INTRODUCTION ABOUT ISTAMET G IR 50/1000/2 TABLET

ISTAMET G IR 50/1000/2 TABLET is used to manage type 2 diabetes mellitus when diet, exercise and the single agent does not result in adequate glycemic control. It is a combination of Glimepiride,  Metformin and Sitagliptin which belongs to a group of medicines called Antidiabetic agents. Glimepiride lowers blood glucose levels by increasing the amount of insulin released by the pancreas. Metformin decreases the amount of glucose you absorb from your food and the amount of glucose made by the liver. Sitagliptin helps control blood sugar levels by increasing substances (incretins) in the body that make the pancreas release more insulin.

Before taking ISTAMET G IR 50/1000/2 TABLET inform your doctor if you have type 1 diabetes mellitus, diabetic ketoacidosis, severe liver or kidney disease, acute heart problems. Inform your doctor if you are pregnant or breastfeeding before taking the medicine. ISTAMET G IR 50/1000/2 TABLET is not suitable for use by children and adolescents under 18 years of age.

Avoid consumption of alcohol during management with ISTAMET G IR 50/1000/2 TABLET as it may increase or decrease the blood sugar lowering action of ISTAMET G IR 50/1000/2 TABLET and increases the risk of lactic acidosis. The most common side effects of taking ISTAMET G IR 50/1000/2 TABLET are taste disturbance, nausea, diarrhea, stomachache, and vomiting. Contact your doctor if any of the above symptoms worsen.

USES OF ISTAMET G IR 50/1000/2 TABLET

• It is used to manage type 2 diabetes mellitus

HOW ISTAMET G IR 50/1000/2 TABLET WORKS

ISTAMET G IR 50/1000/2 TABLET is a combination of Glimepiride, Metformin, and Sitagliptin. Metformin decreases blood glucose levels by decreasing hepatic glucose production, decreasing the intestinal absorption of glucose, and in muscles by increasing insulin sensitivity and improving peripheral glucose uptake and utilization. Glimepiride blocks the ATP-sensitive potassium channel by binding non-specifically to the B sites of both sulfonylurea receptor-1 (SUR1) and sulfonylurea receptor-2A (SUR2A) subunits as well as the A site of SUR1 subunit of the channel to promote insulin secretion from the beta cell. Sitagliptin helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar when there is too much sugar in the blood.

DIRECTIONS FOR USE

Take ISTAMET G IR 50/1000/2 TABLET as advised by your physician. Swallow ISTAMET G IR 50/1000/2 TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking ISTAMET G IR 50/1000/2 TABLET without informing your doctor.

SIDE EFFECTS OF ISTAMET G IR 50/1000/2 TABLET

HOW TO MANAGE SIDE EFFECTS

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

• Imidazoles (Ex. Miconazole, Fluconazole)
• Antibiotics (Ex. Rifampin, vancomycin)
• Diuretics (Ex. Furosemide)
• Calcium-channel blockers (Ex. Nifedipine)
• Potassium-sparing diuretic (Ex. Amiloride, triamterene)
• Cardiac glycosides (Ex. digoxin, morphine, procainamide, quinidine, quinine)
• H2 blockers (Ex. Ranitidine)
• Antibacterial drugs (Ex. Trimethoprim)
• Corticosteroids
• Anti-psychotics (Ex. Phenothiazine)
• Anti-Thyroid agents
• Estrogens, Oral contraceptives
• Anti-convulsants (Ex. Phenytoin)
• Pyridinecarboxylic acids (Ex. Nicotinic acid)

Overdosage:

If you or anyone else take too much of ISTAMET G IR 50/1000/2 TABLET, contact your doctor immediately or go to a nearest hospital straight away. Overdosage symptoms of ISTAMET G IR 50/1000/2 TABLET includes risk of low blood sugar levels, and it may cause lactic acidosis. Symptoms of lactic acidosis include vomiting, bellyache with muscle cramps, general feeling of not being well with severe tiredness, reduced body temperature, low heartbeat, and difficulty in breathing.

SYNOPSIS

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