INTRODUCTION ABOUT METOSARTAN 50MG TABLET

METOSARTAN 50MG TABLET is a medication used to manage hypertension (high blood pressure). By lowering blood pressure, it reduces the risk of heart attacks and strokes. It contains a combination of two medicines, metoprolol and telmisartan which works together effectively to improve heart functions.

It is recommended to take METOSARTAN 50MG TABLET with food at the same time each day to maintain consistent blood levels. Continue taking it as prescribed by your doctor, even if you feel fine, since high blood pressure often presents no symptoms. Stopping the medication abruptly can worsen your condition. Along with the medicine, staying active, maintaining a healthy diet, and managing your weight can further help control blood pressure. Always follow your doctor’s guidance while on this therapy.

Common side effects include headache, weakness, dizziness, low blood pressure, increased potassium levels, orthostatic hypotension (which may lead to fainting), breathlessness, nausea, vomiting, abdominal pain, and fatigue. It is advised to avoid potassium-rich foods or supplements while taking this medicine. Since it can cause dizziness, avoid driving or get up slowly from a seated position. Regular monitoring of blood pressure, blood sugar, kidney function, urea, and electrolyte levels may be required during treatment.

Before starting this medicine, inform your doctor if you have any kidney or liver issues. Pregnant or breastfeeding women should consult their doctor before use. Also, let your doctor know about any other medications you are taking, particularly those for blood pressure or heart conditions.

USES OF METOSARTAN 50MG TABLET

• High blood pressure (hypertension)

Benefits of METOSARTAN 50MG TABLET in Hypertension:

• Effective Blood Pressure Control: Helps lower high blood pressure, reducing the risk of heart attacks, strokes, and other cardiovascular complications.
• Heart Health Support: Improves heart function and prevents further damage in patients with hypertension or heart disease.
• Improved Survival After Heart Attack: Early use enhances recovery and survival chances in patients who have suffered a heart attack.
• Protects Organs: Prevents damage to vital organs like the brain, heart, and kidneys caused by prolonged high blood pressure.
• Convenient Once-Daily Dosage: Easy-to-follow treatment schedule ensures consistent medication levels for optimal results.

HOW METOSARTAN 50MG TABLET WORKS

METOSARTAN 50MG TABLET helps in managing high blood pressure where metoprolol works by managing certain chemical messengers to bind their respective receptors in the heart and vessels, causing heart to beat slowly with less force and telmisartan blocks the effect of angiotensin II receptor (a chemical messenger that narrow down your blood vessels) that causes relaxation and widening of blood vessels resulting in lowering of blood pressure.

DIRECTIONS FOR USE

Take METOSARTAN 50MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Dosage and Administration

• The typical dose is one tablet daily, taken as prescribed by your doctor.
• The dosage may vary based on individual health conditions, age, and response to treatment. Always follow your doctor's instructions.
• Take the tablet at the same time each day to maintain consistent levels of the medication in your bloodstream.
• It can be taken with or without food, but taking it with food may help reduce side effects like nausea or dizziness.
• It should be taken regularly for long-term blood pressure control.
• Do not stop taking the medication abruptly, as it can lead to a rebound increase in blood pressure or heart rate.

Missed Dosage instructions for METOSARTAN 50MG TABLET:

• If you miss a dose take it as soon as you remember.
• If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do not take a double dose to make up for the missed one, as this may increase the risk of side effects.

Overdosage instructions for METOSARTAN 50MG TABLET:

• Symptoms of overdose include severe dizziness, excessive drop in blood pressure, low or irregular heartbeat and breathing difficulties.
• In case of an overdose, seek immediate medical attention or call a poison control center. Overdosing on this medication can lead to life-threatening complications, including heart failure or circulatory collapse.

SIDE EFFECTS OF METOSARTAN 50MG TABLET

Like all medicines, METOSARTAN 50MG TABLET may cause certain side effects, although not everybody gets them.

The most common side effects of taking METOSARTAN 50MG TABLET are:

• Tiredness
• Dizziness
• Depression
• Shortness of breath
• Slow heartbeat
• Low blood pressure
• Diarrhoea
• Itchy skin
• Rash
• Vertigo (sudden internal or external spinning sensation)

When to consult your doctor?

• Sepsis (a life-threatening severe infection occurring due to damage of whole-body immune response)
• Angioedema (rapid and serious swelling of the skin and mucosa)

HOW TO MANAGE SIDE EFFECTS

WARNING & PRECAUTIONS

SAFETY ADVICE

• Always take METOSARTAN 50MG TABLET exactly as advised by your doctor to effectively manage hypertension.
• Regularly check your blood pressure at home to ensure the medication is working effectively.
• Do not stop taking METOSARTAN 50MG TABLET abruptly, as it may cause a sudden rise in blood pressure or other complications.
• Drink plenty of fluids, especially in hot weather, to prevent dehydration, which can lower blood pressure excessively.
• Limit salt intake and follow a balanced, heart-healthy diet for optimal results. Avoid potassium-rich foods (e.g., bananas, oranges) unless advised otherwise, as Telmisartan may increase potassium levels.
• Avoid alcohol consumption while on this medication, as it can increase drowsiness and dizziness.
• Avoid Driving or Heavy Machinery: it may cause dizziness or fatigue, especially when starting the treatment. Avoid tasks requiring alertness until you know how it affects you.
• Not recommended for use during pregnancy or breastfeeding. Consult your doctor immediately if you become pregnant while taking this medication.
• Seek immediate medical attention if you accidentally take more than the prescribed dose, as it may cause severe dizziness, fainting, or a slow heartbeat.
• Start with a lower dose if prescribed for elderly patients, as they are more susceptible to side effects like hypotension and dizziness.
• Visit your doctor for regular blood tests to monitor potassium levels, kidney function, and overall response to the medication.

Drug - Drug interaction

1. Interactions with Antihypertensive Medications

Other RAAS Inhibitors (e.g., ACE inhibitors or ARBs): Co-administration can increase the risk of hyperkalemia, kidney dysfunction, or hypotension. Regular monitoring of potassium levels and renal function is recommended.

Diuretics (e.g., Furosemide, Hydrochlorothiazide): Co-administration may lead to an excessive drop in blood pressure, especially after the first dose, due to synergistic antihypertensive effects.

2. Interactions with Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Drugs like Ibuprofen, Naproxen, or Aspirin can reduce the antihypertensive effect of this tablet

Long-term use of NSAIDs with Telmisartan can impair renal function and increase the risk of renal failure, particularly in elderly patients or those with existing kidney disease.

3. Interactions with Antidiabetic Medications

Telmisartan may enhance the blood sugar-lowering effects of insulin or oral antidiabetic drugs, increasing the risk of hypoglycemia.

Metoprolol can mask symptoms of hypoglycemia, such as tachycardia, which may delay treatment in diabetic patients.

4. Interactions with Drugs Affecting Potassium Levels

Potassium-Sparing Diuretics (e.g., Spironolactone, Amiloride) or Potassium Supplements:
Telmisartan may increase potassium levels, leading to hyperkalemia, a condition characterized by muscle weakness, fatigue, and irregular heart rhythms.

5. Interactions with Calcium Channel Blockers

Amlodipine or other calcium channel blockers combined with Metoprolol may result in an additive effect, leading to severe bradycardia, hypotension, or dizziness.

6. Interactions with Antiarrhythmic Drugs

Amiodarone or Digoxin: Metoprolol’s beta-blocking properties may increase the risk of severe bradycardia or conduction disturbances. Digoxin levels should be monitored, as they may rise due to Telmisartan.

7. Interactions with CNS Depressants

Sedatives, antidepressants (e.g., SSRIs), or antipsychotics: Metoprolol may amplify the sedative effects of these drugs, causing excessive drowsiness, fatigue, or dizziness.

8. Interactions with Lipid-Lowering Medications

Statins (e.g., Atorvastatin, Rosuvastatin): Metoprolol metabolism may be affected, increasing the risk of muscle pain or rhabdomyolysis.

SYNOPSIS

MORE INFORMATION

Onset of action: The combination of Telmisartan and Metoprolol usually begins to show effects within 1–3 hours after administration, targeting both high blood pressure and heart rate effectively.

Duration of action: The combined action lasts for a full 24 hours, ensuring consistent blood pressure and heart rate management with once-daily dosing.