INTRODUCTION ABOUT MAXDULIN 75/20 CAPSULE

MAXDULIN 75/20 CAPSULE is used in the management of nerve pain (or neuropathy) caused by conditions like diabetes, spinal cord injury, or fibromyalgia. This medication helps reduce pain signals sent by damaged nerves and improves quality of life.

MAXDULIN 75/20 CAPSULE can be taken with or without food, but it’s essential to take it at the same time daily to maintain consistent levels in the body. Always follow the dosage and duration recommended by your doctor, as this medicine is a habit-forming medicine. If you miss a dose, take it as soon as you remember. Avoid stopping the medication abruptly, as it can worsen your symptoms. Ensure you complete the full course of treatment even if you feel better.

Before starting MAXDULIN 75/20 CAPSULE, inform your doctor if you have kidney or liver problems, a history of depression, mood changes, or suicidal thoughts. Let your doctor know if you are pregnant, planning to conceive, or breastfeeding.

Additionally, share details about any other medications you are taking to avoid interactions that may reduce the effectiveness of MAXDULIN 75/20 CAPSULE MAXDULIN 75/20 CAPSULE or cause side effects.

Regular follow-ups with your doctor are important to monitor your response to the medicine and manage any side effects. Avoid consuming alcohol while taking MAXDULIN 75/20 CAPSULE as it may make you feel dizzier.

Some common side effects of MAXDULIN 75/20 CAPSULE includes peripheral edema (swelling in the limbs), nausea, headache, dry mouth, tingling or numbness, constipation, reduced sex drive, blurred vision and difficulty concentrating. This medicine may cause drowsiness or dizziness, so avoid driving or operating machinery until you understand how it affects you. It may also lead to weight gain, which can be managed with a balanced diet and regular exercise.

USES OF MAXDULIN 75/20 CAPSULE

• Neuropathic pain

Benefits of MAXDULIN 75/20 CAPSULE for nerve pain:

• Relieves Nerve Pain: Controls calcium channel activity in nerve cells to block pain signals and provide effective relief from burning, tingling, or stabbing pain.
• Improves Mood and Mental Balance: Enhances levels of certain brain chemicals such as serotonin and norepinephrine to reduce stress, anxiety, and depression often linked with chronic nerve pain.
• Dual-Action Therapy: Combines Pregabalin and Duloxetine to target both physical pain and emotional well-being for comprehensive relief.
• Boosts Quality of Life: Reduces nerve pain and improves sleep, mood, and daily functionality for individuals with conditions like diabetic neuropathy or fibromyalgia.

HOW MAXDULIN 75/20 CAPSULE WORKS

MAXDULIN 75/20 CAPSULE is a powerful medication designed to manage neuropathic pain. It combines two active ingredients, Pregabalin and Duloxetine, to provide relief from nerve pain and improve mental well-being. Here's how it works:

• Pregabalin: This component reduces nerve pain by controlling calcium channels in overactive nerve cells. It prevents the transmission of pain signals, effectively reducing the burning, tingling, or stabbing sensations caused by nerve damage.
• Duloxetine: It boosts the levels of serotonin and norepinephrine, which are chemical messengers in the brain. This action helps in maintaining mental balance, reducing anxiety, and relieving stress associated with chronic pain.

Together, these ingredients offer dual-action relief, targeting both the physical pain and emotional distress caused by nerve damage. MAXDULIN 75/20 CAPSULE not only alleviates pain but also enhances mood, sleep quality, and overall quality of life.

DIRECTIONS FOR USE

• Take MAXDULIN 75/20 CAPSULE as advised by your physician.
• Swallow MAXDULIN 75/20 CAPSULE with a glass of water. Do not crush or chew the medicine.
• MAXDULIN 75/20 CAPSULE can be taken with or without food, but taking it at the same time every day ensures consistent levels of the medication in your body.

Dosage and Administration for MAXDULIN 75/20 CAPSULE:

1. Always start with the dose advised by your doctor, which may be adjusted based on your condition and response to treatment.
2. Do not alter the dosage or stop taking the medicine without consulting your doctor, as sudden discontinuation may worsen your symptoms.

Missed Dose instructions for MAXDULIN 75/20 CAPSULE:

• If you miss a dose, take it as soon as you remember.
• However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
• Do not double the dose to make up for the missed one.

Overdosage:

• Taking more than the prescribed dose can lead to serious side effects such as extreme drowsiness, confusion, or difficulty breathing.
• Symptoms of overdosage might include feeling sleepy, confused, agitated, or restless, fits, vomiting, fast heart rate or signs of serotonin syndrome (such as excitement, drowsiness, clumsiness, restlessness, feeling of being drunk, fever, sweating or rigid muscles).
• If you suspect an overdose, seek immediate medical attention or contact a poison control center.

Misuse, Abuse and Drug Dependence:

• MAXDULIN 75/20 CAPSULE contains Pregabalin, which has the potential for misuse or abuse.
• Avoid sharing this medication with others, especially individuals with a history of substance abuse or addiction.
• Use the medicine only as prescribed to minimize the risk of dependence.
• Long-term or improper use of MAXDULIN 75/20 CAPSULE may lead to physical or psychological dependence.
• To avoid dependence, your doctor may gradually reduce the dosage when stopping the medication.

SIDE EFFECTS OF MAXDULIN 75/20 CAPSULE

Like all medicines, MAXDULIN 75/20 CAPSULE may cause certain side effects, although not everybody gets them.

Some of the most common side effects of MAXDULIN 75/20 CAPSULE are:

• dizziness, drowsiness, headache
• increased appetite, weight gain
• Dry mouth, nausea, constipation
• increased mood, difficulty in concentration
• tingling or numbness, sedation, lethargy
• blurred vision, double vision
• weight gain, increased sweating
• muscle cramps, joint or back pain, pain in limbs
• sore throat
• difficulties with erection, inability to reach orgasm, decreased sexual drive, delayed ejaculation
• painful urination, frequent urination

When to Consult your doctor?

Stop taking MAXDULIN 75/20 CAPSULE and contact your doctor immediately if you experience any of the following side effects:

• suicidal thoughts and behaviour
• serious skin reaction involving reddish non-elevated, target-like, or circular patches on the trunk, often with central blisters, skin peeling, ulcers of mouth, throat, nose, genitals and eyes (Stevens-Johnson syndrome, toxic epidermal necrolysis)
• feeling restless, urge to move, increased irritation
• signs of serotonin syndrome (feeling agitated, hallucinations, confusion, loss of consciousness, fast heartbeat, feeling dizzy, increased sweating, flushing, tremors, stiff muscles, or muscle twitching, loss of coordination, nausea, vomiting, diarrhea or seizures)
• signs of allergic reactions (such as skin rash, itching, swellling of the face, lips, tongue and throat which causes difficulty in breathing or swallowing)

To know more about the safety of this medicine, refer

Pregabalin (Adverse Reactions) USFDA

Duloxetine (Adverse Reactions) USFDA

HOW TO MANAGE SIDE EFFECTS

WARNING & PRECAUTIONS

SAFETY ADVICE

Expert tips to maximize the effects of MAXDULIN 75/20 CAPSULE:

• Follow the Prescribed Dosage: Always take MAXDULIN 75/20 CAPSULE as prescribed by your healthcare provider. Do not adjust the dose or frequency without consulting your doctor to ensure optimal results and minimize side effects.
• Take Consistently at the Same Time Daily: For best results, take MAXDULIN 75/20 CAPSULE at the same time every day. This helps maintain steady levels of the medication in your body and enhances its effectiveness.
• Avoid Alcohol and Sedatives: Minimize alcohol consumption and avoid other CNS depressants (e.g., sedatives, benzodiazepines) while using MAXDULIN 75/20 CAPSULE to prevent excessive drowsiness and ensure proper treatment.
• Monitor Side Effects: Keep track of any side effects, such as dizziness or dry mouth, and report them to your doctor. Your healthcare provider may adjust the dosage or recommend additional measures to help manage these effects.
• Maintain a Healthy Lifestyle: Exercise regularly and eat a balanced diet to help reduce potential weight gain and manage constipation, both of which may be side effects of MAXDULIN 75/20 CAPSULE.
• Consult Your Doctor Before Stopping: Do not suddenly stop taking MAXDULIN 75/20 CAPSULE, as this may worsen your symptoms. Always consult your healthcare provider for a gradual reduction in dosage if discontinuation is necessary.

INTERACTIONS

A. Drug – Drug interactions:

1. Central Nervous System Depressants (e.g., benzodiazepines, opioids, sedatives):
   • Effect: Taking MAXDULIN 75/20 CAPSULE with other central nervous system depressants can enhance sedative effects, leading to increased drowsiness, dizziness, and difficulty concentrating.
2. Monoamine Oxidase Inhibitors (MAOIs) (e.g., phenelzine, tranylcypromine):
   • Effect: Combining Duloxetine with MAOIs can lead to dangerous increases in serotonin levels, a condition called serotonin syndrome, which can cause symptoms like agitation, hallucinations, fever, rapid heartbeat, and muscle rigidity.
3. Blood Pressure Medications (e.g., antihypertensives):
   • Effect: Duloxetine present in the medicine may increase blood pressure, especially when taken in high doses or in combination with certain antihypertensive drugs.
4. Alcohol:
   • Effect: Alcohol can increase the sedative effects of MAXDULIN 75/20 CAPSULE, leading to excessive drowsiness, dizziness, and impaired coordination. It may also worsen depression and anxiety symptoms.
5. Antidiabetic Medications (e.g., insulin, metformin):
   • Effect: The Duloxetine present in the medicine may lower blood sugar levels, which could interact with diabetes medications and lead to hypoglycemia (low blood sugar).

Drug-Food Interactions

1. High-Fat Meals:
   • Effect: High-fat meals can slow the absorption of MAXDULIN 75/20 CAPSULE, which may delay its effectiveness.
2. Caffeine:
   • Effect: Caffeine may increase nervousness or anxiety, counteracting some of the calming effects of Duloxetine.
3. Grapefruit Juice:
   • Effect: Grapefruit juice may interfere with the metabolism of certain medications, including Duloxetine. This could increase the drug's concentration in the body and heighten the risk of side effects.
4. Alcoholic Beverages:
   • Effect: Alcohol can enhance the side effects of MAXDULIN 75/20 CAPSULE, especially its sedative effects, leading to excessive drowsiness and impaired judgment.

SYNOPSIS

MORE INFORMATION

Is MAXDULIN 75/20 CAPSULE addictive or habit-forming?

Yes, MAXDULIN 75/20 CAPSULE has the potential to be habit-forming, particularly due to the Pregabalin component. Pregabalin can lead to physical dependence if used for a prolonged period or at higher doses than prescribed. While it is effective for managing neuropathic pain, it’s important to follow the prescribed dosage and avoid misuse.

If the medication is discontinued suddenly, it may cause withdrawal symptoms or worsen pain, so it should only be stopped under the supervision of a healthcare provider, who may recommend a gradual reduction in dosage to minimize withdrawal effects.

Always take MAXDULIN 75/20 CAPSULE exactly as prescribed, and consult your doctor if you have concerns about dependence or misuse.