INTRODUCTION ABOUT CYRA D CAPSULE

CYRA D CAPSULE is used to manage Gastro-Esophageal Reflux Disease (GERD) among patients who have not responded adequately to rabeprazole alone. It is a combination of Domperidone and Rabeprazole which belongs to the group of medicines called Dopamine Antagonists and Proton pump inhibitors respectively. It can also be used to manage peptic ulcers caused by H. pylori infection or NSAIDs use.

Along management with CYRA D CAPSULE, try to eat less spicy foods and drink plenty of water. Avoid smoking or alcohol consumption as it may aggravate your existing condition. Patients receiving long-term management with the medicine should be kept on regular surveillance to rule out the risk of hypomagnesaemia (decreased magnesium levels in blood) and bone fracture, predominantly in the elderly patients and in patients with other recognized risk factors.

Before taking CYRA D CAPSULE inform your doctor if you have any liver, kidney or heart problems. Your doctor may reduce the dose or suggest an alternative therapy. It is not recommended for use in pregnant or breastfeeding women and in children (aged less than 18 years). It should be used with caution in elderly patients (above 65 years of age). The most common side effects are nausea, vomiting, stomach pain, diarrhea or constipation. Consult your doctor if any of these above side effects worsen.

USES OF CYRA D CAPSULE

It is used to manage:

• peptic ulcer
• Gastro-Esophageal Reflux Disease (GERD)

HOW CYRA D CAPSULE WORKS

CYRA D CAPSULE reduces stomach ulcers and acid reflux, where Rabeprazole acts by inhibiting the secretions of stomach acid and Domperidone acts by increasing bowel movements and facilitating gastric emptying, thus leading to rapid symptom relief and healing of stomach ulcers and esophageal lesions.

DIRECTIONS FOR USE

• Take CYRA D CAPSULE as advised by your physician
• Swallow the medicine with a glass of water. Do not crush or chew the medicine
• Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition

SIDE EFFECTS OF CYRA D CAPSULE

Common side effects of CYRA D CAPSULE:

• nausea, vomiting
• diarrhea, constipation, stomach pain, flatulence
• cough, sore throat, runny nose
• back pain
• headache, dizziness
• dry mouth
• benign polyps in the stomach
• indigestion, belching in the stomach (excess air accumulation in the stomach)
• urinary tract infection

Stop taking CYRA D CAPSULE and contact your doctor immediately if you experience the following side effects:

• severe allergic reaction (sudden wheezing, swelling of lips, face or body, rash, fainting or difficulties swallowing)
• symptoms of liver problems (yellow skin, dark urine and tiredness)
• severe skin reactions such as erythema multiforme, stevens-johnson syndrome or toxic epidermal necrolysis (reddening of skin with blisters or peeling and may be associated with a high fever and joint pains, also severe blisters and bleeding in the lips, eyes, mouth, nose and genitals)
• seizures
• involuntary movements of the face or arms and legs, excessive trembling, excessive muscle stiffness or muscle spasm
• heart rhythm disorders (rapid or irregular heartbeat)

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking the medicine, inform to your doctor if you are taking any of these medicines:

• Prokinetic agent (Ex. Cisapride, dolasetron, prucalopride, diphemanil)
• Cardiac glycosides (Ex. Digoxin, apomorphine, disopyramide, hydroquinidine, quinidine, amiodarone, dofetilide, dronedarone, ibutilide, sotalol, diltiazem or verapamil)
• Ant-viral agents (Ex. Atazanavir, nelfinavir, saquinavir, Telaprevir)
• Antipsychotics (Ex. Haloperidol, pimozide, sertindole)
• Antidepressants (Ex. Escitalopram or citalopram)
• Antibiotics (Ex. Moxifloxacin, erythromycin, levofloxacin, clarithromycin, telithromycin or amoxicillin)
• Antimalarials (Ex. Halofantrine, lumefantrine)
• Antihistamines (Ex. Mizolastine, mequitazine)
• Nonsteroidal antiestrogens (Ex. Toremifene, vandetanib, vincamine, erlotinib, dasatinib, nilotinib)
• Antimetabolites (Ex. Methotrexate)
• Antihypertensives (Ex. Bepridil)
• Opioid narcotics (Ex. Methadone)
• Iron salts
• Immunosuppressants (Ex. Tacrolimus or mycophenolate mofetil)
• Antifungals (Ex. Ketoconazole, itraconazole)
• Anti-infective (Ex. Pentamidine)
• Anticoagulants (Ex. Warfarin)

Overdosage:

If you or anyone else take too much of CYRA D CAPSULE, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms are altered consciousness, agitation, convulsions, disorientation, sleepiness and extrapyramidal reactions (such as rigidity, tremor, drooling).

SYNOPSIS