INTRODUCTION ABOUT PEXEP PLUS 12.5/0.5MG CAPSULE

PEXEP PLUS 12.5/0.5MG CAPSULE is a combination of Clonazepam and Paroxetine which belongs to the group of medicines called Anticonvulsants and Antidepressants respectively. It is used to manage depression and anxiety.

It can also be used in the management of fits (epilepsy), panic attacks, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (anxiety caused due to any traumatic event) and in certain types of phobias (fears).

Take PEXEP PLUS 12.5/0.5MG CAPSULE preferably with or after meals or as directed by your physician. Do not stop taking this medicine abruptly without consulting your doctor as it may cause certain unpleasant withdrawal symptoms. Talk to your doctor about all the medicines that you take to manage your current illnesses.

Before taking PEXEP PLUS 12.5/0.5MG CAPSULE, inform your doctor if you have any problems in your liver, kidney or heart. You must also inform your doctor if you have diabetes, glaucoma, breathing problems, bleeding disorders, mania, previous history of drug abuse, alcohol abuse or suicide as a precaution.

Do not take PEXEP PLUS 12.5/0.5MG CAPSULE without consulting your doctor if you are pregnant or breastfeeding. The most common side effects of taking PEXEP PLUS 12.5/0.5MG CAPSULE are headache, dizziness, tiredness, sleepiness, tremor, nausea, constipation, diarrhea, dry mouth, increased sweating, lack of sleep, high blood cholesterol levels, erectile dysfunction and weight gain. Consult your doctor if any of these side effect worsens.

You must also inform your doctor immediately if you experience worsening of depression along with suicidal thoughts or having severe muscle stiffness, shakiness, fever and/or chest pain as a precaution.

USES OF PEXEP PLUS 12.5/0.5MG CAPSULE

It is used to manage:

• Depression
• Anxiety
• Fits (epilepsy)
• Obsessive-compulsive disorder
• Post-traumatic stress disorder
• Panic attacks or phobias (fears)
• Obsessive-compulsive disorder

HOW PEXEP PLUS 12.5/0.5MG CAPSULE WORKS

PEXEP PLUS 12.5/0.5MG CAPSULE contains two medicines namely clonazepam and paroxetine. Clonazepam is an anticonvulsant. It suppresses the abnormal electrical activity within the brain and induces calmness.

Paroxetine is an antidepressant medicine. It works by regulating the release and uptake of certain chemical messengers (dopamine and serotonin) within the brain that affects thoughts, emotions, body movements and behaviour. As a result, it manages seizures, improves your ability to think, controls your emotions and stabilizes your mental health.

DIRECTIONS FOR USE

Take PEXEP PLUS 12.5/0.5MG CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. It must be taken with or after meals.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease conditions.

Do not stop taking PEXEP PLUS 12.5/0.5MG CAPSULE without consulting your doctor, even if you feel better during the mid-way of therapy as it could lead to withdrawal symptoms (such as tremors, sleep disturbances, headaches, muscle pain, extreme anxiety, tension, restlessness, confusion, irritability and fits).

SIDE EFFECTS OF PEXEP PLUS 12.5/0.5MG CAPSULE

HOW TO MANAGE SIDE EFFECTS

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before taking PEXEP PLUS 12.5/0.5MG CAPSULE, inform your doctor if you are taking any of the following medicine such as:

• medicine used to manage depression like monoamine oxidase inhibitors (Ex. tranylcypromine, moclobemide iproniazid, nialamide, isocarboxazid, toloxatone), fluvoxamine, lithium, selegiline, amitriptyline, imipramine, bupropion, St. John’s wort
• linezolid (a medicine used to manage bacterial infection)
• methylene blue (a medicine used to manage high methaemoglobin in blood)
• medicines used to manage psychiatric disorders (such as pimozide, haloperidol, risperidone, thioridazine, chlorpromazine, clozapine)
• medicines used to manage epilepsy (such as carbamazepine, phenytoin, phenobarbital, sodium valproate, primidone)
• medicines used for blood thinning (such as heparin, warfarin)
• medicines used for pain relief (such as aspirin, celecoxib, tramadol, ibuprofen, diclofenac)
• tamoxifen (a medicine used to manage cancer)
• medicines used to reduce anxiety and to induce sleep (such as alprazolam, midazolam, clonazepam, nitrazepam)
• general anaesthetic (used to create of loss of consciousness before surgery) such as methoxyflurane and trichloroethylene
• muscle relaxants (used for muscle relaxation prior to surgeries) such as tubocurarine
• cimetidine (a medicine used for managing stomach ulcers)
• rifampicin (a medicine used to manage tuberculosis)
• tryptophan (a medicine used to manage mental illness)
• medicines used to manage migraine headache (such as sumatriptan)
• opioid analgesic medications (such as buprenorphine, morphine, codeine or propoxyphene, pethidine, fentanyl etc.)
• pravastatin (a medicine used to control blood cholesterol levels)
• medicines used to manage viral infections (such as fosamprenavir/ritonavir)
• procyclidine (a medicine used to reduce muscle contractions and body secretions)

B. Drug-Food interactions:

PEXEP PLUS 12.5/0.5MG CAPSULE should be taken with or after meals.

Overdosage:

If you or anyone else accidentally took more PEXEP PLUS 12.5/0.5MG CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include drowsiness, joint pain, rapid eye movements, low blood pressure and breathing difficulties.

SYNOPSIS

MORE INFORMATION

• Keep PEXEP PLUS 12.5/0.5MG CAPSULE out of reach of children
• Store PEXEP PLUS 12.5/0.5MG CAPSULE at room temperature