INTRODUCTION ABOUT AMARYL MV 1MG TABLET

AMARYL MV 1MG TABLET is used in adults to manage type 2 diabetes mellitus when diet, exercise, and single-agent or second-line therapy with two drugs are insufficient to adequately control blood sugar levels. It contains a combination of three medicines namely, Glimepiride, Metformin and Voglibose, which works by making your body absorb circulating blood glucose levels.

Take AMARYL MV 1MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

AMARYL MV 1MG TABLET is not recommended for use in patients allergic to glimepiride, metformin, voglibose, and/or other sulfonylureas or sulphonamides. It is also not recommended for use in patients with acute conditions (such as dehydration or severe infection), severe ketosis (a severe complication of diabetes), severe trauma, lung problems (such as acute or chronic respiratory failure), heart problems (such as acute or chronic cardiac failure or recent myocardial infarction), and/or severe kidney or liver problems. Before taking AMARYL MV 1MG TABLET, inform your doctor if you recently had trauma and/or have febrile infections, fever, uncontrolled diabetes, hypothyroidism (underactive thyroid), chronic intestinal disease, fever, or other kidney or liver problems.

AMARYL MV 1MG TABLET is not recommended for use in pregnant and breastfeeding women since it may cause harm to the developing fetus or nursing child. AMARYL MV 1MG TABLET is also not recommended for use in children and adolescents (aged below 18 years) and is advised to be used with caution in elderly patients (aged 75 years or older) after consulting the doctor.

The most common side effects of AMARYL MV 1MG TABLET are nausea and vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, and/or hypoglycemia (low blood sugar).

USES OF AMARYL MV 1MG TABLET

• Type II diabetes mellitus

HOW AMARYL MV 1MG TABLET WORKS

AMARYL MV 1MG TABLET contains a combination of three medicines namely, glimepiride, metformin, and voglibose. Each of these drugs works in a different way to help lower blood sugar:

1. Glimepiride: It stimulates the pancreas to release more insulin, which helps lower blood sugar by allowing cells to take in glucose.
2. Metformin: It decreases the amount of glucose produced by the liver and improves the sensitivity of muscle cells to insulin, allowing them to use glucose more effectively.
3. Voglibose: It inhibits enzymes in the gut that break down carbohydrates into glucose, slowing down the absorption of sugar from food.

Together, these actions help control blood sugar levels throughout the day by improving insulin secretion, reducing glucose production, and slowing sugar absorption.

DIRECTIONS FOR USE

• Take AMARYL MV 1MG TABLET under medical supervision. It can be taken once or twice daily with meals, depending on your doctor’s advice
• Taking it with food helps reduce stomach upset and ensures proper absorption of the medication.
• The tablet should be swallowed whole with water. Do not crush, chew, or break the tablet as this can affect how the medication is absorbed.
• Since glimepiride stimulates insulin release, make sure to eat meals regularly to avoid hypoglycemia (low blood sugar).
• Do not adjust the dose or stop taking the medication without consulting your healthcare provider.
• Always follow your doctor's specific instructions, and regularly monitor your blood sugar levels as advised.

SIDE EFFECTS OF AMARYL MV 1MG TABLET

Common Side Effects of AMARYL MV 1MG TABLET:

• Nausea, vomiting, diarrhea, abdominal pain, and loss of appetite
• Metallic taste
• Hypoglycaemia (low blood sugar)

Stop taking AMARYL MV 1MG TABLET and contact your doctor immediately if you experience any of the following side effects:

• Severe hypoglycemia (very low blood sugar level)
• Signs of lactic acidosis (lactic acid built up in the bloodstream) such as exhaustion or extreme fatigue, body weakness, diarrhea, and/or headache

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking AMARYL MV 1MG TABLET, inform your doctor if you are taking any of the following medicines:

• Antibacterials (Ex. rifampicin, ciprofloxacin, clarithromycin, sulfacetamide, minocycline, and chloramphenicol)
• Antifungals (Ex. fluconazole, isavuconazole, and miconazole)
• Oral antidiabetics and insulin (medicines used to manage high blood sugar) Ex. glipizide, glyburide diazoxide
• Anticancer (Ex. cyclophosphamide, trofosfamide, vandetanib, crizotinib, olaparib)
• Disopyramide (medicine used to manage an irregular heartbeat)
• Fenyramidol (a medicine used to relax muscles)
• Pentoxifylline (a medicine used to improve blood flow through the arteries)
• Medicine used to manage joint pain (Ex. phenylbutazone, oxyphenbutazone, and probenecid sulfinpyrazone)
• Corticosteroids (Ex. prednisolone, methylprednisolone)
• Diuretics (Ex. Furosemide)
• Laxatives (Ex. Bisacodyl)
• Phenytoin and fenfluramine (medicines used to manage seizures)
• Dolutegravir (a medicine used to manage HIV infection)
• Antidepressants (Ex. phenelzine, selegiline)
• alpha blockers (Ex. doxazosin, prazosin)
• Anticoagulants (Ex. Warfarin)

Overdosage:

If you or anyone else accidentally takes too much of AMARYL MV 1MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are hypoglycemia (low blood sugar), lactic acidosis, pancreatitis (inflammation of the pancreas), abdominal discomfort, and/or diarrhea.

SYNOPSIS