INTRODUCTION ABOUT NAXDOM 500 TABLET

NAXDOM 500 TABLET is a combination of Domperidone and Naproxen, which belong to the groups of medicines called antiemetics and NSAIDs (non-steroidal anti-inflammatory drugs), respectively. It is used to manage the symptoms of migraine, menstrual migraine, and chronic daily headaches associated with nausea and vomiting.

A migraine is a recurring headache that often involves one side of the head and causes severe pain that is pulsating or throbbing and is accompanied by nausea, weakness, and sensitivity to sound and light.

NAXDOM 500 TABLET is not recommended in patients with severe liver, kidney, or heart problems, stomach ulcers, bleeding in the stomach or intestine, intestinal tears, or pituitary gland tumours. NAXDOM 500 TABLET should be taken with caution in patients with lung disease, diabetes, high cholesterol, systemic lupus erythematosus, a blood clotting disorder, a history of gastrointestinal diseases, and a habit of drinking or smoking.

NAXDOM 500 TABLET is not recommended for use during pregnancy, while breastfeeding, or in children less than 5 years old. It should be used with caution in elderly patients (those over the age of 60). The common side effect of taking NAXDOM 500 TABLET may include dry mouth. Consult your doctor immediately if your symptoms get worse or persist.

USES OF NAXDOM 500 TABLET

Manage symptoms of

• migraine
• menstrual migraine
• chronic daily headache

HOW NAXDOM 500 TABLET WORKS

NAXDOM 500 TABLET effectively manages migraine, which is commonly associated with nausea and vomiting, by blocking the centres in the brain and stomach that regulate nausea and vomiting. It also increases the contractions and movements in the stomach. NAXDOM 500 TABLET stops the pain pathways and reduces the release of substances (prostaglandins) that cause inflammation, thus decreasing pain and inflammation.

DIRECTIONS FOR USE

Take NAXDOM 500 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of NAXDOM 500 TABLET for you depending on your age, body weight and disease condition.

SIDE EFFECTS OF NAXDOM 500 TABLET

HOW TO MANAGE SIDE EFFECTS

Headache:

Try to rest and relax. Do not involve yourself in exertive activities. Apply a pain-relieving balm on your forehead.

Diarrhoea:

Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.

Drowsiness:

Take adequate sleep. Do not involve in rigorous activities. Do not interfere with your sleep cycle. Talk to your doctor if the symptom doesn’t improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug–Drug Interactions:

Inform your physician if you are taking any of the following drugs before taking NAXDOM 500 TABLET:

• medicines used to manage heart problems, high blood pressure (Ex. amiodarone, dronedarone, quinidine, disopyramide, captopril, ramipril, losartan, candesartan, dofetilide, sotalol, diltiazem, verapamil)
• medicines used in the management of psychoses (Ex. haloperidol, pimozide, sertindole), depression (Ex. citalopram, escitalopram), mental illness (Ex. lithium), epilepsy (Ex. phenytoin)
• medicines used to manage gastrointestinal disorders (Ex. cisapride, dolasetron, prucalopride), antacids (Ex. aluminium hydroxide gel)
• medicines used to manage bacterial infections (Ex. erythromycin, clarithromycin, ciprofloxacin, telithromycin, moxifloxacin, pentamidine)
• medicines used in the management of cancer (Ex. toremifene, methotrexate, vandetanib, vincamine)

Overdosage:

If you or anyone else accidentally takes too much NAXDOM 500 TABLET, consult your doctor immediately or visit the nearby hospital. Overdoes of NAXDOM 500 TABLET can cause headaches, nausea, vomiting, sleepiness, confusion, heartburn, fainting, diarrhoea, disorientation, stomach or intestine bleeding, unconsciousness, drowsiness, dizziness, ringing or buzzing sensation in the ears, fits and excitation, unusual eye movements, unusual tongue movements, or abnormal posture (such as a twisted neck).

SYNOPSIS

MORE INFORMATION

• Keep NAXDOM 500 TABLET out of reach from children
• Store below 25°C