INTRODUCTION ABOUT AMARYL 2MG TABLET

AMARYL 2MG TABLET is used for the management of Type II diabetes mellitus when diet and exercise alone does not result in adequate blood sugar control. It contains Glimepiride which belongs to the group of medicines called Anti-diabetic agents. It stimulates the pancreas to secrete more insulin (a hormone involved in glucose metabolism). It also makes our body more sensitive to insulin which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels.

Along with the therapy, your doctor might ask you to make certain lifestyle changes such as following a healthy diet, regular physical exercise and quitting alcohol consumption. Before taking the medicine, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have any hormonal problems, genetic disorders (such as G6PD deficiency) or if you are malnourished, starved, on an irregular diet. AMARYL 2MG TABLET is not suitable for use in patients with type I diabetes mellitus. Consult your doctor if you are pregnant or planning to become pregnant or breastfeeding.

The most common side effect of taking AMARYL 2MG TABLET is hypoglycemia (low blood sugar levels) which can be identified through symptoms such as increased hunger, sweating, shakiness, weakness or an irregular heartbeat. To avoid this, your doctor will periodically monitor your blood sugar levels and adjust the dose of the medicine accordingly. You can also carry a sugary snack (such as biscuits, glucose drinks or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia. However, consult your doctor if there is no improvement in your condition.

USES OF AMARYL 2MG TABLET

• Used to manage Type II diabetes mellitus

HOW AMARYL 2MG TABLET WORKS

AMARYL 2MG TABLET stimulates the pancreas to secrete more insulin (a hormone involved in glucose metabolism). It also makes our body more sensitive to insulin which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels.

DIRECTIONS FOR USE

• Take AMARYL 2MG TABLET preferably after meals or as advised by your physician
• Swallow the medicine with a glass of water. Do not crush or chew the medicine.
• Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
• Do not stop taking AMARYL 2MG TABLET unless your doctor advice you to stop

SIDE EFFECTS OF AMARYL 2MG TABLET

Common side effects of AMARYL 2MG TABLET:

• hypoglycemia (low blood sugar levels)

Stop taking AMARYL 2MG TABLET and contact your doctor immediately if you experience any of the following side effects:

• severe allergic reaction (inflammation of blood vessels, skin rash, swelling of the face, eyelids, lips, tongue or throat which causes difficulty in breathing or swallowing, drop in blood pressure)
• signs of liver problems (such as fever, yellowing of skin and whites of the eyes, weakness, fatigue, weight loss and loss of appetite)
• increased skin sensitivity to sun
• signs of severe decrease in blood sugar level (such as confusion, headache, excessive sweating, clammy skin, trembling, weakness, double vision, excessive hunger, nausea, vomiting, problems in sleeping, feeling agitated, unable to concentrate, drowsiness, slowed reactions, depression, trouble seeing or speaking, paralysis, numbness, dizziness, hallucinations, difficulty in breathing, slowed or faster heartbeat with chest pain)

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking AMARYL 2MG TABLET, inform your doctor if you are taking any of the following medicines:

• Anti-diabetics agents (Ex. insulin or metformin)
• Non-steroidal anti-inflammatory agents (Ex. aspirin, ibuprofen, phenylbutazone, azopropazone, oxyphenbutazone)
• Antibiotics (Ex. amikacin, nitrofurantoin, sulfamethoxazole, tetracyclines, chloramphenicol, ciprofloxacin, clarithromycin)
• Anti-fungal agents (Ex. fluconazole, miconazole)
• Anti-coagulants (Ex. warfarin)
• Class II AASs (Ex. nandrolone, oxymethalone)
• Hormone replacement (Ex. testosterone)
• Benzamides (Ex. moclobemide, isocarboxazid, phenelzine, tranylcypromine, fluoxetine)
• Anti-lipidemic agents (Ex. fenofibrate, nicotinic acid, colesevelam)
• Angiotensin-converting enzyme (ACE) inhibitors (Ex. enalapril, lisinopril, ramipril)
• Antihypertensives (Ex. atenolol, propranolol, telmisartan, olmesartan, clonidine, guanethidine and reserpine)
• Class 1a anti-arrhythmic agent (Ex. disopyramide)
• Anti-gout agents (Ex. allopurinol, probenecid, sulfinpyrazone)
• Alkylating agents (Ex. cyclophosphamide, ifosfamide, trofosfamide)
• Anticonvulsants (Ex. fenfluramine)
• Hemorrheologic agents (Ex. pentoxifylline)
• Enzyme inhibitor (Ex. tritoqualine)
• Alpha blockers (Ex. prazosin, doxazosin)
• Hormonal replacement therapy (Ex. estradiol)
• Thiazide diuretics (Ex. hydrochlorothiazide)
• Hormones (Ex. Levothyroxine)
• Antipsychotics (Ex. chlorpromazine, prochlorperazine, lithium)
• corticosteroids (Ex. prednisolone, betamethasone)
• Bronchodilators (Ex. salbutamol, terbutaline)
• Alpha- and beta-adrenergic agonists (Ex. adrenaline)
• Laxatives (Ex. lactulose, liquid paraffin)
• Anti-convulsant (Ex. phenytoin)
• Barbiturates (Ex. phenobarbital)
• Carbonic anhydrase inhibitors (Ex. azetazolamide)
• Glycogenolytic agents (Ex. Glucagon, diazoxide)
• H2 blockers (Ex. Cimetidine)

Overdosage:

If you or anyone else accidentally took more of AMARYL 2MG TABLET, you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat and confusion). To manage this, consume any sugary food immediately. If the symptom did not improve or worsens contact your doctor immediately.

SYNOPSIS