXIDORIN TABLET are increased blood pressure when lying down, headache, nausea (feeling sick), vomiting, heartburn. Consult your doctor if the symptom worsens.

USES OF XIDORIN TABLET

• Used to manage certain severe forms of low blood pressure in adults by increasing the blood pressure

HOW XIDORIN TABLET WORKS

XIDORIN TABLET acts on the blood vessels via the sympathetic nervous system (part of nervous system that cause increase in heart rate, blood pressure, breathing rate, and dilatation of pupil) to correct the imbalances of blood distribution, such as preventing too much blood pooling in the legs when standing up which may cause low blood pressure.

DIRECTIONS FOR USE

TakeXIDORIN TABLET as advised by your physician. Swallow this medicine, do not crush, or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF XIDORIN TABLET

HOW TO MANAGE SIDE EFFECTS

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

• Reserpine and guanethidine (medicines used to reduce high blood pressure)
• Antihistamines like cetirizine, chlorpheniramine (used to manage allergies)
• Hormones for the thyroid like thyroxine
• Tricyclic antidepressants like clomipramine, amoxapine, amitriptyline and MAO-inhibitors such as selegiline, isocarboxazid, phenelzine, (both used to manage depression)
• Vasoconstrictors like epinephrine, dopamine, phenyl epinephrine (medicines that narrow blood vessels)
• Sympathomimetic agents such as ephedrine, isoproterenol, metaproterenol, (medicines that have a stimulating effect on certain parts of the nervous system)
• Prazosin and phentolamine (medicines used to manage heart disease
• Digitalis preparations such as digitoxin, digoxin (medicines used to manage heart disease)
• Fludrocortisone acetate (medicine used to reduce inflammation)
• Perphenazine (medicine used to manage mental or mood disorders)
• Amiodarone (medicine used to manage irregular heartbeat)
• Metoclopramide (medicine used to prevent vomiting)

Overdosage:

If you or anyone else accidentally take too much ofXIDORIN TABLET, consult your doctor immediately or visit the nearby hospital. The most common symptoms of overdose are high blood pressure (hypertension), slow heart rate (bradycardia), difficulty urinating and feeling of coldness.

SYNOPSIS

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