INTRODUCTION ABOUT INDERAL 10MG TABLET

INDERAL 10MG TABLET is used to manage hypertension (high blood pressure), angina (chest pain) and arrhythmia (irregular heart rhythm).

It can also be used to control abnormal increase in blood pressure and/or heart rate caused due to various underlying conditions such as anxiety, overactive thyroid gland, phaeochromocytoma (tumours of adrenal gland) or Hypertrophic Subaortic Stenosis (thickening of heart muscles).

It contains Propranolol which belongs to the group of medicines called Beta blockers.

It can also be used to manage heart attacks and migraine headaches. It also controls shakiness of the body by blocking abnormal nerve signals between the brain and the muscles.

Before taking INDERAL 10MG TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have any other types of anginas (unstable or Prinzmetal angina) or arrhythmia (such as Wolf-Parkinson-White Syndrome), any breathing problems, or diabetes as a precaution.

INDERAL 10MG TABLET is not recommended for use in patients with severe asthma, hypotension (low blood pressure) or shock. It is also not suitable for use in patients with heart block, history of heart attack or heart failure.

Do not take INDERAL 10MG TABLET without consulting your doctor if you are pregnant or breastfeeding. The most common side effects of taking INDERAL 10MG TABLET are cold fingers and toes, slow heartbeat, tiredness, sleep disturbances and Raynaud’s syndrome (numbness and spasm in the fingers followed by warmth and pain). Consult your doctor if any of these side effect troubles you.

USES OF INDERAL 10MG TABLET

• hypertension (high blood pressure)
• angina pectoris (chest pain)
• arrhythmia (irregular heart rhythm)
• migraine (severe headache on side of the head)
• Reduce tremor (shakiness) and anxiety 
• Signs and symptoms of overactive thyroid gland (such as palpitation, nervousness, tremor, fixed stare, severe myopathy and sweating)
• phaeochromocytoma (signs include high blood pressure and fast heart rate caused due to tumour of adrenal glands)
• Hypertrophic Subaortic Stenosis (signs include thickening of heart muscles causing strain on heart while pumping blood)

Benefits of INDERAL 10MG TABLET in Hypertension:

This medication works by reducing the workload on the heart and relaxing blood vessels, resulting in improved blood flow and lower blood pressure levels.

Benefits of INDERAL 10MG TABLET in Angina pectoris:

It reduces chest pain episodes, improves exercise tolerance by minimizing the heart’s exertion, allowing individuals to perform daily activities with reduced discomfort. It also helps manage stress-induced angina by mitigating the physical effects of stress and anxiety on the heart, providing comprehensive protection for patients with this condition.

Benefits of INDERAL 10MG TABLET in arrhythmia:

It helps stabilize the heart by slowing electrical signals in the heart muscle. This action restores a regular rhythm, preventing episodes of rapid or irregular heartbeats.

Benefits of INDERAL 10MG TABLET in migraine:

It helps in preventing migraines by stabilizing blood vessels, modulating nerve activity and blood flow in the brain and reducing the triggers that cause migraine episodes. Many users report a noticeable decline in the frequency and severity of migraines over time.

Benefits of INDERAL 10MG TABLET in tremor and anxiety:

It works by blocking adrenaline’s effect on the body, which calms the overactive signals causing tremors. It is particularly effective in controlling physical symptoms of anxiety, such as a racing heart, sweating, and trembling. By calming the heart rate, it helps individuals feel more at ease in stressful situations. Blocks the body’s adrenaline response, it allows users to remain calm and confident during high-pressure scenarios.

HOW INDERAL 10MG TABLET WORKS

INDERAL 10MG TABLET is a beta-blocker. It works by blocking the actions of certain chemical messengers (such as adrenaline and noradrenaline) in our body that controls the function of the heart, brain and kidneys and lungs.

In the heart, stopping the actions of these chemical messengers reduces the heart rate and force of contraction. This helps to control abnormal heart rate in patients suffering from arrhythmia.

It can also reduce the risk of abnormal heart signs (such as racing heartbeat, nervousness and high blood pressure) associated with phaeochromocytoma or anxiety.

INDERAL 10MG TABLET can relax the blood vessels supplying the heart and the brain. This action improves blood flow and oxygen supply to the heart and makes the heart to pump blood more efficiently with less pressure. It also helps in managing and managing problems caused due to poor blood circulation such as chest pain (angina), heart attack or migraine.

Additionally, INDERAL 10MG TABLET reduces the production of thyroid hormones (triiodothyronine) in patients suffering from overactive thyroid gland. It also stops the transfer of abnormal nerve signals between the brain and the muscles which helps in reducing tremors.

DIRECTIONS FOR USE

Take INDERAL 10MG TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Dosage and Administration

• Follow Prescribed Dosage- it varies based on the medical condition and individual response.
• Always follow your doctor’s prescription. Do not adjust the dosage without consulting your healthcare provider.
• Common starting doses include:

                              Hypertension: 40mg twice daily.

                              Migraine Prevention: 40mg two to three times daily.

                              Anxiety: 40mg taken as needed (30-60 minutes before a stressful situation).

                              Arrhythmias: 10-40mg three to four times daily.

• It is best taken on an empty stomach or before meals for better absorption.

Missed Dosage instructions for INDERAL 10MG TABLET:

• If you miss a dose of INDERAL 10MG TABLET take it as soon as you remember. If it is almost time for your next dose, skip the missed dose.
• Do not double the dose to make up for the missed one.
• Consistency is essential, especially for chronic conditions like hypertension and arrhythmias. Setting reminders can help ensure timely doses.

Overdosage of INDERAL 10MG TABLET:

• Taking more than the prescribed dose of INDERAL 10MG TABLET can lead to serious complications, including extremely slow heart rate (bradycardia), difficulty breathing, low blood pressure (hypotension), seizures or loss of consciousness.
• What to Do in Case of Overdose: Immediately seek medical attention or contact a poison control center. Symptoms of overdose require urgent intervention, which may include supportive measures like activated charcoal or IV fluids.

SIDE EFFECTS OF INDERAL 10MG TABLET

Like all medicines, INDERAL 10MG TABLET may cause certain side effects, although not everybody gets them.

The most common side effects of taking INDERAL 10MG TABLET are:

• fingers and toes may become cold
• slow heartbeat
• signs of Raynaud’s syndrome (numbness and spasm in the fingers followed by warmth and pain)
• sleep disturbances, nightmares
• fatigue (tiredness)

When to consult your doctor?

• signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth, or throat which can lead to difficulty in breathing or swallowing)
• slow heart rate and low blood pressure causing dizziness, light-headedness, fainting or blurred vision
• worsening of existing condition

HOW TO MANAGE SIDE EFFECTS

WARNING & PRECAUTIONS

SAFETY ADVICE

Expert advice to follow while taking INDERAL 10MG TABLET:

• Take as prescribed and at the same time daily.
• Monitor blood pressure and heart rate regularly.
• Avoid sudden discontinuation of the medication.
• Be mindful of alcohol, smoking, and other medications.
• Protect yourself in cold weather.
• Inform your doctor about any side effects or new medications.
• Use caution during pregnancy and breastfeeding.
• Monitor blood glucose levels if diabetic.
• Visit your healthcare provider regularly for check-ups.

INTERACTIONS

A. Drug - Drug interactions:

1. Calcium Channel Blockers (e.g., Verapamil, Diltiazem)

Both calcium channel blockers and beta-blockers like Inderal reduce heart rate and blood pressure. When taken together, they can cause excessive bradycardia (slow heart rate) and hypotension (low blood pressure).

2. Clonidine (Alpha-2 Agonist)

Clonidine can synergistically lower blood pressure. However, abrupt discontinuation of clonidine while on propranolol can cause a rebound hypertensive crisis.

3.Antiarrhythmic Drugs (e.g., Amiodarone, Sotalol)

Combining antiarrhythmic drugs can increase the risk of heart block and severe bradycardia, particularly in patients with pre-existing heart conditions.

4.Antidepressants (e.g., Fluoxetine, Paroxetine)

Some selective serotonin reuptake inhibitors (SSRIs) may increase the plasma concentration of propranolol, potentially leading to an enhanced beta-blocking effect and increased risk of bradycardia.

5. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) (e.g., Ibuprofen, Naproxen)

NSAIDs may reduce the effectiveness of Inderal in controlling blood pressure by inhibiting the production of prostaglandins, which help regulate kidney function.

6.Insulin and Oral Hypoglycemics

Beta-blockers like propranolol can mask the symptoms of hypoglycemia (low blood sugar), making it harder to recognize low blood sugar levels, especially in diabetics.

7.Monoamine Oxidase Inhibitors (MAOIs) (e.g., Phenelzine, Tranylcypromine)

The combination of MAOIs and Inderal can lead to a hypertensive crisis due to excessive catecholamine release.

8.Ergot Alkaloids (e.g., Ergotamine)

Ergotamine, often used to treat migraines, can cause vasoconstriction, and when combined with propranolol, it may further increase the risk of severe hypertension or poor circulation.

Refer the drug-drug interactions of propranolol, drugs.com

SYNOPSIS

MORE INFORMATION

1. Onset of Action: After taking a 40mg tablet of propranolol by mouth, the drug typically begins to take effect within 30 to 60 minutes. The maximum concentration of propranolol in the blood is usually reached around 1 to 2 hours after oral ingestion. At this point, the therapeutic effects are most pronounced, such as a reduction in heart rate, blood pressure, and anxiety symptoms.
2. Duration of Action: The effects of propranolol can last approximately 3 to 6 hours after a single dose. Propranolol also comes in extended-release formulations (such as Inderal LA), which can provide prolonged action, lasting up to 24 hours.