INTRODUCTION ABOUT OLMEZEST AM 40MG TABLET

OLMEZEST AM 40MG TABLET is used for the management of high blood pressure among patients who remain unresponsive to therapy with either olmesartan or amlodipine alone. It is a combination of Amlodipine and Olmesartan, which belongs to the group of medicines called Antihypertensive agents.

During management with OLMEZEST AM 40MG TABLET, your doctor might check your kidney function, blood pressure, and electrolyte (Ex. potassium) concentration in your blood at regular intervals to avoid the risk of unwanted side effects. Avoid consumption of grapefruit or grapefruit juice while taking the medicine, as it could lead to an unpredictable decrease in blood pressure. Before taking OLMEZEST AM 40MG TABLET, inform your doctor if you have any liver, kidney, or heart disease. It is not recommended in early pregnancy and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage.

It is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely. OLMEZEST AM 40MG TABLET is not recommended for use in children and adolescents (aged under 18 years) due to a lack of safety data. It should be taken with caution in elderly patients (aged 65 years or older). The most common side effects are headache, dizziness, tiredness, edema, sore throat, and constipation. Consult your doctor if any of the side effects worsen.

USES OF OLMEZEST AM 40MG TABLET

• It is used for the management of high blood pressure among patients who remain unresponsive to therapy with either olmesartan or amlodipine alone

HOW OLMEZEST AM 40MG TABLET WORKS

OLMEZEST AM 40MG TABLET effectively reduces elevated blood pressure, where Olmesartan acts by inhibiting the actions of angiotensin-II (a peptide hormone that causes narrowing of blood vessels and an increase in blood pressure) at the angiotensin-II receptors of the kidneys, and Amlodipine acts by blocking the influx of calcium in the blood vessels by inhibiting the voltage-gated calcium channels, thus causing vascular smooth muscle relaxation, vasodilation, and a marked decrease in blood pressure.

DIRECTIONS FOR USE

• Take OLMEZEST AM 40MG TABLET as advised by your physician
• Swallow the medicine with a glass of water. Do not crush or chew the medicine
• Your doctor will decide the correct dose and duration of OLMEZEST AM 40MG TABLET for you depending upon your age, body weight, and disease condition

SIDE EFFECTS OF OLMEZEST AM 40MG TABLET

Common Side Effects of OLMEZEST AM 40MG TABLET:

• dizziness
• headache
• tiredness
• sore throat, runny nose, cough
• diarrhea, constipation, abdominal pain, or indigestion

Stop taking OLMEZEST AM 40MG TABLET and contact your doctor immediately if you experience any of the following side effects:

• severe allergic reactions (such as skin rash with itching and swelling of the face, mouth, and/or larynx)
• signs of hypotension (such as severe dizziness or light-headedness and fainting)
• severe, persistent diarrhea with substantial weight loss
• yellowing of the whites of the eyes, dark urine, and itching of the skin

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking the medicine, inform your doctor if you are taking any of these medicines:

• Angiotensin-converting enzyme (ACE) inhibitors (Ex. enalapril, lisinopril, ramipril) or aliskiren
• Potassium-containing medicines (Ex. potassium supplements, salt substitutes containing potassium (Ex. losartan potassium)
• Diuretics (Ex. spironolactone)
• Non-steroidal anti-inflammatory drugs (Ex. ibuprofen, aspirin, diclofenac)
• Antacids (Ex. aluminium hydroxide or magnesium hydroxide)
• Bile acid sequestrants (Ex. colesevelam, simvastatin)
• Anti-viral agents (Ex. ritonavir, nelfinavir, or indinavir)
• Antifungal agents (Ex. ketoconazole or itraconazole)
• Immunosuppressants (Ex. tacrolimus, sirolimus, temsirolimus, everolimus, and cyclosporin)
• Anticoagulants (Ex. heparin)
• Anti-manic agents (Ex. Lithium)
• Calcium-channel blockers (Ex. Diltiazem, Verapamil)
• Antibiotics (Ex. Rifampicin, Erythromycin or Clarithromycin)
• St. John’s wort
• Skeletal muscle relaxants (Ex. Dantrolene)

B. Drug-Food interaction:

Avoid eating grapefruit or consuming grapefruit juice while taking OLMEZEST AM 40MG TABLET, as it could lead to an increase in the levels of amlodipine in the blood, which may lead to an unpredictable decrease in blood pressure.

Overdosage:

If you or anyone else accidentally takes too much of OLMEZEST AM 40MG TABLET, contact your doctor immediately or go to a hospital right away. Overdosage symptoms include low blood pressure, dizziness, and a fast or slow heartbeat.

SYNOPSIS