INTRODUCTION ABOUT PANTOCID L CAPSULE

PANTOCID L CAPSULE is a combination of Levosulpiride and Pantoprazole which belongs to the group of medicines called Dopamine D2 antagonists and Proton-pump inhibitors respectively. PANTOCID L CAPSULE is indicated for the short-term management of gastro-esophageal reflux disease (GERD) among patients who do not respond adequately to proton-pump inhibitors (Ex. pantoprazole, omeprazole, rabeprazole) alone.

GERD is a chronic digestive disease in which the stomach acid frequently flows into the esophagus leading to irritation and inflammation of lining of food pipe. Symptoms include heartburn, chest pain, nausea, sensation of lump in throat and stomach discomfort.

PANTOCID L CAPSULE can also be used to manage peptic ulcer (painful sores in the gut) caused by H. pylori infection or NSAIDs use and Zollinger-Ellison syndrome (tumors in pancreas causing the stomach to secrete more acid).

Take PANTOCID L CAPSULE preferably one hour before meals. Avoid consumption of alcohol while taking PANTOCID L CAPSULE as it could potentiate the CNS depressive side effects.

Patients receiving long-term management with PANTOCID L CAPSULE should be kept on regular surveillance to rule out the risk of hypomagnesaemia (decreased magnesium levels in blood) and bone fracture, predominantly in the elderly patients and in patients with other recognized risk factors like osteoporosis. 

Before taking PANTOCID L CAPSULE inform your doctor if you have any liver, kidney or heart problems. PANTOCID L CAPSULE is generally not recommended for use in pregnant or breastfeeding women and in children or adolescents (below 18 years of age).

PANTOCID L CAPSULE should be used with caution in elderly patients (aged 65 years or above) due to increased risk of postural hypotension, sedation and extrapyramidal effects (such as involuntary muscle movements, restless, muscle stiffness).

The most common side effects of taking PANTOCID L CAPSULE are nausea, vomiting, headache, dizziness, polyps in the stomach gut and flatulence. Consult your doctor if any of the side effects worsen during or after management with PANTOCID L CAPSULE.

USES OF PANTOCID L CAPSULE

• To manage gastro-esophageal reflux disease (GERD) for short-term among patients who do not respond adequately to proton-pump inhibitors (Ex. pantoprazole, omeprazole, rabeprazole) alone
• To manage peptic ulcer and Zollinger-Ellison syndrome

HOW PANTOCID L CAPSULE WORKS

PANTOCID L CAPSULE reduces stomach ulcers and acid reflux, where pantoprazole acts by inhibiting the secretions of stomach acid by blocking the proton pump (H+ K+ ATPase) at the secretory surface of gastric parietal cells and levosulpiride acts by facilitating gastric emptying and bowel movements by blocking the dopamine D2 receptors in the gut, thus reducing acid reflux and healing of stomach ulcers and esophageal lesions.

DIRECTIONS FOR USE

Take PANTOCID L CAPSULE as advised by your physician. Swallow PANTOCID L CAPSULE with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of PANTOCID L CAPSULE for you depending upon your age, body weight and disease condition. Do not stop taking PANTOCID L CAPSULE without informing your doctor.

SIDE EFFECTS OF PANTOCID L CAPSULE

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Stick to simple meals while taking PANTOCID L CAPSULE. Avoid eating oily, fried or spicy foods. Eat meals slowly and smaller and avoid doing activities immediately after eating. Consult your doctor if the symptom did not improve.  

Diarrhea:

Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for managing diarrhea. Consult your doctor if the symptom did not improve.

Headache:  

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.

Constipation: 

Eat fiber rich foods such as fresh fruits, vegetables, cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-manage on your own and consult your doctor if the symptom did not improve on its own.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking PANTOCID L CAPSULE inform to your doctor, if you are taking any of these medicines:

• medicines used to manage fungal infections (such as ketoconazole, itraconazole or posaconazole, amphotericin B)
• erlotinib (used to manage certain types of cancer)
• warfarin and phenprocoumon (used to manage or manage thrombotic events and heart problems)
• medicines used to manage HIV infection (such as atazanavir)
• methotrexate (a medicine used to manage rheumatoid arthritis, psoriasis or cancer)
• rifampicin (used to manage tuberculosis)
• erythromycin and ampicillin esters (used to manage bacterial infections) Ex. hetacillin and pivampicillin
• iron salts (used to manage anemia) Ex. ferrous sulphate, ferrous fumarate
• medicine that can neutralize stomach acid such as antacids (Ex. aluminium- and magnesium-hydroxide) or sucralfate
• anticholinergics (used to relax or reduce the movements of smooth muscles and suppresses body secretions (Ex. atropine, hyoscine)
• analgesics (used to relieve pain) such as opioids (Ex. methadone) or non-opioids (Ex. naproxen, ibuprofen)
• sedatives and hypnotics, tranquilizers (used to reduce anxiety and to induce sleep) Ex. alprazolam, chlordiazepoxide, diazepam
• medicines used to manage depression (Ex. rasagiline, selegiline, phenelzine, haloperidol, imipramine, lithium, fluvoxamine and herbal medicine (St. John’s wort))
• medicines used to manage abnormal heart rate (Ex. digitalis, quinine, quinidine, disopyramide, amiodarone, sotalol, flecainide, procainamide)
• medicines used to manage high blood pressure or other heart problems such as beta-blockers (Ex. propranolol, atenolol) or calcium channel blockers (Ex. verapamil, diltiazem)
• antipsychotics (used to manage mental illness) Ex. risperidone, paliperidone, amisulpiride, olanzapine, thioridazine
• non-sedating antihistamines (used to manage allergic symptoms) Ex. fexofenadine, levocetirizine, loratadine
• antimalarials (used to manage malaria) Ex. quinine, primaquine, halofantrine
• cisapride (used to manage heartburn and acid reflux)
• diuretics (used to reduce blood pressure by increasing urine output) Ex. spironolactone, chlorothiazide, acetazolamide
• corticosteroids (used to manage allergy, pain or inflammation) Ex. dexamethasone, prednisolone
• stimulant laxatives (used to manage constipation) Ex. bisacodyl
• pimozide (used to reduce uncontrollable muscle movements)
• pentamidine (used to manage lung infection)

Overdosage:

If you or anyone else accidentally take too much of PANTOCID L CAPSULE, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of PANTOCID L CAPSULE might include extrapyramidal reactions (such as rigidity, tremor, drooling etc.) or sleep disturbances.

SYNOPSIS

MORE INFORMATION

• Keep PANTOCID L CAPSULE out of reach of children
• Store PANTOCID L CAPSULE at room temperature