INTRODUCTION ABOUT JANUMET 50/500MG TABLET

JANUMET 50/500MG TABLET is used to control blood sugar levels in patients with type II diabetes mellitus, along with proper diet and exercise. It is a combination of Metformin and Sitagliptin, which belongs to the group of medicines called Antidiabetic agents.

Before taking JANUMET 50/500MG TABLET, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have high blood cholesterol levels, severe systemic infections, or are severely dehydrated due to excessive vomiting or diarrhea recently. During therapy with JANUMET 50/500MG TABLET, your doctor might regularly monitor your blood sugar levels and kidney functions to avoid the risk of unwanted side effects. You may asked to make certain lifestyle changes, such as following a healthy diet, regular physical exercise, and quitting alcohol consumption, to achieve better results.

JANUMET 50/500MG TABLET is not recommended for use in patients with severe, uncontrollable diabetes. It is also not suitable for use in patients with alcoholism, shock, or problems with breathing or blood circulation. Consult your doctor before taking JANUMET 50/500MG TABLET if you are pregnant or breastfeeding. The most common side effects of taking JANUMET 50/500MG TABLET are low blood sugar levels, stomach upset, constipation, flatulence, metallic taste in the mouth, sore throat, stuffy nose, and joint pain. Consult your doctor if they bother you.

USES OF JANUMET 50/500MG TABLET

• Used to manage type II diabetes mellitus

HOW JANUMET 50/500MG TABLET WORKS

JANUMET 50/500MG TABLET is an antidiabetic medicine. It contains two medicines, namely metformin and sitagliptin. Metformin makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells utilize more of the circulating blood glucose. Additionally, it can stop glucose production by the liver and reduce its absorption in the body. Sitagliptin inhibits DPP-4 which leads to increased levels of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide(GIP), decreased levels of glucagon, and a stronger insulin response to glucose.

DIRECTIONS FOR USE

• Take JANUMET 50/500MG TABLET, preferably after meals or as advised by your physician
• Swallow the medicine with a glass of water. Do not crush or chew the medicine
• Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition
• Do not stop taking unless your doctor advises you to stop

SIDE EFFECTS OF JANUMET 50/500MG TABLET

Common side effects of JANUMET 50/500MG TABLET:

• hypoglycemia (low blood sugar)
• flatulence, diarrhea, constipation, stomach pain, and loss of appetite
• swelling of the hands and legs (edema)
• metallic taste
• drowsiness, dizziness
• dry mouth

Stop taking and consult your doctor immediately if you experience any of the following side effects:

• serious allergic reaction (such as hives, swelling of the face, lips, tongue, or throat causing difficulty breathing or swallowing)
• severe blistering of the skin (signs of an allergic skin reaction called bullous pemphigoid)
• signs of pancreatitis (severe and persistent pain in the stomach areas that might reach through to your back with or without nausea and vomiting)
• signs of lactic acidosis (cold hands or feet, dizziness or lightheadedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking JANUMET 50/500MG TABLET, inform your doctor if you are taking any of the following medicines, such as:

• Anti-diabetics (Ex. glimepiride, glyburide, gliclazide, teneligliptin, rosiglitazone, pioglitazone)
• iodine contrast medium
• Bronchodilators (Ex. salbutamol or terbutaline)
• corticosteroids Ex. hydrocortisone, prednisolone)
• diuretics (Ex. furosemide, hydrochlorothiazide)
• NSAID’s (Ex. ibuprofen and celecoxib)
• Antihypertensives (Ex. atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, and telmisartan)
• alcohol-containing medicines (such as cough syrups)
• H2 blockers (Ex. cimetidine)
• Anti-viral agents (Ex. dolutegravir)
• Anti-Anginal agents (Ex. ranolazine)
• Antibiotics (Ex. trimethoprim)
• Cardiac glycosides (Ex. digoxin)

Overdosage:

If you or anyone else accidentally took more JANUMET 50/500MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose are feeling cold or uncomfortable, severe nausea or vomiting, stomach pain, unexplained weight loss, muscular cramps, and fast breathing.

SYNOPSIS