INTRODUCTION ABOUT RANOZEX TABLET

RANOZEX TABLET contains Ranolazine which belongs to the group of medicines called Antianginals. It is used to manage chronic angina.

Angina pectoris can be defined as a sudden, sharp and severe chest pain that originates from the apex of the heart and radiates to the left shoulder. It can be characterized by the presence of severe and crushing pain along with a feeling of pressure and suffocation, especially behind the breastbone.

RANOZEX TABLET is not recommended for use in patients with severe kidney disease, moderate to severe liver disease. Contact your doctor before taking.

RANOZEX TABLET should be used with caution in patients with mild to moderate kidney disease, mild liver disease and moderate to severe heart failure, abnormal ECG changes like like QT prolongation or long QT syndrome. Contact your doctor before taking.

RANOZEX TABLET is generally not recommended for use in pregnant women unless considered clearly necessary. Contact your doctor before taking. RANOZEX TABLET is not recommended for use in breastfeeding women as it is not known whether it may pass through the breast milk. Contact your doctor before taking it.

RANOZEX TABLET is not recommended for use in children and adolescents under 18 years of age. Contact your doctor before taking.

RANOZEX TABLET should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking.

Avoid drinking grapefruit juice as it may lead to unwanted effects. The most common side effects of taking RANOZEX TABLET are nausea, vomiting, constipation, dizziness headache and weakness. Contact your doctor if any of the above side effects worsen.

USES OF RANOZEX TABLET

• Used to manage chronic angina

HOW RANOZEX TABLET WORKS

RANOZEX TABLET works by inhibiting the entry of sodium and potassium into the heart cells, thereby managing the calcium influx causing vasodilation and reduces ventricular tension, myocardial oxygen demand. Thus, relieving angina symptoms.

DIRECTIONS FOR USE

Take RANOZEX TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF RANOZEX TABLET

HOW TO MANAGE SIDE EFFECTS

Headache:

Rest and relax. Drink plenty of fluids such as water and electrolytes. Apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom did not improve.

Nausea and Vomiting:

Take the medicine, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food.

Constipation:

Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals. Drink plenty of water and exercise more regularly.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if the symptom did not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before taking RANOZEX TABLET, inform your doctor if you are taking any of the following medicine:

• medicines used to manage bacterial infections (Ex. clarithromycin, telithromycin, erythromycin)
• medicines used to manage fungal infections (Ex. itraconazole, ketoconazole, fluconazole, voriconazole, posaconazole)
• medicines used to manage HIV infection (atazanavir, nelfinavir, ritonavir, indinavir, saquinavir tenofovir disoproxil and efavirenz)
• nefazodone (used for depression)
• medicines used to manage heart problems or heart rhythm disorders (Ex. quinidine, dofetilide, sotalol, metoprolol, diltiazem, verapamil, procainamide, disopyramide)
• medicine used to manage rejection of a transplanted organ (cyclosporine, tacrolimus, sirolimus, everolimus)
• medicines used to manage epilepsy (Ex. phenytoin, carbamazepine or phenobarbital)
• medicines used to manage tuberculosis (Ex. rifampicin, rifampin, rifabutin, rifapentine)
• St. John's Wort (herbal medicine used for depression)
• digoxin (medicines used for heart failure)
• medicines used to manage allergies (Ex. terfenadine, astemizole, mizolastine)
• medicines to manage psychoses (Ex. bupropion, imipramine, doxepin, amitriptyline, paroxetine)
• medicines used to manage cancer (Ex. cyclophosphamide)
• medicines to manage elevated cholesterol levels in the blood (Ex. simvastatin, lovastatin, atorvastatin)
• cimetidine (medicine used for stomach ulcers)
• metformin (medicines used to manage diabetes mellitus)

B. Drug - Food interaction:

Avoid drinking grapefruit juice with this medicine as it may lead to unwanted effects. Consult your doctor for advice.

Overdosage:

If you or anyone else accidentally takes too much of RANOZEX TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are dizziness, nausea and vomiting.

SYNOPSIS

MORE INFORMATION

• Keep RANOZEX TABLET out of the sight and reach of children
• Store RANOZEX TABLET below 25°C