INTRODUCTION

PRUEASE 1MG contains Prucalopride which belongs to the group of medicines called Gastrointestinal prokinetics. It is used to manage long standing/chronic constipation in adults in whom conventional medicines used to manage constipation (laxatives) are ineffective. Constipation is a condition that occurs when bowel movements become less frequent, and stools become difficult to pass which generally occurs due to changes in diet or inadequate intake of fibre food. It is characterized by symptoms such as hard, dry, or lumpy stools that are painful or difficult to pass; or having a feeling that stool has not passed at all.

Prucalopride is a gastrointestinal prokinetic agent that works by activating certain receptors in the intestinal walls that cause contractions in the walls resulting in increased frequency of passing stools in the constipated individuals, thereby providing relief from constipation.

PRUEASE 1MG is not recommended for use in patients undergoing renal dialysis. It is also not recommended for use in patients suffering from perforation/obstruction of the gut wall, severe inflammation of the intestinal tract (such as crohn’s disease, ulcerative colitis or toxic megacolon/megarectum) and in patients who had recent bowel surgery. It should be used with caution in patients with heart disease, serious lung disease, severe kidney or liver disease.

PRUEASE 1MG is not recommended for use in pregnant and breastfeeding women. It is also not recommended for use in children and adolescents (below 18 years of age). The common side effects associated with the use of PRUEASE 1MG are headache, nausea, diarrhoea, abdominal pain, decreased appetite, dizziness, and vomiting. Contact your doctor or nearby hospital if any of the condition worsens.

USES OF PRUEASE 1MG

• Manages chronic constipation in adults

HOW PRUEASE 1MG WORKS

PRUEASE 1MG helps in relieving constipation, where prucalopride works by activating certain receptors in the intestinal walls causing contractions which results in increased frequency of passing stools in constipated individuals, thereby providing relief from constipation.

DIRECTIONS FOR USE

Take PRUEASE 1MG as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and severity of the condition.

SIDE EFFECTS OF PRUEASE 1MG

HOW TO MANAGE SIDE EFFECTS

Diarrhoea:

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to manage diarrhoea and consult your doctor if the symptom gets worse.

Nausea or vomiting:

Try to take PRUEASE 1MG with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.

Decreased appetite:

Eat when you feel hungry. Eat smaller meals frequently than usual. Snack only when you're hungry. Eat a nutritious snack which is rich in calories and protein, such as dried fruit and nuts. Consult your doctor if the symptom gets worse.

Headache:

Take rest and drink plenty of water. Avoid taking alcohol and skipping meals. Do not strain your eyes by watching screen for long time. Consult your doctor if the condition persists for long or gets worsened.

Dizziness:

Lie down until dizziness passes away and get up slowly. Do not bend down suddenly. Get a lot of rest. Walk slowly and carefully. Take plenty of fluids. Avoid drinking alcohol or smoking. Consult your doctor if the condition persists for long or gets worsened.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interactions

Before taking PRUEASE 1MG, inform your doctor, if you are taking any of the following medicines:

• medicines used to manage fungal infections Ex. ketoconazole
• medicines used to manage bacterial infections Ex. erythromycin
• atropine (used to manage symptoms of low heart rate)
• warfarin (medicine used for preventing blood clots)
• digoxin (medicine used to manage heart failure and abnormal heart rhythms)
• paroxetine (medicine used to manage depression, panic attacks, obsessive-compulsive disorder, anxiety disorders, and post-traumatic stress disorder)
• oral contraceptives such as ethinyl estradiol, norethindrone (used to prevent pregnancy)

Overdosage:

If you or anyone else accidentally takes too much of PRUEASE 1MG, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are diarrhoea, headache and nausea.

SYNOPSIS

MORE INFORMATION

• Keep the medicine out of reach in children
• Store PRUEASE 1MG at room temperature