INTRODUCTION ABOUT SILODAL D 4 CAPSULE

SILODAL D 4 CAPSULE is a combination of Silodosin + Dutasteride formulated to provide effective relief from urinary symptoms caused by an enlarged prostate (Benign Prostatic Hyperplasia). It helps alleviate signs like frequent urination, especially at night (nocturia), a weak or interrupted urine flow, difficulty starting urination, and a feeling of incomplete bladder emptying.

Take SILODAL D 4 CAPSULE at the same time every day, swallowing it whole without breaking, chewing, or crushing it. Your doctor will determine the appropriate dosage for you. To maximize its effectiveness, take it consistently and avoid missing doses, even if you feel better. It may take up to 4 weeks to notice significant symptom relief. If your symptoms do not improve or worsen, inform your doctor.

This medication is not suitable for women or children. Before taking SILODAL D 4 CAPSULE, inform your doctor if you have low blood pressure, or liver or kidney conditions, as it may not be appropriate for you. Additionally, it can interact with other medications, so ensure your doctor is aware of all medicines you are taking.

You may be advised to use condoms during sexual activity and to monitor your blood pressure regularly. Speak with your healthcare provider if you consume alcohol, as it could affect how this medicine works.

Men taking SILODAL D 4 CAPSULE should not donate blood for at least 6 months after their last dose, in order to manage the exposure of the medicine to pregnant women via blood transfusion. Avoid consumption of alcohol while taking SILODAL D 4 CAPSULE, as it may lower your blood pressure.

The most common side effects of this medicine include reduced libido, difficulty achieving an erection (impotence), breast tenderness, and breast enlargement.

Dizziness and drowsiness may also occur, especially when starting the treatment. If these side effects persist or bother you, consult your doctor for guidance. Remember, the benefits of this medicine are considered to outweigh the risks of potential side effects.

USES OF SILODAL D 4 CAPSULE

Urinary symptoms of benign prostatic hyperplasia such as:

• Frequent urination
• Weak Urine Flow
• Difficulty Starting Urination
• Incomplete Bladder Emptying
• Urgency to Urinate
• Dribbling After Urination
• Straining During Urination
• Urinary Retention

Benefits of SILODAL D 4 CAPSULE in BPH:

• Relieves difficulty in urination
• Improves urine flow and bladder control
• Reduces frequent nighttime urination (nocturia)
• Helps shrink the enlarged prostate gland over time

HOW SILODAL D 4 CAPSULE WORKS

SILODAL D 4 CAPSULE is a combination of two active ingredients, Silodosin and Dutasteride, that work together to manage the symptoms of an enlarged prostate (Benign Prostatic Hyperplasia or BPH):

1. Silodosin: This is an alpha-blocker that relaxes the muscles in the prostate gland and bladder neck. By improving muscle relaxation, it helps enhance urine flow and reduces urinary symptoms such as frequent urination, difficulty starting urination, and incomplete bladder emptying.
2. Dutasteride: This is a 5-alpha reductase inhibitor that reduces the production of dihydrotestosterone (DHT), a hormone responsible for prostate growth. Over time, this helps shrink the prostate gland, alleviating pressure on the bladder and urethra.

By combining these actions, SILODAL D 4 CAPSULE effectively manages urinary symptoms of BPH, improving quality of life and reducing the risk of complications like urinary retention. For best results, it should be taken as prescribed by your doctor.

DIRECTIONS FOR USE

• Take SILODAL D 4 CAPSULE once daily, preferably after a meal to reduce the risk of stomach upset.
• Swallow the medicine with a glass of water. Do not crush or chew.
• Consistency is key for best results, take at the same time every day.

Dosage and Administration:

• Initial Dosage: One dose per day, as directed by your physician.
• Adjustments: Dosage adjustments should only be made under a doctor's supervision based on your condition and response to treatment.
• Duration: Follow your healthcare provider’s recommendation for how long you should take SILODAL D 4 CAPSULE.

Missed Dosage Instructions for SILODAL D 4 CAPSULE:

• If you forgot a dose of SILODAL D 4 CAPSULE, take it as soon as you remember, unless it is almost time for the next dose.
• Do not take two doses at once to make up for a missed dose.

Overdosage instructions for SILODAL D 4 CAPSULE:

• In case of an overdose, contact your doctor or seek emergency medical attention immediately.
• Symptoms of overdose may include dizziness, fainting, and abnormal heartbeats.
• Treatment of overdose may involve supportive care depending on the severity of the symptoms.

Misuse, Drug Abuse, and Dependence:

• SILODAL D 4 CAPSULE is not intended for misuse or abuse. It is a prescription medication that should only be used as directed by your healthcare provider.
• There is no known risk of physical dependence or addiction with SILODAL D 4 CAPSULE, but misuse can lead to ineffective results or side effects.

SIDE EFFECTS OF SILODAL D 4 CAPSULE

Like all medicines SILODAL D 4 CAPSULE may cause certain side effects, although not everybody gets them.

Common side effects of SILODAL D 4 CAPSULE are

• Dizziness, Headache
• Ejaculation Problems
• Fatigue
• Decreased Libido
• Breast Tenderness, breast enlargement or pain
• Nausea, abdominal discomfort, or diarrhea
• trouble getting or keeping an erection (impotence)
• nasal congestion
• low blood pressure while standing up from sitting or lying position

When to Consult your doctor?

Stop taking SILODAL D 4 CAPSULE and contact your doctor immediately if you experience any of the following side effects:

• Allergic Reactions: Severe allergic reactions like rash, itching, or swelling of the face or throat may occur, though rare. If any of these signs occur, immediate medical attention is necessary.
• Breast Changes: Rarely, users may experience more noticeable breast enlargement or tenderness.
• Prolonged Erection (Priapism): A rare but serious side effect that requires immediate medical attention if an erection lasts more than 4 hours.

HOW TO MANAGE SIDE EFFECTS

WARNING & PRECAUTIONS

SAFETY ADVICE

Expert Advice to Maximize the Effects of SILODAL D 4 CAPSULE:

• Follow Your Doctor’s Instructions: Take SILODAL D 4 CAPSULE exactly as prescribed. Do not change your dose or stop the medication without consulting your doctor, even if you feel better, to ensure consistent results and prevent symptom recurrence.
• Establish a Routine: Take the medicine at the same time every day to maintain consistency. Skipping doses can reduce effectiveness and delay symptom improvement.
• Take with a Light Meal: For better absorption, take SILODAL D 4 CAPSULE with a light meal. Avoid high-fat meals as they may increase drug levels and the risk of side effects.
• Monitor Blood Pressure: Silodosin may cause dizziness or low blood pressure, especially at the start of treatment. Regularly check your blood pressure, particularly if you take antihypertensive medications. Consult your doctor if you feel faint or dizzy.
• Stay Hydrated: Drink plenty of water to help prevent urinary discomfort and manage BPH symptoms.
• Limit Alcohol: Alcohol can increase the risk of side effects like dizziness and drowsiness when combined with SILODAL D 4 CAPSULE. Limit or avoid alcohol during treatment.
• Avoid Grapefruit: Grapefruit and its juice can interfere with the medication's metabolism, increasing the risk of side effects. Avoid grapefruit while taking SILODAL D 4 CAPSULE.
• Regular Check-ups: Keep regular appointments with your doctor to track progress and adjust treatment as needed. It may take several weeks to see significant symptom relief.
• Inform Your Doctor About Other Medications: Always inform your doctor about any other medications, including over-the-counter drugs and supplements, to avoid drug interactions that may affect the effectiveness or increase the risk of side effects.

INTERACTIONS

Drug-Drug interactions:

1. Alpha-blockers: When SILODAL D 4 CAPSULE is taken with other alpha-blockers (e.g., Tamsulosin), the risk of low blood pressure (hypotension), dizziness, and fainting increases. Combining these medications may lead to a stronger reduction in blood pressure.
2. CYP3A4 Inhibitors: Drugs such as Ketoconazole, Itraconazole, and certain antifungal medications can increase Silodosin levels in the body, potentially leading to an increased risk of side effects like dizziness, drowsiness, and low blood pressure.
3. CYP3A4 Inducers: Drugs like Rifampin, Carbamazepine, and certain anticonvulsants can reduce the effectiveness of Silodosin by increasing its metabolism, decreasing its therapeutic effects.
4. Prostate Cancer Medications: Combining SILODAL D 4 CAPSULE with other medications used to treat prostate cancer, such as Finasteride, may cause an overlap in their effects, leading to increased risks of side effects or complications related to prostate gland activity.
5. Antihypertensives: Combining SILODAL D 4 CAPSULE with blood pressure-lowering medications (e.g., ACE inhibitors, Beta-blockers) may lead to an excessive drop in blood pressure, resulting in dizziness, lightheadedness, and fainting, particularly when standing up.

Drug-Food Interactions

1. Grapefruit: Grapefruit and grapefruit juice can affect the metabolism of Silodosin, increasing its levels in the bloodstream. This can heighten the risk of side effects like dizziness, fatigue, and hypotension. It’s best to avoid grapefruit products while taking SILODAL D 4 CAPSULE.
2. Fatty Foods: Consuming high-fat meals with SILODAL D 4 CAPSULE may increase the absorption of Silodosin, leading to higher levels of the drug in the body and a greater likelihood of side effects. It’s advisable to take this medication with a light meal.
3. Alcohol: Alcohol can increase the risk of side effects like dizziness, drowsiness, and low blood pressure when combined with SILODAL D 4 CAPSULE. It’s recommended to limit alcohol intake while on this medication.

SYNOPSIS

MORE INFORMATION

Lifestyle Changes to Complement SILODAL D 4 CAPSULE for BPH:

• Stay Active: Engage in regular physical activity, such as walking or swimming, to improve urinary function and overall health.
• Maintain a Healthy Weight: Losing excess weight can reduce pressure on the prostate and improve urinary symptoms.
• Limit Caffeine and Alcohol: These can irritate the bladder and worsen urinary symptoms. Consider reducing or eliminating them from your diet.
• Practice Bladder Training: Try to extend the time between urinations gradually to improve bladder control.
• Stay Hydrated: Drink plenty of water throughout the day, but reduce fluid intake before bed to avoid frequent nighttime urination (nocturia).
• Manage Stress: Practice relaxation techniques such as deep breathing, meditation, or yoga to reduce stress, which can negatively impact urinary health.
• Avoid Heavy Lifting: Straining can worsen BPH symptoms. Practice good posture and avoid heavy lifting that can put pressure on the pelvic area.
• Eat a Balanced Diet: A diet rich in fruits, vegetables, and healthy fats can support prostate health and overall well-being.
• Quit Smoking: Smoking can worsen urinary symptoms and impact circulation. Quitting may improve overall health and symptoms of BPH.