INTRODUCTION ABOUT FIBATOR 20MG TABLET

FIBATOR 20MG TABLET is a combination medication used to manage cholesterol levels and reduce the risk of cardiovascular diseases. It reduces the levels of bad cholesterol (VLDL and LDL) and triglycerides in the body by modulating the actions of certain enzymes that are involved in lipid metabolism (such as HMG-CoA reductase and lipoprotein lipase). Additionally, it can also reduce the amount of cholesterol absorbed in the body.

Take the tablet at the same time each day to maintain consistent blood levels of the medication. Avoid drinking large amounts of alcohol while taking this cholesterol medicine. If you are diabetic, work on your blood sugar levels and keep them under control. Before using FIBATOR 20MG TABLET, inform your doctor if you have liver or kidney problems, are pregnant or breastfeeding, are taking other medications that may interact with Atorvastatin or Fenofibrate.

It is also not suitable for use in patients who had recently taken an antibiotic called Fusidic acid to manage bacterial infections. Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with this medicine.

The most common side effects of taking FIBATOR 20MG TABLET are muscle pain or weakness, headache, abdominal discomfort and elevated liver enzymes. Consult your doctor if they bother you. You must also inform your doctor if you experience severe unexplained muscle pain or weakness with fever, weakness or reddish-brown urine after taking FIBATOR 20MG TABLET.

USES OF FIBATOR 20MG TABLET

• Reduces bad cholesterol (LDL) and triglycerides
• Increases good cholesterol (HDL)
• Reduces the risk of cardiovascular complications like heart attacks and strokes

Benefits of FIBATOR 20MG TABLET:

For Hyperlipidemia:

FIBATOR 20MG TABLET reduces low-density lipoprotein (LDL) cholesterol, a primary factor in the development of atherosclerosis and plaque buildup in arteries. Lowering LDL cholesterol helps reduce the risk of heart attacks and strokes. It increases levels of high-density lipoprotein (HDL) cholesterol, which helps remove excess LDL cholesterol from the bloodstream.

Benefits of FIBATOR 20MG TABLET:

To reduce the risk of cardiovascular diseases:

FIBATOR 20MG TABLET helps to reduce plaque buildup, it helps lower the risk of atherosclerosis, a leading cause of heart attacks and strokes. It reduces triglycerides to protect heart health and increases HDL cholesterol, higher HDL levels are associated with a lower risk of heart disease and improved vascular health.

HOW FIBATOR 20MG TABLET WORKS

FIBATOR 20MG TABLET is a lipid-lowering medicine. It reduces the levels of bad cholesterol (VLDL and LDL) and triglycerides in the body by modulating the actions of certain enzymes that are involved in lipid metabolism. Additionally, it can also reduce the amount of cholesterol absorbed in the body. By lowering the blood lipid levels, FIBATOR 20MG TABLET manages fat deposition within the blood vessels and reduces the chances of heart attack, stroke, atherosclerosis or other circulatory problems.

DIRECTIONS FOR USE

Take FIBATOR 20MG TABLET preferably after meals. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Dosage and Administration:

• Take one Tablet daily at the same time every day to maintain consistent blood levels of the medication or as prescribed by your healthcare provider
• Dosage may vary based on individual health conditions such as liver function, age, or other medical factors. Always follow your doctor’s instructions.

Missed dose instructions for FIBATOR 20MG TABLET:

• If you forgot a dose, take as soon as you remember
• If it’s almost time for your next dose, skip the forgotten dose
• Do not take an extra dose to compensate for the missed one, as this may increase the risk of side effects

Overdosage instructions for FIBATOR 20MG TABLET:

• Overdosing may cause symptoms such as severe muscle pain, weakness, nausea, liver damage, or gastrointestinal distress
• In case of overdose, seek immediate medical attention or contact a poison control center.
• Bring the medication packaging or a written record of the dose consumed for reference during emergencies

SIDE EFFECTS OF FIBATOR 20MG TABLET

Like all medicines, FIBATOR 20MG TABLET may cause certain side effects, although not everybody gets them.

Most common side effects of FIBATOR 20MG TABLET are:

• muscle pain or weakness
• headache
• abdominal discomfort
• elevated liver enzymes

When to consult your doctor?

• severe allergic skin reactions (such as skin rash, itching, skin redness with blisters or peeling of the skin, swelling in the mouth, which may be associated with high fever and joint pains)
• unexplained muscle pain or weakness, especially if accompanied by fever, weakness or reddish-brown urine
• severe stomach pain due to inflammation of the pancreas
• signs of blood clots in the body (such as chest pain, shortness of breath, pain, redness and swelling in the legs)

HOW TO MANAGE SIDE EFFECTS

WARNING & PRECAUTIONS

SAFETY ADVICE

Quick Tips:

• Follow Prescribed Dosage: Always take the medicine exactly as prescribed by your doctor. Do not alter the dosage without consulting a healthcare professional.
• Take at the Same Time Daily: Establish a routine by taking the tablet at the same time each day, with or without food, for maximum effectiveness.
• Monitor Liver Function: Regular liver function tests are essential during treatment to ensure safety and avoid potential side effects.
• Stay Hydrated: Drink plenty of water to support kidney function and reduce the risk of muscle-related side effects.
• Avoid Alcohol: Limit or avoid alcohol consumption, as it can increase the risk of liver damage when combined with the medicine.
• Inform About Other Medications: Let your doctor know about all other medications, supplements, or herbal remedies you’re taking to avoid harmful interactions.
• Report Muscle Symptoms: Notify your doctor immediately if you experience unexplained muscle pain, weakness, or tenderness, as these could indicate serious side effects.
• Contraceptive Use: Women should consult their doctor if they are using hormonal contraceptives, as the medication may alter its effectiveness.
• Avoid During Pregnancy and Breastfeeding: Not recommended for use during pregnancy or breastfeeding due to potential risks to the baby.
• Be Cautious with Grapefruit: Avoid grapefruit or grapefruit juice, as it may interfere with the metabolism of atorvastatin in the tablet.
• Monitor Blood Sugar: Diabetic patients should regularly check their blood sugar levels, as it may influence glucose metabolism.
• Exercise and Diet: Combine the medication with a healthy diet and regular exercise to enhance its lipid-lowering effects.
• Missed Dose: If you forgot a dose, take it as soon as you remember, but skip it if it’s almost time for your next dose. Never double the dose to make up for the missed one.

Always consult your healthcare provider for personalized advice to ensure safe and effective use

INTERACTIONS

A. Drug-Drug interactions:  

Before taking FIBATOR 20MG TABLET inform to your doctor, if you are taking any of these medicines:

Anticoagulants (e.g., Warfarin)

• Interaction: Atorvastatin and fenofibrate can enhance Warfarin’s anticoagulant effect by displacing it from plasma proteins or inhibiting its metabolism. This increases the risk of excessive bleeding
• Effect: Prolonged clotting times, increased risk of bruising, nosebleeds, or internal bleeding

Antibiotics (e.g., Erythromycin)

• Interaction: Erythromycin, a macrolide antibiotic, inhibits the cytochrome P450 3A4 (CYP3A4) enzyme, which is responsible for metabolizing atorvastatin. This can lead to increased levels of atorvastatin in the bloodstream, raising the risk of adverse effects.
• Effect: Elevated atorvastatin levels can cause severe muscle-related side effects, including myopathy (muscle pain or weakness) and, in rare cases, rhabdomyolysis (muscle breakdown leading to kidney damage).

Contraceptives (e.g., Ethinylestradiol)

• Interaction: Atorvastatin influence the metabolism of ethinylestradiol by inducing or inhibiting liver enzymes such as cytochrome P450. Fenofibrate’s lipid-modifying action may alter how ethinylestradiol affects cholesterol and triglyceride levels, potentially impacting cardiovascular health.
• Effect: The combination may increase liver enzyme levels, leading to a higher risk of hepatotoxicity. Atorvastatin might reduce the effectiveness of oral contraceptives by influencing their metabolism, potentially increasing the risk of unintended pregnancy.

Antidiabetics (e.g., Rosiglitazone)

• Interaction: Both atorvastatin and rosiglitazone are metabolized by the liver via cytochrome P450 enzymes (CYP3A4 and CYP2C8, respectively). Co-administration may alter drug metabolism, affecting efficacy and side effects. Fenofibrate’s lipid-lowering effects and rosiglitazone’s impact on glucose metabolism may interact, leading to imbalances in lipid and glucose homeostasis.
• Effect: It may elevate liver enzyme levels, increasing the risk of liver damage

B. Drug- Food Interactions:

Avoid drinking grapefruit juice while taking FIBATOR 20MG TABLET as it may increase the risk of side effects.

SYNOPSIS

MORE INFORMATION

Duration of Action: FIBATOR 20MG TABLET provides effective, 24-hour coverage for lipid management due to the sustained actions of both atorvastatin and fenofibrate. Single Daily Dose: Both components of FIBATOR 20MG TABLET work together to provide continuous benefits with just one tablet per day.

Onset of Action: The combined onset of action of FIBATOR 20MG TABLET occurs relatively quickly, with initial effects on lipid levels starting within 2 to 4 days. However, the maximum therapeutic benefit is typically observed after 2 to 4 weeks of consistent use.