INTRODUCTION ABOUT OXRAMET G XR 10/1/1000 TABLET

OXRAMET G XR 10/1/1000 TABLET is a combination of Dapagliflozin, Glimepiride, and Metformin, which belongs to the group of medicines called Antidiabetic agents. It is used as an adjunct to diet and exercise to improve glycemic control among patients with type II diabetes mellitus when management with single agents does not result in adequate response.

Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused by inadequate production of a hormone called insulin (produced by the pancreas to metabolize glucose) in the body or by inadequate sensitivity of body cells to the actions of insulin.

Before taking OXRAMET G XR 10/1/1000 TABLET, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have any eye problems, hormonal imbalance, alcoholism, or if you are malnourished or starved on an irregular diet as a precaution.

OXRAMET G XR 10/1/1000 TABLET is strictly not recommended for use in patients with type I diabetes mellitus, bladder cancer, severe heart failure or lactic acidosis, severe low blood pressure, or severe dehydration. It is also not suitable for use in pregnant or breastfeeding women.

Along with the management, follow the diet and lifestyle changes advised by your doctor to achieve better results. Avoid smoking and consumption of alcohol while taking OXRAMET G XR 10/1/1000 TABLET, as it may aggravate your existing condition. During therapy with OXRAMET G XR 10/1/1000 TABLET, your doctor might regularly monitor your blood sugar levels and kidney functions to avoid the risk of unwanted side effects.

The most common side effects of taking OXRAMET G XR 10/1/1000 TABLET are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness, genital infections, back pain, and passing more urine. Consult your doctor if any of these side effects worsen.

USES OF OXRAMET G XR 10/1/1000 TABLET

• It is used as an adjunct to diet and exercise to improve glycemic control among patients with type II diabetes mellitus.

HOW OXRAMET G XR 10/1/1000 TABLET WORKS

OXRAMET G XR 10/1/1000 TABLET contains three medicines, namely, metformin, glimepiride, and dapagliflozin. Metformin and glimepiride stimulate the pancreas to secrete more insulin (a hormone involved in glucose metabolism). They also make our body more sensitive to insulin, which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels. Additionally, metformin can also reduce the glucose produced by the liver and reduce its absorption in the body.

Dapagliflozin is an SGLT-2 inhibitor. It works by blocking the action of a protein called SGLT-2 in the kidneys. This action manages the reabsorption of glucose and sodium ions in the kidneys. As a result, it excretes excess glucose from the body in the form urine.

DIRECTIONS FOR USE

Take OXRAMET G XR 10/1/1000 TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.

Do not stop taking OXRAMET G XR 10/1/1000 TABLET unless your doctor advises you to stop.

SIDE EFFECTS OF OXRAMET G XR 10/1/1000 TABLET

HOW TO MANAGE SIDE EFFECTS

WARNING & PRECAUTIONS

INTERACTIONS

Before taking OXRAMET G XR 10/1/1000 TABLET, inform your doctor if you are taking any of the following medicines:

• Other medicines used to regulate blood sugar levels (such as teneligliptin, rosiglitazone, insulin, and gliclazide)
• Medicines used in pain management (Ex. aspirin, ibuprofen, celecoxib, phenylbutazone, azopropazone, oxyphenbutazone, prednisolone, betamethasone)
• Medicines for managing urinary infections (amikacin, nitrofurantoin, sulfamethoxazole)
• Antibiotics (such as tetracyclines, chloramphenicol, ciprofloxacin, and clarithromycin); antifungals (fluconazole, miconazole, and isuvaconazole)
• medicines used for blood thinning (Ex. warfarin)
• Hormones (Ex. testosterone, estradiol)
• Medicines used in the management of mental illnesses (such as moclobemide, isocarboxazid, phenelzine, tranylcypromine, fluoxetine, chlorpromazine, prochlorperazine, and lithium)
• Antihyperlipidemics (Ex. fenofibrate, nicotinic acid, colesevelam)
• Antihypertensives (Ex. enalapril, lisinopril, ramipril, atenolol, propranolol, telmisartan, olmesartan, clonidine, guanethidine, reserpine, prazosin, doxazosin)
• medicines used to manage gout (Ex. allopurinol, probenecid, sulfinpyrazone)
• medicines used in the management of cancer (Ex. cyclophosphamide, ifosfamide, trofosfamide, vandetanib, crizotinib, and olaparib)
• medicines used in the management of allergic rhinitis (Ex. tritoqualine)
• Water pills (Ex. hydrochlorothiazide)
• Anti-asthmatics (Ex. salbutamol, terbutaline)
• adrenaline (a medicine used for anaphylaxis)
• Medicines used for constipation (Ex. lactulose, liquid paraffin)

Overdosage:

If you or anyone else accidentally took more OXRAMET G XR 10/1/1000 TABLET, you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat, and confusion). To manage this, consume any sugary food immediately. If the symptoms do not improve or worsen, contact your doctor immediately. Other symptoms of overdose might include vomiting, stomach pain with muscle cramps, feeling generally unwell with severe tiredness, and difficulty breathing.

SYNOPSIS

MORE INFORMATION