INTRODUCTION ABOUT PROLET 25 TABLET

PROLET 25 TABLET contains Primidone which belongs to the group of medicines called Antiepileptics. It is used in the management of epilepsy, seizures (fits) and involuntary shaking movements (essential tremors).

Epilepsy is the disturbed nerve cell activity in the brain, causing seizures or periods of unusual behaviour, sensations and sometimes loss of consciousness. Your doctor may advise you to take Vitamin D supplementation (in case of long-term management).

PROLET 25 TABLET is not recommended for use in patients having porphyria. PROLET 25 TABLET should be used with caution in patients having lung, liver, kidney and problems. PROLET 25 TABLET should be used with caution during pregnancy only if clearly necessary and it is not recommended in breastfeeding woman.

Your doctor will prescribe the right dose of PROLET 25 TABLET for your child depending on their age, body weight and health condition. PROLET 25 TABLET should be used with caution in elderly patients.

PROLET 25 TABLET might make you have thoughts of killing or harming yourself. Contact your doctor immediately if you feel such symptoms. The most common side effects of taking PROLET 25 TABLET are lack of energy, visual disturbances, rolling eyes, disorders in coordination, nausea, etc. Consult your doctor for advice if any of these worsen or doesn’t improve.

USES OF PROLET 25 TABLET

Manage:

• Epilepsy
• Seizures (fits)
• Involuntary shaking movements (essential tremors)

HOW PROLET 25 TABLET WORKS

PROLET 25 TABLET reduces the seizure or fits by enhancing the inhibitory action of GABA which is a neurotransmitter (nerve chemical) that reduces the excitability and abnormal activity of the nerve cells in brain.

DIRECTIONS FOR USE

Take PROLET 25 TABLET as advised by your physician. Swallow with a glass of water and do not crush or chew it. Your doctor will decide the correct dose and duration of PROLET 25 TABLET for you depending upon your age, body weight and health condition. Do not stop taking PROLET 25 TABLET unless your doctor advises you to stop.

SIDE EFFECTS OF PROLET 25 TABLET

HOW TO MANAGE SIDE EFFECTS

Vomiting:

Drink clear or ice-cold drinks. eat light, bland foods and avoid fried, oily or sweet foods. If symptom persists, contact your doctor.

Nausea:

Take PROLET 25 TABLET with or just after meals. Stick to simple meals. Avoid eating rich or spicy food. If symptom persists, contact your doctor.

Headache:

Apply hot or cold-water bag on your head. Take enough rest in a quiet environment and don’t involve yourself in any exertional activities. apply pain relieving balm in the forehead. If symptom persists, contact your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before taking PROLET 25 TABLET, inform your doctor if you are taking any of the following medicines:

• other medicines used to manage epilepsy and other types of fiits (Ex. phenytoin, valproic acid, felbamate, perampanel, carbamazepine, oxcarbazepine, lamotrigine, tiagabine, stiripentol, zonisamide)
• medicines used to manage blood clots (Ex. acenocoumarol, phenindione, fluindione, warfarin, apixaban, rivaroxaban, dabigatran or ticagrelor)
• medicines used to induce sleep (Ex. phenobarbital, alprazolam)
• medicines used to manage severe pain (Ex. morphine, methadone, oxycodone, fentanyl)
• medicines used to manage infections (Ex. metronidazole, telithromycine, doxycycline)
• medicines used for asthma (Ex. theophylline, montelukast)
• hormonal medicines used to manage pregnancy (Ex. oral contraceptive pill, progestatives, estroprogestatives, ulipristal)
• levothyroxine (used to maintain thyroid hormone levels)
• medicines used to manage heart conditions or high blood pressure (Ex. quinidine, amlodipine, dronedarone, bosentan, ivabradine, nimodipine, macitentan, ranolazine, propafenone, propranolol, atenolol)
• medicines used to manage autoimmune disorders and transplant rejection (Ex. cyclosporine, sirolimus, tacrolimus, everolimus)
• medicines used to manage depression or mental illness (Ex. tricyclic antidepressants, lurasidone, lamotrigine, quetiapine, mianserin, sertraline, St. John’s wort)
• medicines used for inflammatory and autoimmune conditions (Ex. prednisolone, mometasone)
• medicines used in cancer management (Ex. etoposide, cyclophosphamide, abiraterone, eribuline, axitinib, ifosfamide, crizotinib, bosutinib, dabrafenib, erlotinib, dasatinib, gefitinib, imatinib, nilotinib, lapatinib, pazopanib, sorafenib,lapatinib, sunitinib, regorafenib, vemurafenib, vandetanib, vismodegib, ceritinib, cabozantinib, ibrutinib, ponatinib, olaparib, carbazitaxel, procarbazine, docetaxel, irinotecan)
• medicines used to manage tuberculosis (Ex. delamanid, bedaquiline)
• quinine (used to manage malaria)
• medicines used for viral infections like HIV infection or hepatitis c (Ex. boceprevir, daclatasvir, cobicistat, dasabuvir, lopinavir, dolutegravir, maraviroc, telaprevir ombitasvir, paritaprevir, nelfinavir, rilpivirine, simeprevir, nelfinavir, sofosbuvir)
• medicines used to manage fungal infections (Ex. voriconazole, itraconazole, albendazole, posaconazole)
• vitamin B9 (used to manage folate deficiency)
• deferasirox (used to reduce excessive iron deposition)
• ivacaftor (used to manage cystic fibrosis)
• medicines used for parasitic infections (Ex. albendazole, praziquantel)

Overdosage:

If you or anyone else accidentally take too much of PROLET 25 TABLET, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep PROLET 25 TABLET out of reach of children
• Store PROLET 25 TABLET below 25°C