INTRODUCTION ABOUT OLMEZEST CH 40MG TABLET

OLMEZEST CH 40MG TABLET is a combination of Chlorthalidone and Olmesartan which belongs to the group of medicines called Thiazide diuretics and Angiotensin-II receptor antagonists respectively. OLMEZEST CH 40MG TABLET is indicated for the management of essential hypertension.

Essential hypertension (also known as primary hypertension) is a medical condition in which the force of the blood exerted against the walls of the artery remains very high and as a result, it may lead to severe damage to the walls of blood vessels supplying various important organs. It occurs without any known secondary cause and if it remains unmanageed it can lead to severe problems such as heart attack, heart or kidney failure, stroke or even blindness.

Along management with OLMEZEST CH 40MG TABLET follow lifestyle modifications (such as losing weight, quitting smoking or alcohol intake) as advised by your physician along with a healthy balanced diet and regular physical activity (such as walking or swimming).

During the course of the management with OLMEZEST CH 40MG TABLET, your doctor might regularly check your blood pressure, kidney function and electrolyte balance to avoid the risk of side effects. Avoid eating grapefruit or consuming grapefruit juice while taking OLMEZEST CH 40MG TABLET as it could potentiate the blood pressure-lowering effect of this medicine.

Before taking OLMEZEST CH 40MG TABLET, inform your doctor if you have diabetes, liver, kidney or heart disease as a precaution. OLMEZEST CH 40MG TABLET is strictly not recommended for use in pregnant or breastfeeding women as it could cause serious harm to the baby.

OLMEZEST CH 40MG TABLET is not recommended for use in children and adolescents (aged below 18 years) due to a lack of safety data. It should be used with extreme caution in elderly patients (aged 65 years or above).

The most common side effects of taking OLMEZEST CH 40MG TABLET are headache, dizziness, tiredness, nausea, stomach pain, lack of appetite and indigestion. Consult your doctor if any of the side effects worsen.

USES OF OLMEZEST CH 40MG TABLET

• Manage essential hypertension

HOW OLMEZEST CH 40MG TABLET WORKS

OLMEZEST CH 40MG TABLET effectively reduces elevated blood pressure where olmesartan acts by blocking the actions of Angiotensin – II (a substance that causes narrowing of blood vessels and increases in blood pressure) at the angiotensin type-I receptors of the vascular smooth muscle and chlorthalidone acts by increasing the urinary excretion of sodium and water by inhibiting sodium-chloride reabsorption in the kidneys, thus leading to a marked decrease in blood pressure.

DIRECTIONS FOR USE

Take OLMEZEST CH 40MG TABLET as advised by your physician. Swallow OLMEZEST CH 40MG TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF OLMEZEST CH 40MG TABLET

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Try to take OLMEZEST CH 40MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating oil-rich or spicy foods. Consult your doctor if the symptom does not improve.

Diarrhoea:

Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own to manage diarrhoea. Consult your doctor if the symptom does not improve.

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom does not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.

Constipation: 

Eat fibre-rich foods such as fresh fruits, vegetables, cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom does not improve on its own.

Stomach pain:

Rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heating pad on your stomach. Do not self-manage on your own and consult your doctor if the symptom did not improve on its own.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking OLMEZEST CH 40MG TABLET inform to your doctor, if you are taking any of these medicines:

• other medicines used to reduce high blood pressure and other heart problems such as angiotensin-converting enzyme (ACE) inhibitors (Ex. captopril, enalapril), angiotensin receptor blockers (Ex. losartan, valsartan), calcium channel blockers (Ex. nifedipine, diltiazem, verapamil), beta-blockers (Ex. atenolol, propranolol), vasodilators (Ex. nitroglycerin, bosentan), digoxin, methyldopa, guanethidine or aliskiren
• hypericum perforatum (herbal medicine), lithium (used to manage depression or other mental illness)
• non-steroidal anti-inflammatory drugs (used to manage pain or inflammation) Ex. indomethacin
• simvastatin, colesevelam and cholestyramine (used to control high blood cholesterol levels)
• antacids (used to neutralize stomach acid) Ex. aluminium hydroxide, magnesium hydroxide
• ketoconazole, itraconazole or amphotericin (used to manage fungal infections)
• protease inhibitors (used to manage HIV infection) Ex. ritonavir, indinavir, nelfinavir
• certain antibiotics (used to manage bacterial infections) Ex. rifampicin, erythromycin, clarithromycin
• dantrolene (used to manage muscle spasticity)
• immunosuppressant (used to suppress immune function and manage graft rejection) Ex. tacrolimus, sirolimus, temsirolimus, everolimus or cyclosporine
• adrenocorticotropic hormone (used to manage various endocrine disorders)
• corticosteroids (used to manage allergic or inflammatory diseases and immune reactions) such as prednisolone or betamethasone
• anticholinergics (used to reduce stomach spasms or cramps) such as atropine, biperiden or hyoscine butylbromide
• cyclophosphamide or methotrexate (used to manage certain forms of cancer)
• salbutamol or formoterol (used to manage asthma)
• amantadine (a medicine used to manage viral infections or Parkinson’s disease)
• allopurinol (a medicine used to manage gout)
• carbenoxolone (a medicine used to manage stomach ulcers)
• calcium salts or vitamin D (used as a supplement)
• medicines used to manage diabetes (Ex. insulin, chlorpropamide or glibenclamide)
• diazoxide (used to manage low blood glucose levels)
• medicines that can alter blood potassium levels such as potassium-sparing diuretics (Ex. spironolactone, acetazolamide), salt substitutes containing potassium (Ex. losartan potassium)
• heparin (used to manage or manage blood clots)

B. Drug-Food interaction:

OLMEZEST CH 40MG TABLET can be taken with or without food. Avoid consumption of grapefruit or grapefruit juice while taking OLMEZEST CH 40MG TABLET as it may cause severe decrease in blood pressure.

Overdosage:

If you or anyone else accidentally take too much of OLMEZEST CH 40MG TABLET, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of OLMEZEST CH 40MG TABLET might include dizziness, excess sleepiness, nausea, hypovolemia, low blood pressure and electrolyte disturbances associated with cardiac arrhythmias and muscle spasms.

SYNOPSIS

MORE INFORMATION

• Keep OLMEZEST CH 40MG TABLET out of reach of children
• Store OLMEZEST CH 40MG TABLET at room temperature