INTRODUCTION ABOUT INAPURE 5MG TABLET

INAPURE 5MG TABLET contains Ivabradine which belongs to the group of medicines called Hyperpolarization-activated cyclic nucleotide-gated channel blockers. INAPURE 5MG TABLET is used to manage symptomatic stable angina pectoris (chest pain) in adult patients who are intolerant/incapable to take heart medicines (such as beta blockers) and whose heart rate is over/equal to 70 beats per minute.

It is also used to manage chronic heart failure in adult patients whose heart rate is over/equal to 75 beats per minute which are used as a combination therapy with beta-blockers or in adult patients who are contraindicated to use beta blockers.

INAPURE 5MG TABLET is not recommended for use in patients allergic to ivabradine. It is also not recommended for use in patients suffering from very low blood pressure, heart problems (such as unstable angina, cardiogenic shock), severe kidney disease, and/or severe liver disease.

Before taking INAPURE 5MG TABLET, inform your doctor if you have mild to moderate low blood pressure, chronic eye retinal disease, recent stroke (cerebral attack), heart rhythm disorders (such as irregular heartbeat, palpitation, increase in chest pain), and/or moderate liver disease.

INAPURE 5MG TABLET is generally not recommended for use in pregnant and breast-feeding women which is also not recommended for use in children and adolescents (aged below 18 years). The medicine is advised to be used with caution in elderly patients (aged above 65 years) after consulting the doctor.

The most common side effects of taking INAPURE 5MG TABLET are brief moments of increased brightness (due to sudden changes in light intensity), slow heart rate, uncontrolled blood pressure, headache, dizziness, and/or blurred vision. Consult your doctor if any of these symptoms worsen.

USES OF INAPURE 5MG TABLET

• Symptomatic stable angina pectoris (chest pain) in adult patients (with heart rate above/equal to 70 beats/minute)
• Chronic heart failure in adult patients (with heart rate above/equal to 75 beats/minute)

HOW INAPURE 5MG TABLET WORKS

INAPURE 5MG TABLET works by reducing the heart rate which leads to low oxygen requirement of the heart resulting in improved blood supply throughout the body (with each hear beat) thus providing relief from angina pectoris and managing the occurrence of chronic heart failure in affected individuals.

DIRECTIONS FOR USE

Tablet:

Take INAPURE 5MG TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending on your age, body weight and disease condition.

Orally Disintegrating Tablet:

Take INAPURE 5MG TABLET as advised by your physician. Place INAPURE 5MG TABLET inside your mouth and allow it to dissolve completely. Do not swallow or chew the medicine.. Your physician will decide the correct dose and duration for you depending on your age, body weight and disease condition.

SIDE EFFECTS OF INAPURE 5MG TABLET

HOW TO MANAGE SIDE EFFECTS

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes and apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom does not improve.

Dizziness:

Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.

Nausea:

Try to take INAPURE 5MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.

Constipation:

Try to eat high-fibre foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Involve in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor to receive alternate managements for constipation.

Diarrhoea:

Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to manage diarrhoea. Consult your doctor and inform them if the symptom gets worse.

WARNING & PRECAUTIONS

INTERACTIONS

A.Drug - Drug interactions:

Before taking INAPURE 5MG TABLET, inform your doctor if you are taking any of the following medicine:

• medicines used to manage fungal infections (Ex. fluconazole, ketoconazole, itraconazole)
• rifampicin (medicine used to manage tuberculosis)
• barbiturates (medicines used for difficulty sleeping or epilepsy)
• phenytoin (used for epilepsy)
• hypericum perforatum/St John’s Wort (herbal medicines used for depression)
• medicines used to manage heart rhythm disorders (Ex. quinidine, disopyramide, sotalol, ibutilide, amiodarone)
• bepridil (medicine used to manage angina pectoris)
• medicines to manage anxiety, schizophrenia or other psychoses (Ex. pimozide, ziprasidone, sertindole)
• medicines used to manage malaria (Ex. mefloquine,halofantrine)
• intravenous erythromycin (medicine used to manage bacterial infections in different parts of the body)
• pentamidine (medicine used in the management of pneumocystis pneumonia, leishmaniasis, trypanosomiasis)
• cisapride (used for acid reflux)
• diuretics (medicines used to manage oedema, high blood pressure) Ex. furosemide, hydrochlorothiazide, indapamide
• clarithromycin, josamycin, telithromycin,erythromycin (medicines used for bacterial infections)
• nelfinavir, ritonavir (medicines used to manage HIV infections)
• nefazodone (medicine used to manage depression)
• diltiazem, verapamil (medicines used to manage high blood pressure/angina pectoris)

B.Drug -Food interaction:

Avoid drinking grapefruit juice while taking INAPURE 5MG TABLET as it may alter the effect of the medicine.

Overdosage:

If you or anyone else accidentally take too much of INAPURE 5MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are breathlessness and tiredness.

SYNOPSIS

MORE INFORMATION

• Keep INAPURE 5MG TABLET out of the sight and reach of children
• Store at room temperature