INTRODUCTION ABOUT PLETOZ 100MG TABLET

PLETOZ 100MG TABLET contains Cilostazol which belongs to the group of medicines called Phosphodiesterase type 3 inhibitors. It is used in the management of intermittent claudication, which is defined as the cramp-like pain in the legs while walking caused by insufficient blood supply in the legs. Symptoms include pain, ache, discomfort or fatigue in muscles every time, when those muscles are used (usually the calves, thighs, buttocks, hips or feet).

Along with this management your doctor might advise you to make lifestyle modifications like increasing regular exercise and stop smoking. Prior to the management, your doctor may want you to take ankle-brachial index test to understand your existing condition.

PLETOZ 100MG TABLET is not recommended for use in patients having severe heart problems (such as heart failure, heart attack), uncontrolled blood pressure, kidney or liver disease, active stomach ulcer and stroke.

Do not drink large amounts of grapefruit juice while taking PLETOZ 100MG TABLET as it may reduce the effect of this medicine. PLETOZ 100MG TABLET is not recommended for use among pregnant or breastfeeding women, therefore consult your doctor before taking it. This medicine is not recommended for use in children and adolescents.

The most common side effects of taking PLETOZ 100MG TABLET are headache, abnormal stools, diarrhea, abdominal discomfort, dizziness, nausea and loss of appetite.  Consult your doctor if any of the side effects worsen over the time.

USES OF PLETOZ 100MG TABLET

• Manage intermittent claudication

HOW PLETOZ 100MG TABLET WORKS

PLETOZ 100MG TABLET acts by inhibiting the activity of certain enzymes (phosphodiesterase) which helps in the increase in the level of cAMP (cellular messengers to initiate certain actions) in platelets and blood vessels. The cAMP helps in widening of some blood vessels and reducing the clotting activity of platelets inside the blood vessels. Hence increasing the blood circulation to the legs making it easier and less painful to walk.

DIRECTIONS FOR USE

Take PLETOZ 100MG TABLET as advised by your physician. Swallow PLETOZ 100MG TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF PLETOZ 100MG TABLET

HOW TO MANAGE SIDE EFFECTS

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking PLETOZ 100MG TABLET, inform your doctor if you are taking any of the following medicines:

• acetylsalicylic acid (aspirin) (used to manage painful inflammatory condition of muscle or joints)
• anticoagulant medicines (Ex. heparin, warfarin, clopidogrel, dabigatran, rivaroxaban, apixaban) (used to manage or manage blood clots)
• certain antibiotics Ex. erythromycin, clarithromycin or rifampicin (used to manage bacterial infections)
• ketoconazole (used to manage fungal infections)
• omeprazole (used to manage acidity in the stomach)
• diltiazem (used to manage high blood pressure or chest pain)
• cisapride (used to manage stomach disorders)
• medicines used to manage high cholesterol in the blood (Ex. lovastatin, simvastatin)
• halofantrine (used to manage malaria)
• protease inhibitors such as atazanavir, darunavir (used to manage HIV infection)
• pimozide (used to manage mental illnesses)
• ergot derivatives Ex. ergotamine, dihydroergotamine (used to manage or manage migraine headaches)
• st. john’s wort (herbal remedy), carbamazepine or phenytoin (used to manage convulsions)
• diuretics Ex. hydrochlorothiazide, furosemide (used to manage fluid retention)
• calcium channel blockers such as verapamil, amlodipine, angiotensin-converting-enzyme inhibitors such as captopril, lisinopril, angiotensin II receptor blockers such as valsartan, candesartan and beta blockers such as labetalol, carvedilol (used to manage high blood pressure)

B. Drug-Food interactions:

Do not drink large amounts of grapefruit juice while taking PLETOZ 100MG TABLET as it may reduce the effect of this medicine and do not take together with meals as it may affects its absorption and increase the risk of side effects.

Overdosage:

If you or anyone else accidentally take too much of PLETOZ 100MG TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of PLETOZ 100MG TABLET includes severe headache, diarrhea, increase in heart rate and irregularities of the heartbeat.

SYNOPSIS

MORE INFORMATION

• Keep PLETOZ 100MG TABLET out of reach of children
• Store PLETOZ 100MG TABLET at room temperature