INTRODUCTION ABOUT PANTOTAB DSR CAPSULE

PANTOTAB DSR CAPSULE is used to manage peptic ulcers, gastroesophageal reflux disease (GERD) and reflux esophagitis. It is a combination of Domperidone and Pantoprazole which belongs to the group of medicines called Prokinetic Drugs and Proton pump inhibitors respectively. PANTOTAB DSR CAPSULE acts by reducing the production of gastric acid. It also speeds up the movement of food from the stomach to the intestines, thereby reducing the signs of nausea, vomiting and acid reflux. Due to these actions, it can also reduce the unpleasant signs of GI tract such as nausea, vomiting, indigestion, burping, bloating, acidity or heartburn.

It should be taken at least 15-30 minutes before meals. During management with PANTOTAB DSR CAPSULE your doctor will closely monitor your kidney functions, liver functions and blood magnesium levels to avoid the risk of unwanted side effects. Before taking PANTOTAB DSR CAPSULE inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any blockage or tears in the gut or have weak bones.

PANTOTAB DSR CAPSULE is not recommended for use in patients bleeding from the gut. Consult your doctor before taking PANTOTAB DSR CAPSULE if you are pregnant or breastfeeding. The most common side effects are dryness of mouth, constipation and flatulence. Consult your doctor if any of these side effect bothers you. You must also inform your doctor immediately if you experience any signs of low magnesium levels in blood (such as tiredness, abnormal muscle movements, dizziness, confusion, disorientation, irregular heartbeat).

USES OF PANTOTAB DSR CAPSULE

It is used to manage:

• Peptic ulcer
• Gastrointestinal Reflux disease (GERD)
• Reflux esophagitis (inflammation of the esophagus)
• Nausea and Vomiting
• Acidity, Heartburn
• Signs of indigestion (such as burping, bloating)

HOW PANTOTAB DSR CAPSULE WORKS

PANTOTAB DSR CAPSULE contains Domperidone and Pantoprazole. Domperidone is a prokinetic medicine with anti-emetic properties which works by blocking the actions of a chemical messenger called dopamine in the gut and across the brain and spinal cord. This action stimulates the gut, reduces acid reflux and speeds up the movements of food from the stomach into the intestines. It also blocks the transmission of nerve signals between the vomiting centers and brain which reduces the onset of nausea and vomiting. Pantoprazole reduces gastric acid secretion by the blocking the actions of a protein membrane called H+K+Atpase (proton pump) present in the lining of the stomach. By reducing stomach acid production, PANTOTAB DSR CAPSULE it manages the worsening of ulcers, heals the existing ulcers and esophageal lesions and provides relief from the unpleasant symptoms of GI tract (such as acidity, bloating, burping and indigestion).

DIRECTIONS FOR USE

• Take PANTOTAB DSR CAPSULE 15-30 minutes before meals or as advised by your physician
• Swallow the medicine with a glass of water. Do not crush or chew the medicine
• Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
• Do not stop taking PANTOTAB DSR CAPSULE unless your doctor advice you to stop

SIDE EFFECTS OF PANTOTAB DSR CAPSULE

Common side effects of PANTOTAB DSR CAPSULE:

• benign polyps in the stomach
• dry mouth
• headache, dizziness, drowsiness
• diarrhea, constipation, stomach pain, flatulence

Stop taking PANTOTAB DSR CAPSULE and inform your doctor immediately if you experience any of the following side effects such as:

• severe allergic reactions (such as skin rash, itching, swelling of the lips, face or body and difficulty in breathing or swallowing)
• signs of liver problems (yellowing of the skin and eyes, dark urine and tiredness)
• severe skin reactions (such as redness, blistering, peeling of skin and bleeding in the lips, eyes, mouth, nose and genitals with fever)
• signs of kidney problem (such as lower back pain, painful urination)
• signs of low magnesium levels in blood (such as tiredness, abnormal muscle movements, dizziness, confusion, disorientation, irregular heartbeat)
• severe, persistent diarrhea
• fast or irregular heartbeat, difficulty in breathing, feeling faint
• fits
• uncontrollable body movements (including eye and tongue), twisted neck and abnormal body posture

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking PANTOTAB DSR CAPSULE inform your doctor if you are taking any of the following medicines such as:

• Aminobenzamides (Ex. cisapride, dolasetron, prucalopride, diphemanil)
• Cardiac glycosides (Ex. digoxin, apomorphine, disopyramide, hydroquinidine, quinidine, amiodarone, dofetilide, dronedarone, ibutilide, sotalol, diltiazem or verapamil)
• Anti-viral agents (Ex. atazanavir, nelfinavir, saquinavir, telaprevir)
• Antifungal (Ex. ketoconazole, itraconazole, posaconazole)
• Anti-coagulants (Ex. warfarin, phenprocoumon)
• Antipsychotics (Ex. haloperidol, pimozide, sertindole)
• Antidepressants (Ex. escitalopram or citalopram, fluvoxamine, St John’s wort)
• Antibiotics (Ex. moxifloxacin, erythromycin, levofloxacin, clarithromycin, telithromycin or amoxicillin)
• Phenanthrene class (Ex. halofantrine, lumefantrine)
• Antihistamines (Ex. mizolastine, mequitazine)
• Anti-cancer agents (Ex. toremifene, vandetanib, vincamine, erlotinib, dasatinib, nilotinib)
• Antimetabolites (Ex. methotrexate)
• Anti-arrhythmic  (Ex. bepridil)
• Opiate (narcotic) analgesics (Ex. methadone)
• Iron salts
• Immunosupressants (Ex. tacrolimus or mycophenolate mofetil)
• Anti-infective (Ex. pentamidine)
• Anti-TB agents (Ex. rifampicin)

Overdosage:

If you or anyone else accidentally took more PANTOTAB DSR CAPSULE, contact your doctor immediately or go to a hospital straight away. Symptoms of overdosage might include sleepiness, confusion, uncontrollable body movements (including eye and tongue), twisted neck and abnormal body posture.

SYNOPSIS

MORE INFORMATION

Disease description:

Peptic Ulcer: A peptic ulcer is a sore in the lining of the stomach or the first part of the small intestine. Symptoms include burning pain in the stomach that starts between meals or at night, nausea and vomiting, bloating or belching.

Gastrointestinal Reflux disease (GERD): Gastroesophageal reflux disease (GERD) is a common condition in which the stomach contents move up into the esophagus. Reflux becomes a disease when it causes frequent or severe symptoms or injury. Reflux may damage the esophagus, pharynx or respiratory tract. The main symptom of GERD is heartburn, often described as a fiery feeling in one's chest, and regurgitating sour or bitter liquid to the throat or mouth.

Reflux esophagitis: Reflux esophagitis is an esophageal mucosal injury that occurs secondary to retrograde flux of gastric contents into the esophagus.