INTRODUCTION ABOUT SGLTD S 10/100 TABLET

SGLTD S 10/100 TABLET is used to manage type II diabetes mellitus which is inadequately controlled on metformin monotherapy. It is a combination of Dapagliflozin and Sitagliptin which belongs to the group of medicines called Antidiabetic agents. It effectively controls blood sugar levels where dapagliflozin inhibits SGLT2, increasing urinary glucose excretion and reducing blood levels of glucose and Sitagliptin inhibits DPP-4, increases glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), resulting in increased insulin synthesis and decreased glucagon release.

SGLTD S 10/100 TABLET is not recommended for use in patients having severe kidney problems or those on dialysis. Before taking the medicine, inform your doctor if you have inflammation of the pancreas, gallstones, alcohol dependence, or very high levels of triglycerides in the blood or any heart, kidney or liver problems. It should be used in pregnant women only if considered clearly necessary. It should be used with caution in breastfeeding women. Safety and effectiveness of SGLTD S 10/100 TABLET in children and adolescents (under 18 years of age) have not been established.

It is important to stay on the diet and exercise recommended by your doctor while taking SGLTD S 10/100 TABLET as it can help the body use its blood sugar better. The most common side effects are headache, flatulence and constipation. Consult your doctor if any of the side effects worsen or persist for a longer period of time.

USES OF SGLTD S 10/100 TABLET

• Used to manage type II diabetes mellitus (which is inadequately controlled on metformin monotherapy)

HOW SGLTD S 10/100 TABLET WORKS

SGLTD S 10/100 TABLET effectively controls blood sugar levels where Dapagliflozin inhibits SGLT2, increasing urinary glucose excretion and reducing blood levels of glucose and Sitagliptin inhibits DPP-4, increases glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), resulting in increased insulin synthesis and decreased glucagon release.

DIRECTIONS FOR USE

• Take SGLTD S 10/100 TABLET as advised by your physician
• Swallow the medicine with a glass of water. Do not crush or chew the medicine
• It can be taken with or without food
• Your doctor will decide the correct dose and duration of SGLTD S 10/100 TABLET therapy depending on your age, body weight and disease condition.

SIDE EFFECTS OF SGLTD S 10/100 TABLET

Common Side Effects of SGLTD S 10/100 TABLET:

• flatulence, constipation, stomach pain, diarrhea
• swelling of hands or legs
• headache, dizziness
• stuffy or runny nose, sore throat
• passing urine more often
• dry mouth

Stop taking SGLTD S 10/100 TABLET and contact your physician immediately if you experience any of the following side effects:

• inflamed pancreas (severe and persistent stomach pain that might reach through the back with or without nausea and vomiting)
• serious allergic reaction (rash, hives, blisters on the skin or peeling skin and swelling of the lips, tongue, face and throat that may cause difficulty in breathing or swallowing)
• diabetic ketoacidosis (increased levels of ketone bodies in urine or blood, nausea or vomiting, stomach ache, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to breathe, a sweet or metallic taste in the mouth or a different odor in urine or sweat, rapid weight loss)
• urinary tract infection (fever, chills, burning sensation when passing urine, pain in the back or side, blood in urine)
• low blood sugar levels (shaking, sweating, feeling very anxious, fast heartbeat, feeling hungry, headache, change in vision, and a change in mood or feeling confused)

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking SGLTD S 10/100 TABLET, inform your doctor if you are taking any of the following medicines:

• Anti-fungal (Ex. ketoconazole, itraconazole)
• Anti-viral agents (Ex. Ritonavir)
• Antibiotics (Ex. Clarithromycin)
• Immunosuppressants (Ex. Ciclosporin)
• Cardiac glycosides (Ex. Digoxin)
• Diuretics (Ex. hydrochlorothiazide, furosemide)
• Anti-diabetics (Ex. metformin, insulin, glimepiride)

Overdosage:

If you or anyone else accidentally takes too much of SGLTD S 10/100 TABLET, consult your doctor or visit a nearby hospital immediately.

SYNOPSIS