INTRODUCTION ABOUT DILNIP TRIO 6.25 TABLET

DILNIP TRIO 6.25 TABLET is a combination of Chlorthalidone, Cilnidipine and Telmisartan which belongs to the group of medicines called Antihypertensive drugs. It is used to manage essential hypertension in adults. High blood pressure that is not caused by any other condition is called essential hypertension. Symptoms of essential hypertension include early morning headaches, nosebleeds, irregular heartbeat, vision changes, buzzing in the ears, fatigue (feeling overtiredness), nausea, vomiting, confusion, anxiety, chest pain and muscle tremors (shakiness).

DILNIP TRIO 6.25 TABLET is not recommended for use in patients with liver, kidney and heart disease. DILNIP TRIO 6.25 TABLET is not recommended in early pregnancy and must not be taken when more than 3 months pregnant, as it may cause serious harm to the baby if used after 3 months of pregnancy. DILNIP TRIO 6.25 TABLET is not suitable for use by breastfeeding women. DILNIP TRIO 6.25 TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your doctor before taking this medicine.

DILNIP TRIO 6.25 TABLET and it should be used with caution in elderly patients. The most common side effects of taking DILNIP TRIO 6.25 TABLET are dizziness, nausea, headache, constipation, fever and chills. Consult your doctor if the above-mentioned symptoms are not improving.

USES OF DILNIP TRIO 6.25 TABLET

• Manage essential hypertension (high blood pressure) in adults
• Lowers the risk of stroke and heart attack

HOW DILNIP TRIO 6.25 TABLET WORKS

DILNIP TRIO 6.25 TABLET effectively reduces the blood pressure where Chlorthalidone acts by enhancing the excretion of sodium (which is necessary for constriction of blood vessels) and water from the body causing blood vessels to relax and Cilnidipine makes the blood vessels relax and thus lowers the blood pressure by blocking the calcium entry in blood vessels which is necessary for the smooth muscle contraction. Telmisartan acts by blocking the effects of Angiotensin II (a substance produced in your body which causes the narrowing of blood vessels).

DIRECTIONS FOR USE

Take DILNIP TRIO 6.25 TABLET as advised by your physician. Swallow this medicine, do not crush or chew the medicine. The correct dosage and duration of medicine to be taken will be prescribed by your doctor depending on your age, body weight and disease condition.

SIDE EFFECTS OF DILNIP TRIO 6.25 TABLET

HOW TO MANAGE SIDE EFFECTS

Vomiting:

Take this medicine with or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Consult your doctor if your symptom does not improve.

Diarrhea:

Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.

Stomach pain:

Try to rest and relax. Try to have smaller and more frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, contact your doctor.

Dizziness:

When you feel dizzy, lie or sit down immediately. if you're experiencing a severe episode of vertigo, lie in a dark and quiet place with your eyes closed. Vehicle driving should be avoided if you experience frequent dizziness without warning. Talk to your doctor if the symptom worsens.

Skin rash:

Try to avoid hot showers because they may cause skin irritation. Avoid frequent contact and rubbing over the affected area. Use sunscreen and protective clothing when outdoors. If this symptom does not get better, speak to a doctor.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

• digoxin (a medicine used to manage heart failure and abnormal heart rhythm)
• cimetidine (a medicine used for stomach ulcers)
• rifampicin (a medicine used to manage tuberculosis)
• itraconazole, miconazole (medicines used to manage fungal infections)
• angiotensin-converting enzyme inhibitors used to manage high blood pressure (Ex. enalapril, lisinopril, ramipril)
• aliskiren (a medicine used to manage high blood pressure)
• medicines containing lithium (used to manage some types of depression)
• medicines that may increase blood potassium levels such as salt substitutes containing potassium, potassium-sparing diuretics (Ex. amiloride, spironolactone)
• non-steroidal anti-inflammatory drugs - medicines used to manage pain and inflammation (Ex. aspirin, ibuprofen)
• heparin (a medicine used to manage blood clots)
• immunosuppressive agents such as ciclosporin or tacrolimus (used to manage organ rejection after transplant)
• antibiotic trimethoprim (a medicine used to manage urinary tract infections)
• diuretics such as furosemide, hydrochlorothiazide (used to manage oedema or high blood pressure)
• corticosteroids such as dexamethasone, hydrocortisone which are involved in stress, immune response
• baclofen (a medicine used for muscle spasms)
• amifostine (a medicine used in cancer chemotherapy)
• barbiturates (medicine that acts as a central nervous system depressant) such as phenobarbital, pentobarbital
• antidepressants such as citalopram, fluoxetine and paroxetine (a medicine used to manage depression)
• narcotics such as morphine and codeine (a medicine used to manage moderate to severe pain)

B. Drug - Food interaction:

Avoid drinking grapefruit juice while taking DILNIP TRIO 6.25 TABLET as it may increase the levels of this medication in the body.

Overdosage:

If you or anyone else accidentally take too much of DILNIP TRIO 6.25 TABLET, consult your doctor immediately or visit the nearby hospital as it may increase the risk of side effects. Signs and symptoms of overdosage include low blood pressure, dizziness, nausea, sleepiness, elevated creatinine levels, sudden kidney failure, electrolyte disturbances associated with cardiac arrhythmias (irregular heartbeat) and muscle stiffness.

SYNOPSIS

MORE INFORMATION

• Keep DILNIP TRIO 6.25 TABLET out of reach from children
• Store at a temperature not exceeding 30°C