INTRODUCTION ABOUT JARDIANCE 25MG TABLET

Jardiance 25mg Tablet is an FDA-approved medication used to manage Type 2 diabetes, chronic kidney disease, heart failure, risks for hospitalization and other fatal complications caused by high blood sugar levels. It belongs to a class of drugs known as SGLT-2 inhibitors, which help reduce blood sugar levels. It also aids in heart health and weight management.

Appropriate diet and exercise can help the body use its blood sugar better. Follow any advice given by your doctor regarding foot care. Prior to the management, your doctor may want you to take several blood tests to understand the existing condition. Before taking Jardiance Tablet, inform your doctor if you have any serious liver, kidney or heart problems or type I diabetes mellitus. Jardiance 25 Tablet is not recommended in pregnant or breastfeeding women.

Due to limited therapeutic experience, elderly patients (above 75 years of age) should consult the doctor before taking Jardiance 25 Tablet. The most common side effects are low blood sugar, genital infection, frequent urination, rash, itching, thirst, or constipation. Consult your doctor if any of the above side effects get worsen.

KEY COMPOSITION

Jardiance 25mg Tablet contains an active ingredient called:

• Empagliflozin (an SGLT-2 inhibitor)

USES OF JARDIANCE 25MG TABLET

• Type 2 Diabetes Mellitus along with diet, exercise and lifestyle changes
• FDA approved for reducing the risk of heart failure, chronic kidney failure and risk other complications in diabetic patients (View USFDA Approval News)
• Suitable for use in adults and in children (aged 10 years or older)
• Not suitable for use in patients with type I diabetes

Benefits of Jardiance in Type 2 Diabetes:

• Helps Lower Blood Sugar: Jardiance works by reducing the amount of glucose reabsorbed in the kidneys, effectively lowering blood sugar levels.
• Promotes Weight Loss: Although not approved for weight loss, some research studies shows that Jardiance helps promote moderate weight loss by eliminating excess glucose through urine. (Boehringer-ingelheim – Jardiance’s effects on weight loss)
• Improves Insulin Sensitivity: Regular use of Jardiance may enhance insulin sensitivity, making it easier for the body to manage blood sugar.
• Reduces Risk of Complications: Long-term use of Jardiance reduces the risk of developing diabetes-related complications such as heart disease and neuropathy.

Benefits of Jardiance in Chronic Kidney Disease:

Jardiance has proven benefits for patients with chronic kidney disease (CKD), especially in those with Type 2 Diabetes. Studies show that Jardiance helps slow down the progression of kidney damage by reducing blood sugar levels and lowering blood pressure, two key factors that contribute to kidney deterioration in diabetic patients. Additionally, it reduces the amount of protein in the urine, a sign of kidney damage.

(View NCT03594110 clinical trial)

Benefits of Jardiance for Cardiovascular Health:

• Reduces Heart Failure Risk: Jardiance significantly lowers the risk of hospitalization due to heart failure, a common complication in diabetic patients.
• Lowers Cardiovascular Mortality: Studies indicate that Jardiance can lower the risk of cardiovascular death in people with Type 2 diabetes and heart disease.
• Improves Heart Function: By reducing blood sugar and lowering blood pressure, Jardiance helps improve overall heart function and reduces the strain on the heart.
• Reduces the Risk of Stroke and Heart Attack: Jardiance has been proven to lower the risk of major cardiovascular events such as heart attacks, strokes, and heart failure.

(View Jardiance by Boehringer Ingelheim for heart failure)

HOW JARDIANCE 25MG TABLET WORKS

Jardiance 25mg Tablet, containing the active ingredient Empagliflozin works by inhibiting the SGLT2 protein in the kidneys, which promotes urine excretion of glucose, thereby reducing blood glucose levels.

For Type 2 Diabetes: Jardiance helps improve blood sugar control in adults and children aged 10 years and older when combined with diet and exercise. It works by reducing excess glucose in the bloodstream, making it easier to manage diabetes.

For Heart Failure: Jardiance has been proven to reduce the risk of cardiovascular death and hospitalization in adults with heart failure. It improves heart function by decreasing fluid retention and supporting overall cardiovascular health.

For Chronic Kidney Disease: Jardiance reduces the risk of kidney function worsening and progressing to end-stage kidney disease (ESKD). It also lowers the risk of fatal cardiovascular complications and reduces hospitalizations in adults with chronic kidney disease.

By targeting multiple pathways, Jardiance works effectively to manage blood sugar, support heart function, and protect kidney health, offering comprehensive benefits for patients with Type 2 diabetes, heart failure, and chronic kidney disease.

View – Jardiance mechanism of action

DIRECTIONS FOR USE

• Take Jardiance 25 Tablet as advised by your physician
• Swallow the medicine with a glass of water with or without food
• To achieve the best results, take it at the same time every day.

Dosage and Administration of Empagliflozin:

The usual recommended dose is 10mg or 25mg once daily, depending on your condition and response to treatment. Always follow your healthcare provider’s instructions for the correct dosage.

Missed Dosage instructions for Jardiance Tablet:

If you miss a dose of Jardiance, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for the missed one.

Overdose of empagliflozin:

In case of an overdose, seek immediate medical attention. Symptoms may include dehydration, low blood sugar (hypoglycemia), or other complications. Contact your doctor or a poison control center right away for further advice.

SIDE EFFECTS OF JARDIANCE 25MG TABLET

Like all medicines, JARDIANCE 25MG TABLET may cause certain side effects, although not everybody gets them.

Common side effects of Jardiance Tablet:

• low blood sugar levels (shaking, sweating, feeling very anxious or confused, fast heartbeat, excessive hunger, headache)
• urinary tract infection, frequent urination
• dehydration
• genital yeast infection
• itching, rash or red skin, hives
• stretching or pain when emptying the bladder

Stop taking Jardiance Tablet and consult your doctor immediately if you experience any of the following side effects:

• diabetic ketoacidosis (rapid weight loss, nausea, stomach pain, too much thirst, breathlessness, confusion, tiredness, a sweet-smelling breath, a sweet or metallic taste in your mouth or a different odour to your urine or sweat)

HOW TO MANAGE SIDE EFFECTS

Managing Vaginal Yeast Infections:

If you get vaginal infections after taking Jardiance tablet, you must inform your doctor and take necessary steps. However, here are some simple tips which you can follow along with the therapy to fasten recovery.

1. Maintain Good Hygiene: Keep the genital area clean and dry to prevent fungal overgrowth.
2. Wear Loose Clothing: Avoid tight or synthetic underwear; opt for cotton to improve ventilation.
3. Use Antifungal Creams: Over-the-counter antifungal creams or suppositories (like clotrimazole) can help relieve symptoms.
4. Avoid Scented Products: Stay away from scented soaps or feminine hygiene sprays that can irritate the area.
5. Probiotics: Incorporate probiotic-rich foods like yogurt to help maintain a healthy vaginal pH balance.

Managing Urinary Tract Infections (UTIs):

If you experience managing urinary tract infections after taking Jardiance, it is important to inform your doctor and follow the recommended course of action. In the meantime, here are some simple tips you can follow alongside your treatment to help speed up recovery.

1. Stay Hydrated: Drink plenty of water to flush out bacteria from the urinary tract.
2. Cranberry Juice: Unsweetened cranberry juice may help reduce the risk of bacteria sticking to the bladder wall.
3. Urinate Frequently: Avoid holding urine for long periods; empty your bladder completely when you go.
4. Warm Compress: Apply a warm compress to your lower abdomen to relieve discomfort.
5. Avoid Irritants: Steer clear of caffeine, alcohol, and spicy foods that can irritate the bladder.

WARNING & PRECAUTIONS

INTERACTIONS

Drug-Drug interactions:

Before taking Jardiance, inform your doctor if you are taking any of the following medicine:

• diuretics (Ex. furosemide, chlorthalidone)
• sulphonylureas (Ex. glimepiride, glyburide)

SYNOPSIS