INTRODUCTION ABOUT PROLOMET AM 50MG TABLET

PROLOMET AM 50MG TABLET is a combination of Amlodipine and Metoprolol which belongs to the group of medicines called Anti-hypertensives. It is used to manage (hypertension). It is a condition in which the force of the blood against the blood vessel walls is too high which is characterized by symptoms such as headache, irregular heartbeat, vision changes, feeling of overtiredness, nausea, vomiting, confusion, anxiety and chest pain.

During management with PROLOMET AM 50MG TABLET practice regular exercise (such as walking), eating healthy and salt-restricted diet and managing weight will also help to control your blood pressure effectively. Avoid taking grapefruit or its juice while taking PROLOMET AM 50MG TABLET as it may increase the blood pressure lowering effect of this medicine.

PROLOMET AM 50MG TABLET is not recommended for use in patients with lungs problems (such as asthma, chronic obstructive pulmonary disease), kidney disease or failure, liver disease, heart problems (such as heart conduction or rhythm problems, severe or uncontrolled heart failure), metabolic acidosis and low blood pressure.

Before taking PROLOMET AM 50MG TABLET, inform your doctor if you have controlled heart failure and slow heart rate, diabetes mellitus, blood vessel disorder, psoriasis (severe skin rashes), myasthenia gravis and hypertensive crisis (severe increase in blood pressure).

PROLOMET AM 50MG TABLET is not recommended for use in pregnant and breast-feeding women. PROLOMET AM 50MG TABLET is not recommended for use in children and adolescents (aged under 18 years). It should be used with caution in elderly patients (aged 65 years and above).

The most common side effects of taking PROLOMET AM 50MG TABLET are dizziness, headache, tiredness, nausea, slow heart rate or stomach pain. Consult your doctor if any of the side effects worsen.

USES OF PROLOMET AM 50MG TABLET

•  Manages High Blood Pressure (hypertension)

HOW PROLOMET AM 50MG TABLET WORKS

PROLOMET AM 50MG TABLET helps to reduce high blood pressure, where amlodipine works by inhibiting the movement of calcium ions into both vascular smooth muscle and cardiac muscle resulting in lower blood pressure by relaxing the blood vessels and improving the flow of blood to the heart muscles. Metoprolol works by reducing the force of contraction of the heart muscles by the blocking the effects of certain hormones called adrenaline and making the heart to beat more easily thus it lowers the blood pressure.

DIRECTIONS FOR USE

Take PROLOMET AM 50MG TABLET as advised by your physician. Swallow PROLOMET AM 50MG TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF PROLOMET AM 50MG TABLET

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Stick to simple meals while taking this medicine. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.

Headache:

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.  

Tiredness:

Drink plenty of fluid and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule. Consult your doctor if the symptom does not improve.

Diarrhea:

Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for managing diarrhea. Consult your doctor if the symptom did not improve.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-manage on your own and consult your doctor if the symptom did not improve on its own.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking PROLOMET AM 50MG TABLET inform your doctor, if you are taking or receiving any of these medicines:

• verapamil, nifedipine, diltiazem, hydralazine, clonidine or prazosin (used to manage high blood pressure)
• monoamine oxidase inhibitors such as phenelzine, tricyclic (Ex. amitriptyline) or selective serotonin reuptake inhibitors (SSRIs) antidepressants (Ex. escitalopram, fluoxetine), st. john’s wort (used to manage depression)
• disopyramide, quinidine, amiodarone and propafenone (used to manage irregular heartbeat)
• ketoconazole, itraconazole (used to manage fungal infections)
• ritonavir, indinavir, nelfinavir (manages HIV infection)
• rifampicin, erythromycin, clarithromycin (manages bacterial infection)
• dantrolene infusion (used for severe body temperature abnormalities)
• tacrolimus, sirolimus, temsirolimus, cyclosporine and everolimus (used to alter the way your immune system works to manage organ rejection after transplant)                                                                                   
• simvastatin (used to lower cholesterol)
• cimetidine (used to manage stomach ulcers)
• barbiturates such as phenobarbital (manages epilepsy)
• phenothiazines such as compazine (used to manage mental illness)
• lidocaine, cyclopropane or trichloroethylene (used as anesthetics)
• aldesleukin (used to manage some cancers)
• alprostadil (manages erectile dysfunction)
• temazepam, nitrazepam, diazepam (used to manage insomnia)
• indomethacin or celecoxib (manages pain)
• contraceptive pill or hormone replacement therapy (Ex. oestrogens) (used to manage pregnancy)
• hydrocortisone, prednisolone (used to manage inflammatory conditions)
• beta-blocker eye drops (Ex. timolol) (used to manage glaucoma)
• medicines used to manage diabetes such as metformin, insulin
• moxisylyte (used in raynaud’s syndrome)
• mefloquine (manages malaria)
• tropisetron (used to manage nausea and vomiting)
• aminophylline, theophylline (used to manage asthma)
• ergotamine (used to migraine headache)
• digoxin (used to manage heart conditions)
• hydroxychloroquine (used to manage rheumatoid arthritis)
• diphenhydramine (used to manage allergy)
• adrenaline (epinephrine) or noradrenaline (norepinephrine) (used in anaphylactic shock)

B. Drug - Food interaction:

Avoid consumption of grapefruit juice and grapefruit while taking PROLOMET AM 50MG TABLET, this is because grapefruit and grapefruit juice can lead to an unpredictable increase in the blood pressure lowering effect of PROLOMET AM 50MG TABLET.

Overdosage:

If you or anyone else accidentally take too much of PROLOMET AM 50MG TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of PROLOMET AM 50MG TABLET are low blood pressure (fatigue and dizziness), slow pulse, heart conduction problems, shortness of breath, unconsciousness, coma, cardiac arrest, nausea and vomiting, blue colouring of the skin, low blood sugar levels and high levels of potassium in the blood.

SYNOPSIS

MORE INFORMATION

• Keep PROLOMET AM 50MG TABLET out of reach of children
• Store PROLOMET AM 50MG TABLET at room temperature