COMMON

• headache
• sleep disorders
• clumsiness or unsteadiness
• trembling of hands and arms
• nervousness
• changing moods
• blurred vision
• ringing in ears
• deafness
• dizziness
• flu
• abdominal or stomach pain
• heartburn
• nausea and vomiting
• diarrhoea
• skin rash
• hair loss or thinning of hair
• back pain
• change in menstrual periods
• lack or loss of strength
• mental confusion
• aggression
• convulsion
• memory problems
• becoming unreactive
• bedwetting
• signs of liver damage such as skin and eyes that appear yellowish (jaundice), abdominal pain and swelling.
• signs of inflammation of the pancreas (pancreatitis) such as upper abdominal pain, abdomen tenderness, fever and rapid pulse
• signs of Fanconi syndrome (a disorder of kidney tubes) such as excessive thirst, urination, vomiting
• overgrown gum tissue
• agitation
• disturbance in attention
• abnormal behaviour
• hyperactivity
• learning disorder

UNCOMMON

• unusual bleeding or bruising
• abnormal dreams
• anxiety
• feeling sad
• irritability
• pain in joints
• cough
• constipation
• dry eyes
• spots before the eyes
• ear infection
• ear pain
• runny nose
• dental pain
• bloating
• muscle pains or stiffness
• tiredness
• weight gain or loss
• learning disorder
• coma
• loss of muscle control
• brittle bones and fractures
• shortness of breath
• chest pain
• blood clotting problems

RARE

Stop taking VALPROL CR 500MG TABLET and contact your doctor if you experience any of the following side effects:    

• signs of allergic reactions such as swelling of the face, lips, eyelids, throat and tongue, which may cause difficulty in breathing and swallowing
• signs of altered levels of ammonia in the blood characterized by vomiting, balance issues and lack of alertness
• signs of liver problems characterized by nausea, vomiting, tiredness, sleepiness, weakness, stomach pain, yellowing of the skin or whites of the eye
• signs of inflammation of the pancreas characterized by acute abdominal pain
• chest pain
• shortness of breath
• hallucinations
• suicidal thoughts
• psychosis (mental disorder causing disconnection from reality)
• toxic epidermal necrolysis (life-threatening skin disorder causing widespread skin pain, rashes, blisters, sores and crusting)
• Steven-Johnson syndrome (a skin disorder characterized by painful rashes and blisters on the skin)
• anaphylaxis (severe allergic reaction characterized by shortness of breath, fainting or fastened heartbeat)
• erythema multiforme (a skin condition characterized by raised red rashes on the skin)
• polycystic ovarian syndrome (a disorder of ovaries characterized by irregular periods, hair growth on the skin, acne and weight gain)
• brain diseases such as cerebral pseudo atrophy (loss of brain cells), encephalopathy (disease altering brain structure and functions) and coma (loss of consciousness)
• signs of thrombocytopenia (a condition marked by decreased platelet count) such as spontaneous bruising or bleeding
• signs of agranulocytosis (severe decrease of white blood cells or bone marrow failure) such as fever and breathing difficulty
• signs of anaemia (decreased red blood cell count) as weakness, dizziness, pale skin and shortness of breath
• signs of macrocytosis (abnormally increased red blood cell size) such as brittle nails, loss of weight or diarrhoea
• signs of pancytopenia (decreased blood cells and platelets) such as weakness, dizziness, pale skin and shortness of breath
• drowsiness
• change in consciousness level (including coma)
• confusion
• memory loss
• abnormal behaviour such as changes in attention, concentration, mood, hallucinations or fits of more frequency and severity
• signs of hypothyroidism (underactive thyroid gland) such as tiredness or weight gain
• signs of pleural effusion (build-up of fluid between the tissues that line the lungs and the chest) such as breathing difficulty and pain
• increase in the number and severity of convulsions
• signs of rhabdomyolysis (a disorder caused by the breakdown of muscle tissue) such as muscle pain and weakness
• signs of systemic lupus erythematosus (autoimmune disorder) such as joint pain, fever, fatigue or rash
• signs of increased ammonia in the blood, such as problems in balancing and co-ordination, feeling lethargic or less alert associated with vomiting
• shakiness (tremor)
• jerky muscle movements
• unsteadiness when walking due to parkinsonism (brain disorder), extrapyramidal disorder or ataxia (a disorder marked by impaired coordination)
• uncontrollable and rapid movement of the eyes
• signs of kidney disease such as renal failure, tubulointerstitial nephritis such as blood in the urine, fever, increased or decreased urine output, weakness, confusion
• signs of Fanconi syndrome (a disorder of kidney tubes) such as excessive thirst, urination and vomiting manifest as reduced urinary output or blood in the urine
• signs of decreased blood sodium levels such as confusion
• confusion that occurs due to decreased sodium levels in blood and syndrome of Inappropriate Antidiuretic Hormone (SIADH) secretion (a condition marked by high levels of the antidiuretic hormone that causes retention of water in the body)

OTHERS

VALPROL CR 500MG TABLET is not recommended for use if you:

• have porphyria (a hereditary disease that affects the skin or nervous system)
• have blood coagulation or clotting disorders such as deep vein thrombosis, pulmonary embolism 
• have pancreatic diseases
• have signs of urea cycle disorder (excessive ammonia build-up in the body) such as loss of appetite, vomiting and lethargy that causes excessive ammonia builds up in the body
• have a genetic disorder called Alpers-Huttenlocher syndrome (a progressive, neurodevelopmental syndrome characterized by three co-occurring clinical symptoms which are psychomotor regression (dementia); seizures; and liver disease)

Before taking VALPROL CR 500MG TABLET, inform your doctor if you:           

• have diabetes
• are scheduled for surgery such as dental surgery
• have systemic lupus erythematosus (a disease of the immune system that affects bones, joints and body organs)
• have a certain brain disease or any metabolic condition affecting your brain such as hypoglycaemic encephalopathy
• have a deficiency condition such as carnitine palmitoyl transferase type II deficiency (a condition that manages the body from using certain fats for energy, particularly during periods without food)

Use in Paediatrics:

VALPROL CR 500MG TABLET should be used with caution in children (below 2 years of age). Consult your doctor before taking VALPROL CR 500MG TABLET.

Use in Geriatrics:

VALPROL CR 500MG TABLET should be used with caution in elderly patients (aged above 68 years). Consult your doctor before taking VALPROL CR 500MG TABLET.