INTRODUCTION ABOUT CLOPILET A 75 CAPSULE

CLOPILET A 75 CAPSULE is a combination of Aspirin and Clopidogrel which belongs to the group of medicines called Antiplatelets. CLOPILET A 75 CAPSULE is used in the management of early and long-term atherothrombotic events such as myocardial infarction (also known as heart attack), stroke (reduced blood supply to brain leading to brain death), cardiovascular death or refractory ischemia (chest pain due to inadequate blood supply to the heart) in patients having acute coronary syndrome with or without cardiac revascularization (including surgical or PCI, with or without stent insertion).

Acute coronary syndrome is a heart condition caused by plaque rupture or clot formation in the coronary arteries. Symptoms include heart attack, chest pressure or pain while at rest, shortness of breath and sweating.

Along management with CLOPILET A 75 CAPSULE follow a healthy low-fat diet as advised by doctor to achieve better results. Avoid drinking alcohol during management with CLOPILET A 75 CAPSULE, as it could increase the risk of bleeding in the gastrointestinal tract.

Do not stop taking CLOPILET A 75 CAPSULE abruptly without consulting your doctor because premature discontinuation of this medicine may increase the risk of cardiovascular events. CLOPILET A 75 CAPSULE is not recommended for use in patients having severe liver, kidney or lung disease.

CLOPILET A 75 CAPSULE is generally not recommended for use in pregnant or breastfeeding women and in children (below 18 years). Consult your doctor for an alternative therapy.

The most common side effects of taking CLOPILET A 75 CAPSULE are diarrhea, nausea, stomach pain and indigestion. Contact your doctor if any of the symptoms worsen.

USES OF CLOPILET A 75 CAPSULE

• To manage atherothrombotic events (such as myocardial infarction, stroke, cardiovascular death or refractory ischemia) in patients having acute coronary syndrome with or without cardiac revascularization (including surgical or PCI, with or without stent insertion)

HOW CLOPILET A 75 CAPSULE WORKS

CLOPILET A 75 CAPSULE reduces the risk of heart problems, where clopidogrel acts by irreversibly inhibiting platelet aggregation in the coronary arteries and aspirin acts by blocking an enzyme called cyclo-oxygenase 1 which is believed to be responsible for catalyzing the synthesis of platelets, thus leading to the management of fatal cardiac outcomes.

DIRECTIONS FOR USE

Take CLOPILET A 75 CAPSULE as advised by your physician. Swallow CLOPILET A 75 CAPSULE with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF CLOPILET A 75 CAPSULE

HOW TO MANAGE SIDE EFFECTS

Nausea and vomiting:

Try to take CLOPILET A 75 CAPSULE with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom did not improve.

Diarrhea:

Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for managing diarrhea. Consult your doctor if the symptom did not improve.

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.

Flatulence:

Eat smaller and frequent meals. Eat and drink slowly and exercise regularly. Consult your doctor if the symptom did not improve.

Constipation:

Eat fiber rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.

Indigestion:

Eat only when you are hungry. Try to eat smaller portions at a time. Always try to have a nutritious snack that is high in calories and protein, such as dried fruit and nuts. Consult your doctor if the symptom did not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking CLOPILET A 75 CAPSULE inform to your doctor, if you are taking any of these medicines:

• other anticoagulant medicines used to manage blood clots (Ex. warfarin, heparin, coumarin) or dipyridamole
• medicines used to manage stomach ulcers such as antacids (Ex. aluminium hydroxide, magnesium hydroxide) and proton-pump inhibitors (Ex. omeprazole or esomeprazole)
• other non-steroidal anti-inflammatory drugs (Ex. ibuprofen, paracetamol)
• glycoprotein IIb/IIIa inhibitors (used during percutaneous coronary intervention) Ex. abciximab, eptifibatide and tirofiban
• medicines used to manage heart problems or hypertension (Ex. captopril, enalapril, lisinopril)
• selective serotonin reuptake inhibitors (used to manage depression) Ex. fluoxetine, sertraline, paroxetine etc
• methotrexate (used to manage cancer and other auto immune diseases)
• diuretics (used to increase urine output) Ex. furosemide, chlorothiazide
• acetazolamide (used to manage or manage altitude sickness)
• digoxin (used to manage abnormal heart rate)
• lithium (used to manage metal illness)
• corticosteroids (used to manage pain and inflammation) Ex. prednisolone, dexamethasone
• medicines used to manage epilepsy (Ex. phenytoin, valproic acid)
• ciclosporin or tacrolimus (used to manage graft rejection or manage auto-immune disease)
• ticlopidine (an antiplatelet medicine used to manage heart problems)
• medicines used to manage gout (such as probenecid, sulfinpyrazone or benzbromarone)
• fluconazole or voriconazole (used to manage fungal infection)
• medicines used to manage HIV infection (Ex. efavirenz or tenofovir)
• varicella vaccine (used to manage chickenpox or shingles)
• moclobemide (a medicine used to manage depression)
• medicines used to control blood glucose level (Ex. glipizide, gliclazide, glimepiride, repaglinide)
• paclitaxel (used to manage certain forms of cancer)
• nicorandil (used to manage chest pain)
• mifepristone (abortion pill)
• metoclopramide (used to manage vomiting)

Overdosage:

If you or anyone else take too much of CLOPILET A 75 CAPSULE, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of CLOPILET A 75 CAPSULE might include increased bleeding, confusion, disorientation, coma, convulsions, vomiting, tinnitus (ringing in the ears), vertigo (spinning sensation), sweating, warm extremities with bounding pulses, increased respiratory rate, hyperventilation, low blood sugar levels, low potassium and platelets levels in blood, increased body temperature, kidney failure, respiratory alkalosis, metabolic acidosis and pulmonary edema (non-cardiac related).

SYNOPSIS